ku80

X-ray repair cross-complementing protein 5

796 amino acids

Involved in non-homologous end joining (NHEJ) DNA double strand break repair.

Belongs to the ku80 family.

90.938 kDa

MTTTIPLKEAVVVILDIGLGMTSKDSDGTTTTTSSIEDALRSVTLLYQQKLIYGKKDQLGLVLIGTKGTKNNLQDDGYQHITVVSDIEEPSIETLKYLENLAPGESKGDVIDSLIVAMDMLIRKTENKKYQKRIFLVTNARDPINTEDLSIVRDQFKKIDVKLNIIGVDFLEEIEENNMDTSNNNKNKSLKEKNEIFLREFAESVDGVLVPVKQALEMMSFFRSQSVMTRTSFRGALEITPELKIPVWGYLKMKQQLLPSLKKISSIAQQQIEQQQQQQQQQNKNKNNEDNEDNEEGKPNITLDVNQEVSYYSITDPDNEILKPDLLKGYKYGKSLIPFSKIDEDQLKYSSSKCLKVVGFTDRKSIPIYYNMGNTEVFVSQPGDKQSEEALSSFIHALVETDQVMVVRYVKTMNGSPYLGYMIPHVKSDYVCLYYNHLPLADDIRQYQFPPISPKNPLTRKSNIPNAEQLEATQQLIDSMDLMKSEFDEDGDPIQMLKPRFTYNPLLQHFYQCLHHRSLHPNTQIPKLDPIIAEYINPDQIIMNKSKQSIKNFADKFPLTKTTVFSKTPAISGGNTNGTTSNTNNTMIGGVKYHWKDGMLIGEEINLDSYVTDDGSEAKKRKVNDFSEFSLDKLVSGYVTEVGTINPVQNFKDMLNRRDMDLVDKAITLMKERILQLVNDSLRDQYYQKAFECIKELRVGCIRESEAEQFNGFLKDMRSLFQSKKRDDFWQYITADVTSILGEKSINLITQDECDSSEVTQEELDQFLDKKVKQFNPPPITNVNTDSVDDLFDQIE

KU80

ATP-dependent DNA helicase II subunit 2

736 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku80 family.

81.825 kDa

MADKEATVYIVDLGESMADCHNGRDESDLDFGMRYVWDKISTTVAASRKTWTLGVVGLNTEETNNAQDSEGLEGYEHISVLQDIGPMTMTQLRELRSSIQTSHTYGGDAISGIVVALAMIELFTKKLKYNRRIILVTNGESPIDDESSEDVANRLNYSNIELIVIGVDFDDADYGFKEEDKSKGKARNEKTLRKLVEQCNNGVFGTMQQAVEELAIPRIKPVRPFKAYDGALTLGDPEKYKSALSIHVERYFKTKRAPAPPASTVVVNSEPGGASQSETLNEDTEMGDAEFSGVKHMRTYRVNDPDAPGGKRDVEFEDLAKGYQYGRTVVPFSESDFSITKLETKKSFTILGFIPFSSYNPFLNLGETGIVVAQKHNEEAELGLSALIHALHELESYAVARYVQKDGAQPQLVLLKPNPAIEDDFECLYDVPLPFAEDLRSYQFPPLDKVLTVTGNIIKEHRLLPSEDLKQAMSDFVDAMDLSGFDVDEDGKPTEYAPIDETYNPTIHRMNQAIRARAVDPDAPIKPPAEILLRFSKPPEKLIEKAKPEIEALIDAAEIKKVPAKAQGRGSRKEPVKPLSGLDIDSLLGESKRTTISLDNAVPEFKQILATAADDATIESAAKQMGQIVRKLIQDSFADLFYARAAENLRVMREELISLEVPGLYNKFLTGLKKSILSGELDGDRREMWFKHIVGGHLSLITQDESEVSEVTAEEAKALCAWSRPNITYRYFRDTA

KU80

ATP-dependent DNA helicase II subunit 2

731 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku80 family.

82.008 kDa

MAEKEATVYIVDVGHSMGKCRGGRTISDLDWMMLYVWDRITTTVSTGRKTATVGVVGLRTDGSSNPLWEKDEEESYAHLSVFQEIGQMLMPDIRKLRDLVKPSNTNQGDAISSIILAIDMIVRYCKRLKYKRKIVLVTDGRSTMDSDGIDSIVSKIKEEGIELVILGVDFDDPDYGFKEEDKDPFKTKNESVLKILADDADGAYGTLAQAVEEMTTPRIKVVRGIPSFRGDLRLGDPSQYSTGLTIQVERYYRTYVARPPAASAFALSIAPPKGQSTAESSVTLQNGDSTVETANASNNLSGVRNARSYQVIDENAPGGKKEVERDDLAKGYEYGRTAVHISESDEVITKLDTTAALEFIGFIQSENYERYMNMSTSNVIIAQKINDKAILALSSMIHALFELEYYAIGRLVTKDGKPPLMVLLAPLIETDFECLLEVQLPFAEDTRSYRFPPLDKIVTVSGKVVKEHRNLPSDDLLETMGKYVEDMDLSEFDENGDPFQSLALEDCYSPLVHRIDQAIRWRAVHPTKPLPPVPKVLEKLSHWPEELVKKSHDSLRDLISISAVKKVPPKAKGRKRRREADKPLSGLNVDDLLRGEKRLKISPENPIPEFKQTLANTEDISAISDAVKQMSAIIEDQIRQSLGDINYDRAIEGIGTMREELIAYEEPGLYNDFIRGLKEKLLDDKLGGDRREMWWLIRKSRLGLIDQKALDISDITEEQAREFLSSRPTTV

KU80

ATP-dependent DNA helicase II subunit 2

726 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku80 family.

81.612 kDa

MASKEATVYVVDLHESMGREMARGHDSKEVTDLNWGLQYIYSEISNKILSGRKTDVVGLVGVHTDTTQNMFEEESGFEHIDIITPIQQFNLDTLLEAKKQLVPNSDNKGDLISGIVVAVQMIKLYTKALKYIRNIVVLTNGQGNMNLGDSGGIIKQLNENRIILKVMGVDFDDEEVDYFEEDKPEHKRENELKLKEFVDRCEDSVFATYKEARDSLDIPKVKAVNPVRAFQGNLVLSDPEQQPPQRVMSIGVEVFPCTRRATAMTASSYAMSKIEPATISTPSQNNLQAVKWDRQYYVNDESGIGGKKELDRDTLENGYRYGSEIVYITKEEEEAIMFPTSASLQVIGFVNKKSVPPYMLMGHTDYIIGQRGNNRDAVAISAFARALFETDNFGLARYVNKDGKDPQIVVLMPYIRAELEGLVFCQLPFAEDERKFILPSLTSLETRSGNKTVTTHSRLLPTKEMLDAMDDYVDAMDLSKLKGEDDEPWLTMEECFNPSIHHIRNVVKECAVSQDYGKIPEPLPILTRFSQPAEELTEEAKPQLELLKHLFDIKEQFREAKKRKTEVTVGQTGLDLDALLEGELEVKLESSQTLSSNVKSEPGRQTASQSSQNSQQLSLDPENICPDFIRTLNKIDTKATSDEEFRSGATNLYKQTITLLEEKLESSKGNDAYNEIIGVLQTMREQADEMEIPDVFTAAKGQFVSKLERGDLGGQKNVLVAQINSI

ku80

ATP-dependent DNA helicase II subunit 2

725 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku80 family.

81.747 kDa

MAEKEATVYIVDVGKSMGEKRNGRSMTDLEWAMQYVWDCITATVATGRKTATIGVIGLKTDETSNELDDDPHFKHISVFTEIQQFLMPDIRRLGALVKPSETDKGDAISAIILAIQMIVTYCKKLKYKRKIVLVTNGQGWMSNEDLDQITKKIKEDNIDLVVLGTDFDDPEYGFKEEGKDPRKAENEALLRGLVEDCNGAFGTLEQAVSEMDIPRAKRVRTVATFKGFLQLGNPEEYDTALRIPVERYYRTYVAKPPSASSFVLRSDVGAEGEQGESSQLPKSPPEGGALTSVRNLRTYEVPDENAPGGKFDVEREELAKGYEYGRTAVHISETDENITTLETYAALELVGFIQTDKYDRYMHMSTTNIIIGQRGNDKASLALSSFIHALFELECYAVARLVVKENKPPVMVLLAPSIEPDYECLLEVQLPFAEDVRTYRFPPLDKVITVSGKVVTEHRNLPNKDLLDAMSEYVDSMELVDTDETGNPVEGLPIDDSFSPVLHRIDSAIRYRAIHPDDPVLPPSKNLTKLSQPPQDLVEKSKAYLQKLMEAADVKKVPPKVKGRKRIRESEKPLSGLDVDALLHQEKRARISPTNAIPEFKQTLTQAETIETIKDAVKQMTSIIEDQIKNSLGDANYDRVIEEMGVMREELISFEEPALYNDFLRQLKDKLLKEELGGDRRELWWLLRRSQLGLINQRESDQSDVTEEQAKEVSLRCHLSSRGIY

ku80

ATP-dependent DNA helicase II subunit 2

725 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.

Belongs to the ku80 family.

81.742 kDa

MADKEATVYIVDVGRSMGECRNGRSVTDLEWAMQYVWDRITGTVATGRKTAMMGVIGLRTDETSNELEDDVHFSHIAVLSNLKQFLMPDIRKLEDELKPSKTDKGDAISAIILAIQMIITHCKKLKYRRKIVLVTNGQGRMSDEDLGEIVKKVKEDNIELVVMGIDFDDPEYGYKEEDKDPHKAENETLLRTLVEDCDGVYGTFEQAVAELDIPRVKSVRSVASFKGYLQLGNPEEYDSALRIPVERYYRTYPAKPPTASSFVLRSEPEAGQEEAESSEAAAATQKGSQSGDAGLTTVRTMRTYQVEDKSAPGGKIDIERDELAKGYEYGRTAVHISETDENITILDTFAGLELMGFIQTDQYQRYMHMSNTNIIIAQRANDKAALALSSFIHALFELECYAVARLVVKENKPPVIVLLAPSIEPEYECLLEVQLPFAEDVRTYRFPPLDKVITVSGKVVTQHRNLPSDDLLDVMGKYVNSMELVDADEDGDPVETFPIDDSYSPVLHRIDAAIRARAIHPDQPIPPPSERLTKFSHPREDLIEKSQKHLEKLIEIADVKKVPPKAKGRKRTRETEKPLSGLDVDALLHHEKRVKISPNNAIPEFKQTLAQAENIEAIKDATKQMMVIVEDQIKHSLGNANYDRVIEALGTMRDELVSYEEPASYNDFLGQLKDKLLQEKLGGDRQELWWLVRRNKLGLVTQRESDQSRVTDTEAKEVSLTKMKE

ku80

ATP-dependent DNA helicase II subunit 2

725 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku80 family.

81.784 kDa

MADKEATVYIVDVGRSMGECRNGRSVTDLEWAMQYVWDRITGTVATGRKTATMGVIGLRTDETSNELEDDVHFSHIAVLSNIKQFLMPDIRKLEDELKPSKTDKGDAISAIILAIQMIITHCKKLKYRRKIALVTNGQGRMSDEDLGEIVKKVKEDNIELVVMGIDFDDPEYGYKEEDKDPRKAENETLLRTLVEDCDGVYGTFEQAVAELDIPRVKSVRSVASFKGYLQLGNPEDYDSALRIPVERYYRTYPAKPPTASSFVLRSEPEAGQEEAESSEAAAATQKGSQSGDIGLTTVRTMRTYQVEDKSAPGGKIDIERDDLAKGYEYGRTAVHISETDENITILDTFAGLELMGFIQTDRYQRYMHMSNTNIIIAQRANDKAALALSSFIHALFELECYAVARLVVKENKPPVIVLLAPSIEPDYECLLEVQLPFAEDVRTYRFPPLDKVITVSGKVVTQHRNLPNDDLLDVMGKYVNSMELVDADEDGDPVETFPIDDSYSPVLHRIDAAIRARAIHPDQPIPPPSERLTKFSHPREDLIERSQKYLEKLIEIADVKKVPPKAKGRKRTRETEKPLSGLDVDALLHHEKRAKISPNNAIPEFKQTLAQAENIEAIKDATKQMMVIVEDQIKHSLGNANYDRVIEALGTMRDELVSYEEPASYNDFLGQLKDKLLQEKLGGDRQELWWLVRRNKLGLVTQRESDQSRVTDTEAKEVSLTKMKE

ku80

ATP-dependent DNA helicase II subunit 2

725 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku80 family.

81.561 kDa

MADKEATVYIVDVGKSMGERRNGRDLTDLEWAMKYVWDCITNTVATGRKTAMLGVIGLKTDGTDNELGDESHFSHISVLSEIKQFLMSDIRELGERIKPSSVDKGDAISALILAIQMIITHCKKLKWKRKIVLITNGLGRMNSENLDDIVSKVKEDNIELIILDLTGRRGPDFDDAEYGIKEEDKDPHKASNETLLRTITERCDGVFGTLEQAVEETEIPRVKPVRPVASFKGFLQLGNPEEYDTAVRIPVERYPRTMVAKPPTASQFVLRSDLAAGQEGPVSSTAVPETQPEDGSNLTNVRNLRTYQVSDESAPGGKIDVERDDLAKGYEYGRTAVHISETDENITRLETTAAMELVGFIQSERYDRYMHLSNTHIIIANRANDKASLALSSFIHALFELESYAVARLVTKENKPPTLVLLAPSIEPDYECLLEVQLPFAEDVRTYRFPPLDHVVTVSGKVVTQHRNLPNDDLLDAMDKYVDSMELKGTDEDGDLVNTPFPIDDSFSPVLHRVNAAIRSRAIHPNDPIPPPARILTQFSQPPEHLLKNAERHLKRLIEVADVKKVPPKAKGRKRAREPEKPLSGLDVDSLLHQEKRVRISPNNAIPEFKQTLAQAENIETMKDAVKQMRSILEDQIRHSLGDANYDRVTEGLGVVREELIAYEEPGLYNDLIRKLKEALLKEKLGGDQRELWWLLKRSKLGLIEQRESELSEVTEEEAKKFMSA

KU80

ATP-dependent DNA helicase II subunit 2

715 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku80 family.

79.398 kDa

MAAIRLISIGLWSMFGIRLPTQVATGRKSALMSVIGCRTDETDLGGVMEEAEGYENLRVFSELKQFLLGDIRTLQDQLRPSKTNDGDLLSALALAVQMIDGATQGKGGKPLKYDRRIIIVTDGRGSIDTDDLEQIAAKIRDPEAPVDLVLLGVDFDDPDNGFKEEDKSSQKAKNEVSLKGFVEDCNGVFGTLAEAIDQLQIPRLKETRPVPSFKGQLTLGDPGHYDATLTIDVERYPCTMLAKPPTASSFATRTDFGAGSAAGPSDESSHTMTGEEQPMTDLSAVRNQRVYQVDNEEEPGMKKNVEMDELERGYEYGRTAVHISESDMNVVKLETTPMLSLIGFVKAEAFERYLPLSRSNFLVPQRGNQAAQLSLSSFIHALYEADCYAVARLVTKELKPPVIVLLVPRIEVEWEALVDVELPFEEDMRRYKFPPLDRKLTISGKVITEHKDLPTDELTDAMSKYVDAMDLSTFGRDEDGNPAEYAKPEDTFSPIVHRIGHIIRWRATHPDPSLPMPPPSDILTKYANPPADLLDASTSQFEALKKAARVSKVPPKVKGRGKRNRAERDKPISGLDIDALLGNPNRVKIDPSNLVPSFKNALAASDDLETIKEAAQSMSTEIRSLIRSSVGDSGYGRALEALRVMRDELTELEEPEIWNEFIRGLKSDLLEGKLNGNRKDMWWKIRGNRYGLVDRKRSFVSDVTEEEASAFYNVA

KU80

ATP-dependent DNA helicase 2 subunit KU80

688 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase (By similarity).

Belongs to the ku80 family.

77.443 kDa

MARNKEALVLLLDVGPSMHGVLQEVENICSTLVHKKLVYNRSDEIGVVLFGTKETSNELAKELGGYKHVVVARDIKVVDEETTNALQNLPRGTSPGDFLDAIVVGLDMLIRKFGNIKGKQRMCLVTDAQHPLRDPPQGTKKDQVDTIADQMKRHEIKMDCIIFRESGVRHNAVMDENDQLLYHFRERSVTKVVHVDSPTSLLGALRTRNVLPVTVFRGDLEVSSSFKIKVWVYKKTSEEKFPTLKKYSDKAPASDKFASHEVKVDYEYKSVLEPDTVVPPDQRIKGYLYGPQVVPISSAEWEAVKFKPEKGVKLLGFTDRSSISRHYFMKDVFSFVPEPGNTKAVAAVSALARAMSEMNKVAILRCVWRQGQGNVALGVLTPNISSAKNVLDSFYFNILPFAEDIREFQFRSFSSLPSSSQPTKEQQEAADNLVKMLDLAPPGREEILKPDFTPNPMLERFYRYLDLKSKQPDANVPPLDKCLKKITEPDPDVIDYQAPLIKKLGNVFELKENPKKKKARTQDRLTYTGADDQAKLLEEPSAEKVGVSEALYPPKKKAGEIGDHNPVQDFEAMLTQRSSSTWVQTAIEEMQKYITALIQDSCDRDNHQKALECLVALRKACIIEQEPNEYNGFVTKLCQKFRPAGDKIFLQLLSSKKASLISKEEAPDSDVTEEMARNFCLKPEPSSQ

KU80

ATP-dependent DNA helicase 2 subunit KU80

680 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Binds to and recombines double-stranded T-DNA molecules.

Belongs to the ku80 family.

76.688 kDa

MARNREGLVLVLDVGPAMRSVLPDVEKACSMLLQKKLIYNKYDEVGIVVFGTEETGNELAREIGGYENVTVLRNIRVVDELAAEHVKQLPRGTVAGDFLDALIVGMDMLIKMYGNAHKGKKRMCLITNAACPTKDPFEGTKDDQVSTIAMKMAAEGIKMESIVMRSNLSGDAHERVIEENDHLLTLFSSNAIAKTVNVDSPLSLLGSLKTRRVAPVTLFRGDLEINPTMKIKVWVYKKVAEERLPTLKMYSDKAPPTDKFAKHEVKVDYDYKVTAESTEVIAPEERIKGFRYGPQVIPISPDQIETLKFKTDKGMKLLGFTEASNILRHYYMKDVNIVVPDPSKEKSVLAVSAIAREMKETNKVAIVRCVWRNGQGNVVVGVLTPNVSERDDTPDSFYFNVLPFAEDVREFPFPSFNKLPSSWKPDEQQQAVADNLVKMLDLAPSAEEEVLKPDLTPNPVLQRFYEYLELKSKSTDATLPPMDGTFKRLMEQDPELSSNNKSIMDTFRGSFEVKENPKLKKASKRLLRDKPSGSDDEDNRMITYDAKENKIDIVGDANPIQDFEAMISRRDKTDWTEKAITQMKNLIMKLVENCTDEGDKALECVLALRKGCVLEQEPKQFNEFLNHLFKLCQERNLSHLLEHFMSKKITLIPKSEAADSDIVDENAGDFIVKQESMLES