ku2

Non-homologous end joining protein Ku 2

306 amino acids

With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

Belongs to the prokaryotic Ku family.

35.112 kDa

MINSPPIGYLPGMRTMWRGAISFGLVNIGVRLYAATADHDYQFHQVHRQDHGRIHHKRVCEECGREIDYDDIVKGYETSDGELVVLDSQDLRKLPIRTDRAIDLLECVPAEQVDPTYFQKTYYLEPEKSARRPYVLLREALRRTDLLAVVKITMRQRETLATIRPAGDVLVLHTMLWPDEIRRPDFDFLTDDAGDTEVSKQEIDMATSLVENMTEDFDPTEFTDDYQRALAELIDAKTKGTKPPRKRPEPADEGEVVDLMGALERSVDQARTSRTSRRKTTASASRRRSSSNREKTGSRDKTRKRA

ku2

Non-homologous end joining protein Ku 2

256 amino acids

With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

Belongs to the prokaryotic Ku family.

29.117 kDa

MAGGTIWKGYIHFADTDVAVKLHAAVKAERIQFHLLHKRDHVKLHQQMICAYEKIPVPTEAQTKGFEVEEGKYIIVDPDELEQTAPESSRMIEVHEFVKTGQIDPIFLDRVYYLEPDLHSEGYSELVGALQEMGAEGICTWTMRNRSYLGALQASGKILRLNTLRYADEVISVKSLELQESPVSEKELKIGSDLINQLTTPFQPQKFENEHEKKLQKLIEKKARGEKIALLRPRLLKPTASDKLLQALEESLKKVA