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kdm7a

Gene
KDM7A
Protein
Lysine-specific demethylase 7A
Organism
Homo sapiens
Length
941 amino acids
Function
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Similarity
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Mass
106.557 kDa
Sequence
MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPIVCPVSRSSNEATSPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDILSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLYTADSENEEDKRRTKKAKMKIEESSGVEGVEHEESQKPLNGFFTRVKSELRSRSSGYSDISESEDSGPECTALKSIFTTEESESSGDEKKQEITSNFKEESNVMRNFLQKSQKPSRSEIPIKRECPTSTSTEEEAIQGMLSMAGLHYSTCLQRQIQSTDCSGERNSLQDPSSCHGSNHEVRQLYRYDKPVECGYHVKTEDPDLRTSSWIKQFDTSRFHPQDLSRSQKCIRKEGSSEISQRVQSRNYVDSSGSSLQNGKYMQNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

Gene
Kdm7a
Protein
Lysine-specific demethylase 7A
Organism
Mus musculus
Length
940 amino acids
Function
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity).
Similarity
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Mass
106.075 kDa
Sequence
MAGAAAAVAAGAAAGAAAAAGSVSAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDVCKDWFHGSCVGVEEHHAVDIDLYHCPDCAALHGSSLMKKRRNWHRHDYTEVDDGSKPVQAGTRAFVKELRSRVFPSADEIIVKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPAFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPDRPKVLNVISLEFSDTKMSELVEVPDIARKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTNENLALYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKSLLETLKELKEDGFQPQSYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPSVCPVSRPSNEASPPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDLLSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQLFADRSLYTADSENEEDKKPTQNANMKTEQSSGREEAESQGSPKPLNRIFTSVRSELRSRPSEYSDGSDSEDSGPDCTALKINFATEDSESSGDEKKHEITSHFKEESDIVRNLLQKSQKPSRQEIPVKRECPTSTSTEEEAIQGMLSMAGLHYSSCLQRQIQSTDCSGEKNSLQDPSSCHGSNPEFRQLYRCNKPVEFGYHAKTEDQDLMTSSWNKQFDRTSRFNAQDLSRSQKHIKKESSSEINQKAQSRHCVDSNSSSIQNGKYTLNPSLVSCQISNGSLSPERPIGETSFSMPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

Gene
kdm7a
Protein
Lysine-specific demethylase 7A
Organism
Xenopus tropicalis
Length
922 amino acids
Function
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).
Similarity
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Mass
105.557 kDa
Sequence
MAGAAPVYCVCRQPYDVSRFMIECDICKDWFHSSCVKVEEHQAADIDLYHCPNCEVLHGPSQLKKRRNWHRHDYTEPDDGTKPVQAGTRTFIQQLQARSFPSADDLLLKMNGSQLTQRYLEKQGFNLPIMVPRLDDLGLRLPPPTFSVMDVERYVGGEKIIDVIDVARQADSKMKLKNFVKYFMNPDRPKVLNVISLEFSDTKMADLVKVPDISKKLSWVENYWPDDSFFTKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKVFYLIKPSDENLALYESWSSSVTQSEEFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELKEDGFHPPNYLKHGVKALISALKSWMKKESVAEHAFEIPDNIRPGHLIKELSKVIRSVEEEGNRPVKSQGIHGHCPVSRSSHEKSSHHSGRKARRLRDHSTKTPTNLDILEHHTREVLKRLEMSPWEEDAGTYKLNMRFNKPLLPSSTEPDQKVRDNGIRLLLSNGRIIRDERQPFTDRSLYTADSEDEDDRARSRKAKDIKQEKPCSTSGMEDKAETQKPLNMFFESVKSELRNGSSEYSDISDSEGSEDNCTNQKHFSEESESSGDDDDEEEEEEEERQEPIRNLKEEHSGRRLPCDPNFPWPDHDSPQKRECPTSTSMEQEAVQGMLSMASLHYPSALPTPAKSTDCNIRGGYPQLHIRVSQGNGKEHLDSHSHKAANSDHHVKDEGEFSALDWIRQPDASCRLSPQDSCQVPQSLRREFAHEEYEKAPEDKHYLEIEHWDSAEYQPEKYDPESSMSSGECHLSDGSLSPTRIYGDTAAAVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

Gene
kdm7a
Protein
Lysine-specific demethylase 7A
Organism
Danio rerio
Length
875 amino acids
Function
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).
Similarity
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Mass
98.827 kDa
Sequence
MAAAPLYCVCRQPYDVNRFMIECDICKDWFHGSCVQVVEHHAADIDVYHCPNCEPIHGPYMMKKHNNWHRHDYTEPNDGTRPVQAGTAVFVKELQARSFASGDILVQMQGNQVTKRFLEKEGFNYPIVVHDLDGLGLKLPPPSFSVSDVEHYVGANKVIDVIDVAKQADSKMKLGEFVKYYYQPERPKVLNVISLEFSDTRMSNLVVVPDIAQKMSWVENYWPDDSFFPKPFVQKYCLMGMKNSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTKANLALYEAWSSSPNQSEVFFGEKVDKCYKCVVKQGTTILLPTGWIHAVLTSQDSMAFGGNFLHNLNIDMQLRCYEMERRLKTPDLFKFPYFEAICWYVAKNLLETLKELRENKCEAQGFLVNGVKALISSLKMWLRRELTQPNSEVPDNIRPGHLIKALSKEIRHLEDDSNKAVKTQGSAECSLSRSTLEKGDQAQQAARRLQDHHHHRRRHHHHHHHHHHHHHHHHSRKLPSNLDVLELHTLEVLKRLEVGQLKEDSAFSSKVNGKFKKVCPVPAAAVEASHDNALRLVMCNGKIIRERMPITNVAATVNAVEMYHKHRIKLERIPMCPEEKVKKEKCEDEFGVQCTIKKPVSQGESVQTELRTESPHLASSDSDSKAGDSAEKCSLESESSDGEDGGSQRDSGTFVEHLNSHRHSHHKQALKRERPTSPNTDCAIQGMLSMAGLLCPQASGGAADILQQRWWASQGNGSSTSSSSDMWDSSEPCSAPRSPDAEDGSLGEEYSYRESSLSPPLHPSKRHAPNPTPVSNQATKGKRPKKGQATAKQRLGKILKMSRHKGLFLMKPMVFLIPQQGGTPLDPQFLLQSSSICVFPPPLIVSG