Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).

Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

922 amino acids

MAGAAPVYCVCRQPYDVSRFMIECDICKDWFHSSCVKVEEHQAADIDLYHCPNCEVLHGPSQLKKRRNWHRHDYTEPDDGTKPVQAGTRTFIQQLQARSFPSADDLLLKMNGSQLTQRYLEKQGFNLPIMVPRLDDLGLRLPPPTFSVMDVERYVGGEKIIDVIDVARQADSKMKLKNFVKYFMNPDRPKVLNVISLEFSDTKMADLVKVPDISKKLSWVENYWPDDSFFTKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKVFYLIKPSDENLALYESWSSSVTQSEEFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELKEDGFHPPNYLKHGVKALISALKSWMKKESVAEHAFEIPDNIRPGHLIKELSKVIRSVEEEGNRPVKSQGIHGHCPVSRSSHEKSSHHSGRKARRLRDHSTKTPTNLDILEHHTREVLKRLEMSPWEEDAGTYKLNMRFNKPLLPSSTEPDQKVRDNGIRLLLSNGRIIRDERQPFTDRSLYTADSEDEDDRARSRKAKDIKQEKPCSTSGMEDKAETQKPLNMFFESVKSELRNGSSEYSDISDSEGSEDNCTNQKHFSEESESSGDDDDEEEEEEEERQEPIRNLKEEHSGRRLPCDPNFPWPDHDSPQKRECPTSTSMEQEAVQGMLSMASLHYPSALPTPAKSTDCNIRGGYPQLHIRVSQGNGKEHLDSHSHKAANSDHHVKDEGEFSALDWIRQPDASCRLSPQDSCQVPQSLRREFAHEEYEKAPEDKHYLEIEHWDSAEYQPEKYDPESSMSSGECHLSDGSLSPTRIYGDTAAAVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

105.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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