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kbtbd8

Gene
kbtbd8
Protein
Kelch repeat and BTB domain-containing protein 8
Organism
Xenopus tropicalis
Length
606 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity).
Similarity
Belongs to the KBTBD8 family.
Mass
69.51 kDa
Sequence
MAQTPSSTASTEVAKYVQTQNGIPPSNPVSSAMDPYHACSILQQLKAMYDEGKLTDIVVQVDHGKHFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRLVGIEAESMQLVLNYAYTSRVQLTEANVQALFTAASIFQIPSLQDQCAQYMISRLEPQNCIGVFSFADHYGHQELKEKAQDYIRKKFLYVTKEQEFLHLRKDQLISILNSDDLDVEKEEHVYDSIISWYEHEQETREMHLPEIFAKCIRMPLMEETFVEQIPPIFAQAMPINRVQKGKISANCCTRRLGMTASEMIICFEAANKHSGKKQTVPCLDTLTGKVYKLCKPPGDLREVGILVTPDNELYIAGGYRPSNNDVCIDHKAESDFWLYDHSSNRWLPKAPLLRARIGCKLVHCCGKLYAIGGRVYEGDGRNPLKSVECYDTRDNCWTAVSLMPVAMEFHSAVEYKDKIYILQGEVFLCYDPPRDYWCYLTPMTAPRVQGMAAVYKDSIYYVAGIRGNHRVLTVEAYDVEQNRWTRKKDLPCEQSSNPYIKLVVFKSKLHLFVRATQVSVEEFVFRTSRKNSLYQYDEIADSWKKVYETPERLWDLGRHFECAVAKLYPQCLQKVL

Gene
kbtbd8
Protein
Kelch repeat and BTB domain-containing protein 8
Organism
Danio rerio
Length
601 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (By similarity). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity).
Similarity
Belongs to the KBTBD8 family.
Mass
68.657 kDa
Sequence
MAASGDVGKLLQVQNGTPASTSYNGVDALHACNILQQLKALYDEAQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESSQREVRIVGVESESMHLVLDYAYTSRVTLTESNVQALFTAASIFQIPALQDQCAQFMISRLDPQNCIGVFMFADAYGHQELRERSQDYIRKKFLCVMGEQEFLHLTKDQLVSILNSDDLNVEKEEHVYESIVHWLEYDCSRREADLPEVFAKCIRLPLLEEAFLSRIPPAFALALSRDSSDKSRLNGTNGCSQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIAAGKVYKLCKPPNDLREVGILISSENDIFIAGGYRPSNSEVCIDHRAESDFWQYEHAGNRWLPRSPMLRARIGCRLVHCCGKLYALGGRVYEGDGRNALKSVECYDARDNCWTAVSPMPVAMEFHSTIEYKDRIYVLQGEYFFCFDPRKDYWGHLPSMNIPRTQGLAALHKNCIYYIAGICRNHQRTFTVEVYDIEQNTWCRKRDLPFDQATSPYIKVLLLQGRLHLFVRATQVMVEEHVFRTSRKNSLYQYDDEADHWTKVYETPDRLWDLGRHFECVVAKLYPQCLQKVL

Gene
KBTBD8
Protein
Kelch repeat and BTB domain-containing protein 8
Organism
Homo sapiens
Length
601 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Similarity
Belongs to the KBTBD8 family.
Mass
68.823 kDa
Sequence
MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL

Gene
Kbtbd8
Protein
Kelch repeat and BTB domain-containing protein 8
Organism
Mus musculus
Length
599 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Similarity
Belongs to the KBTBD8 family.
Mass
68.66 kDa
Sequence
MAASADLSKSSPTPNGIPSSDTANDTMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMDLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQSEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIVKSCGEPSNTSGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRVFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHIFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL

Gene
Kbtbd8
Protein
Kelch repeat and BTB domain-containing protein 8
Organism
Rattus norvegicus
Length
575 amino acids
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Similarity
Belongs to the KBTBD8 family.
Mass
66.322 kDa
Sequence
MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMGLVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDAFIEKIPPRFAQAIVKSCGEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRVFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHIFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL