jmjc-1

Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66

776 amino acids

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).

Belongs to the ROX family. NO66 subfamily.

88.985 kDa

MGKKNKSNGGGNTNNTPTKTPSKPPVKFNDKWASIENGEAKSASVSHYKEPSKEPKFVHPAKLAKEKKIFDGLDIPERVLAHGKVVEQNGGKKRRHREISPKMEAKKPKVESKSKDGVAAKKAHKHFTVSSEVVQSTYFFEEPDNGNEVTLVSNGKETTIEKTVILDEEVEDEEIDEEEFEDEEEVEDEEGMDEDETEIDESEMIVDPKDIERCIEFEDVDDEDEMEDEEEFEDEEEVEDEEVDDEEEEEVADEERGEEQEDEQEEEEEVSDEESVVSEMDADSDDEGFIAGKDREAHVISKDKAARTFAAKPVDFDAFPFNDQDSVVTASRAFGFMVSPCDVQTFFDKFYQSNVLVVHRKTPAYYGNLFSTTRFSELLEKHYLEYNMNINIAQYKDGIRTTLNGKGRVYPQIVKQHLHNLCSVQLVNPQTFDDRIWYLCEILQEQFGCFVGANTYLTPAGSSGFAPHWDEIDAFLLQVEGRKYWRVWAPESAEEELPLESSGNFTEDDMKGKEPVFEGWIEQGDMIYIPRGYTHQARTDKKVHSLHVTVSTGRQWSFANLMEKVIPEAVGALTEERHKLRRGLPIGLFDMGGVVDLDYSQEEHFTEKFKIVVDRHMSRLRNLVADHLLDSSVDSMTKEFMKQALPPILTDKEKKRSVIGLSTNLLGDDLIDFCANTKVKFIRKHTQRLLMESEDSCFISHRMNNSRLFEGRPETLVDFPSTGIDTYRVLWNAYPEWRTLDEIFSCRETKSNTRKEKLAAIQILFQMGVLLVKNPK

jmjc-1

Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66

748 amino acids

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Mediates response to multiple stress stimuli, including heat shock and osmotic, oxidative, and ethanol stress.

Belongs to the ROX family. NO66 subfamily.

86.026 kDa

MGKKKNSNKSAAAAPAVKHNDRWSSIELGEAKSAAVSHYKEPSKEPKFVHPAKLEKVKRIHDGLNIDRVLSHGPVPKQNGGTKRKHVEVTTQKLENKKPKVEVKKEDEKSKNKKMKNQNKHTALVQNETSTRSTYFVEEPDNENKVTLISNGREIAFKKTEVVESDDEQMIGLDSDEELEDEDETDIDEDEMMIDPKDIERYINFESVEDEEDMEDEEIEDEEFEDEEFEDEEEEADEQEEEEEDVSDEESVVSEMDADSDDEGFIAGKDREAHVISKDKFTRNAPAVDFDKFPFTDEDSVVTSSRAFGFMISPCDVQTFFDKFYQSNVLVVRRKQPTYFGNLFSTARLGELLEKNHLEYGRNINIAQYKNGVRTTLNGQGRAYPQIVKQHLHNMCSVQLVNPQTYDDRIWYLCEVIQEQFGCFVGANTYLTPAGSSGFAPHWDEIDAFLLQVEGRKYWRVWAPESAEEELPLESSDNFTEDDMKGREPVFEGWIEKGDMIYIPRGYIHQARTDSKVHSLHVTVSTGRQWSFANLMEKVVPEAIGVLTDTRHKLRRGLPTGLFDMGGVIDLDYSQEDHFVEKFKMVVDRHMSMLRNLVADQLLESSVDSLAKEFMKQALPPRLTEQEKKLSVLGSSTNLLGDDLVDFTARTKVRLIRRHTQRLLMESEDACFISHRINNSRLFEGRPEQIVEYPISGIDAYRVLSNSYPEWRTLYEIFSLRETKTKSRKENLAAIQLLFQIGVLLVKN