Function
Cytokine which binds to interferon gamma receptor 1 (ifngr1) (PubMed:19577303, PubMed:20507977). Has activating effects on primary macrophages (PubMed:20507977). Induces nitric oxide production and phagocytic responses in macrophages (PubMed:20507977). Primes monocytes for production of reactive oxygen intermediates (ROI), although the effect is short-lived (PubMed:20507977). Also has inhibitory effects on monocyte priming by ifng1 (interferon gamma 1) and tnfb (TNF-alpha 2) (PubMed:20507977). Stimulates phosphorylation of the JAK/STAT signal transducer stat1, but fails to induce stat1 nuclear localization (PubMed:20507977). Promotes increased expression of a number of genes important for macrophage activity, including the interferon regulatory factors irf2 and irf9 (PubMed:20507977).