Protein
Guanine nucleotide-binding protein subunit beta
Organism
Dictyostelium discoideum
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development.
Similarity
Belongs to the WD repeat G protein beta family.
Sequence
MSSDISEKIQQARRDAESMKEQIRANRDVMNDTTLKTFTRDLPGLPKMEGKIKVRRNLKGHLAKIYAMHWAEDNVHLVSASQDGKLLVWDGLTTNKVHAIPLRSSWVMTCAYSPTANFVACGGLDNICSIYNLRSREQPIRVCRELNSHTGYLSCCRFLNDRQIVTSSGDMTCILWDVENGTKITEFSDHNGDVMSVSVSPDKNYFISGACDATAKLWDLRSGKCVQTFTGHEADINAVQYFPNGLSFGTGSDDASCRLFDIRADRELMQYTHDNILCGITSVGFSFSGRFLFAGYDDFTCNVWDTLKGERVLSLTGHGNRVSCLGVPTDGMALCTGSWDSLLKIWA