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gap-1

Gene
gap-1
Protein
Ras GTPase-activating protein gap-1
Organism
Caenorhabditis elegans
Length
629 amino acids
Function
GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras.
Mass
71.316 kDa
Sequence
MVLSCRVVDCGGLKLKENQTLLLLVSTIHNSSEVGKLSIDAEEKRSKEWLEMPCAEGMLSLKLTLWQDLLKGINSVFHGQVRVDVDENWKSGPAKWFYLRSKANEDGEGGEDGGDIGDATVKVTYQIDHILRMQVYKPLLDLLFLAGDVQPLTASLVAVIEALPKVELGPVSRSLVELMAQSDRIRPVLSSLYVNSILKCQDENTLFRGQSLSGKMLFEILTTYGKMYLITTLKPVVDKIYKERKNCEVDPARVAVGASLEKNRNNLLVYFQMLFERVTTSSTNCPHLIKQLLYDLRNVVGTHSSRSGVQRLAVSSFVIMRFFAAAILNPKAFEIRKDQPDLRVSRTLLLLSKLLQRLSNCSVSEGPLSSKEIWLNGVFETVTSEQHKSVMASFLDNISLVGDRSEPQKCTVFKFGNLQQVDRSRLAWKKVLHYKKRYVQLTNTHLIWQKDVQCAPKGTVPLSDIKFVNVDNKNIITIVCETMQLQFEAPGGVEATDWLNAIERQRNRAAHEIAETPGEHFFVDAERHVDKIHTLLYKYRETMIEWRDQLQSNVELDEKTAPELLKASYVVEEERQSHKDSLIATLCSTIDVTDAIQLAHTEYEKENKVSRRIDAIITAKKRQKSFSVK