Function
Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the 'non-neural' versus 'neural' cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site.
Sequence
MNPVQQPAQHRSPASLLHLPHPKRAQEAPDMGLYCDNFMFSQQNLHPSQRAPNFSIGGEFTPPANPYLWLGGPGMNNAPNYSPAPAPYIPSAFSAPQRHFMANSAAFGGADLGWMSAASQEELLKMVRPPYSYSALIAMAIQNASDKRLTLSQIYQYVAENFPFYKKSKAGWQNSIRHNLSLNDCFKKMPRDENDPGKGNYWTLDSNCEKMFDNGNFRRKRKPKSESNNAKIAKRDEDHLNPKGKESPPMITPSSSPEVLSPTGHSKSPSPPTVTYTPCLTNFIGSMTAVDSATMNRQSPLGLLNELSQRNITGLSSFISGSAVDQSSEHQDNSLFYNRSPYYTNQKQPHFLQQLHPQQPPLYQGRY