Protein
5'-3' exoribonuclease 2
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).
Similarity
Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
Sequence
MGIPAAFRWLSTKYPKIISPVIEDQPITMPDGTVIPVDATKPNPNGEEFDNLYLDMNGIVHPCSHPEDRPAPKDEEEMMVEVFKYTDRVVNMVRPRKLLMIAVDGVAPRAKMNQQRSRRFRAAREAMEKEEDKQKFVELLKKQNGKPQEEEPVEVVVKKAFDSNSITPGTPFMDILAASLRYWCSYKLNTDPAWANIKVIISDATVPGEGEHKIMEFVRSQRGSPNHDPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFAQDSRPRLCKICGQKGHDAMNCKGEAKEKNGEFDEKDAVVPLKPFIWLHVSILREYLAIELDVPGLPFQFNLERAIDDWVFMCFFVGNDFLPHLPALEIRENGIDTLTAIWKDNLPVMGGYLTKDGHADLERVQYIMAGLAKQEDAIFRRRKETEDRREAGFKRRKLADEARQRRAQGSRQIRQAAENSGPPAGFSFHKINEFPGKAPQPSITHDMVVNRQAVDQANVANKSAASVLKDQIKSMMAQGTSTPENGAESTETPAETAAAAPATEEQAAPPAALGKRKAELIEDAVAGPEASSTEVTEISESDAEPTDSVRLWEEGYADRYYEQKFKVDRKDIDFRHKVGRAYAEGLAWVLEYYFQGCPSWEWFYPYHYAPFAADFVDLGKMEIKFEKGRISRPFEQLMSVLPAASRHAIPEVFHSLMLEETSEIRHFYPDDFEIDLNGKKMAWQGVALLPFIDMPRLLAAMETKSHLLSPEDHLRNAPGKDYLLLSDSHPTLYDHITSQFYSKKQGTTKFELDPTKSAGLSGLVEKIDGYVPHGSLVYPLSRNSMPDVDYDRSLMVHYFFPDCSHTHKSMLLRGVQMPTPALTRSDIDILKGKASRSGRSYGGVPLSNKNYSGRNEPINYGPGGGQQGGRGRGGYQGGGGRGGGRGGYGGNGGGYQANGGGYYNGGNNGGGGGGYGGQPRDSYGPPPGWQPPPPPGLAGFGVGPPPPPPGAAYGGAPGGAGYGGYGSSRGGYQDNRYALPPPPPQAYQAQGQQYGQGGSRGGYQGQGNQYRGPPRQDRGYDNRGGYRGGGYRGGGDNRGYR