Protein
Transcription factor coe2-B
Function
May play a pivotal role in the transcriptional cascade that specifies primary neurons in embryos. Stabilizes the higher neural potential of selected progenitor cells that express neurog2/X-ngnr-1 by maintaining Delta-Notch signaling. Thus ensures the transition between neural competence and irreversible commitment to a neural fate. Also promotes neuronal differentiation by activating neurod1 expression, directly or indirectly.
Similarity
Belongs to the COE family.
Sequence
MFGVQETFGTALRDKALGVGMDPVRSWVRNVGVVDAKVAAQSGVAVSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPIEIERTSFVDFVENEKEFSTEKTNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPISYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTDPSLEYATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERMAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNHNQIPALSSSPVHSGMMGINSYGGQLGVSISESQANNQGYIRNTSSISPRGYSSSSTPQQSNYSTPSNSMNGYSNVPMSNLGVPGSPGFINGSPTTSPYGIMPSSPPVGSSGSSSILPFSSSVFPSIKQKSAFAPVIRPQGSPSPACSSSNSNGFRAMTGLVVPPM