csx1

Gene

csx1

Protein

RNA-binding post-transcriptional regulator csx1

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

632 amino acids

Function

Regulates global gene expression after oxidative stress. Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover.

Mass

67.87 kDa

Sequence

MSIDCLYRRSSLFDTSFVPLHSSIPATSKMSASNSDVNAPISPVVDEGKSELVSPTLERLVAPFNCSPSSTPLQDVAGVGSKMSDTLWMGDLEPWMDATFIQQLWASLNEPVNVKVMRSKASSSETLISYCFVQFSSSAAAERALMKYNNTMIPGAHCTFKLNWATGGGIQHNNFVSRDPEFSIFVGDLLPTTEDSDLFMTFRSIYPSCTSAKIIVDPVTGLSRKYGFVRFSSEKEQQHALMHMQGYLCQGRPLRISVASPKSRASIAADSALGIVPTSTSNRQPNQDLCSMDPLNTTVFVGGLASNLSEKDLQVCFQPFGRILNIKIPFGKGCGFVQYSEKSAAEKAINTMQGALVGTSHIRLAWGHNTLPVSALSQSQSQVSDEGFDRTLSANQIFGMNQSVIGANSGSSNSSGSSLKSAPVSPRTAAAQSLLPNSVVSSINGMNSVNFSTISPPPLSRSASISPTLSGSGSGLTPLSSHFPSAATGLVGGQVYPQSSVLQSSKINGSAKVQPSVKLPEWLQPFSGNNHNSFATQDLLTRVSSLKLVDDEQPASLNGSAFQARASRPWNLGRERQSSLIDLRHELEQNENGLEKSGFGLNLRGRLPPRSYSTFNCTGQYLQPSLRLSRDS

Protein

RNA-binding post-transcriptional regulator csx1: csx1

Gene

csx1

Protein

CRISPR system endoribonuclease Csx1

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

Length

465 amino acids

Function

Activated by cyclic oligoadenylate (cOA) to endonucleolytically degrade linear RNA; when cOA levels decrease the RNase activity of Csx1 is abrogated.

Similarity

Belongs to the CRISPR-associated Csx1 family.

Mass

54.5 kDa

Sequence

MQKILIAPWGNFSSWKKVIYSFNGVEKESKSSLSAIYDKINPDKVYILVLDTLSNLESENYGDIVKEVKEKTENFIKENLNIDNYEVIVCPGVGTFYNKDFEKYFKFYGNLTDYYSFALYELSKRLDGDLEVHLDLTHGLNYMPVLTYRVIKDLLEILAIKNKVRLVVYNSDPYVGREKEILNIHTVEDVIIKPSYDIKGMTLDFLDATKFVDKKEIGKIKKEINMNPKIKELRIMKQNINAFIASIVYALPLVYSTFFVKKDKIEIYLNELIGAFISNIKINPEDKILKRYLYFGEGFNSLVKAYFASKISEIPQLIKDELSLEEIDELKNTLFKENPNSQYIKNEISSLYNIINTKYKEEELSEILGNWTPIYKIRRENIDKFKIRNFLAHAGFEKSVTEIYISVENKNGKIELSEKTSLRYNKNYIEEKNGIKRFIFKYKDKNGKVEEINILEKIEEILLNK

Protein

CRISPR system endoribonuclease Csx1: csx1

Gene

csx1

Protein

CRISPR system endoribonuclease Csx1

Organism

Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Length

377 amino acids

Function

Activated by cyclic tetraadenylate (cA4) to endonucleolytically degrade linear RNA; when cA4 levels decrease the RNase activity of Csx1 is abrogated.

Similarity

Belongs to the CRISPR-associated Csx1 family.

Mass

42.929 kDa

Sequence

MASIVFSTIGNPKGYQKVTYEIDGEKFESNVSVLALRDLLKVDKTVVILGISVADVYNCKYADYRSCKECIIQNSKNDLGISESYVVAPNVYQKFKGKPDHYFTYIYYHSLRILEKEGINEVFIDTTHGINYMGVLAKEAIQLAVSAYAAKSEKEVKVSLYNSDPVGKDVSDTVKLHEIEAIKISPLSGLKYVTYQILNKDKNFFNKIFSDSVNAIPRFATALDNGLFIYLSEKDSSLHLKRLEDDLSKDPLLTPSENEINVVYKDMKYALSHALFYVISRFSGNVDLDTLRHYAETYADKVTRAIIENEVDKIEKYQMGSERKLLGEYMKVEGKGFDKRILYAHGGLPYAGTYVYKEKDKVYVTYGDKIDEIERQI

Protein

CRISPR system endoribonuclease Csx1: csx1