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cnbZ

Gene
cnbZ
Protein
2-amino-5-chloromuconate deaminase
Organism
Comamonas testosteroni
Length
251 amino acids
Function
Involved in the biodegradation of xenobiotic compounds, such as nitrobenzene and 4-chloronitrobenzene (4-CNB) (PubMed:16517619). CnbZ preferentially catalyzes the deamination of 2-amino-5-chloromuconate (2A5CM) to yield 2-hydroxy-5-chloromuconate (2H5CM). Also able to catalyze the deamination of 2-aminomuconate to yield 2-hydroxymuconate, which spontaneously converts into its keto form, 2-oxalocrotonate.
Mass
27.648 kDa
Sequence
MPDAVVFSPGGYRYIPAVFQYSAGIAAEPGFEIERVRFHRPVPLAEAFVAVESHLRAIGRPTTSFAQCELRSPDPFNDQGFIDFNTEYVKTLERWGIYKDRVNPVARTNVCPMYDKPTTPSMFAFSYTVPTTSAAKRPSFQLAGGGDARGGSAPYKDRIVAFGDTSPEGLREKVVFVIEEMESRLKTLGLGWADAVSTQLYTVQNIGHLVGPELARRGCGAGGLVWNYTRPPVIGLEYEMDVRGAVRETVL