Protein
ATP-dependent Clp protease proteolytic subunit
Organism
Caulobacter vibrioides (strain NA1000 / CB15N)
Function
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity (By similarity). Plays a major role in the degradation of misfolded proteins (By similarity). Required for degradation of response regulator CtrA, thus contributing to the G1-to-S transition (PubMed:9755166). Required to degrade DNA replication inhibitor toxin SocB, this function is probably the reason why the protease is essential in this organism (PubMed:24239291).
Similarity
Belongs to the peptidase S14 family.
Sequence
MYDPVSTAMNLVPMVVEQTSRGERAFDIFSRLLKERIIFLTGPVEDGMASLICAQLLFLESENPKKEIAMYINSPGGVVTAGLAIYDTMQYIKSPVSTVCMGMAASMGSLLLAAGAAGQRISLPNARIMVHQPSGGFRGQASDIERHAEDIIKTKRRLNEIYVKHCGRTYEEVERTLDRDHFMSADEAKAWGLVDHVYDSRDAAEAGAE