ced-1

Cell death abnormality protein 1

1134 amino acids

Involved in programmed cell death/apoptosis. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (By similarity).

121.087 kDa

MRLLLLVGVLLAATWQVGYTRAPTFPDKSKSAADAINEPKGEHVCTVKTIVDDYELRKVIHQVVYNDTEQCLNPLTGFQCVVEKRGQKASYQRQLVQKEKYIKQCCEGYYQTKDNQCQPDCNPPCKKGKCVEPGKCECDPGFGGKICSSSCSIGTWGLGCSKKCDCENGANCDPELGDCICPSGFQGKRCEEECPIDKWGPNCVKSCPCQNGGKCNHEGKCVCTDGWGGEYCLNKCEEGKFGADCKFECTCQNGATCDNTNGKCLCKSGFHGALCEKPCSEGFFGAGCTQKCQCLNNQDCDSETGECKCIGWTGKQCDIGCARGRFGLQCKQKCTCPGLEFQDSNASCDAKTGECQCESGYKGANCDERKCSADTYGADCSKQCSCVMSNTVMCAPNTGFCRCKPGFYGDNCELACSKDSYGPNCEKQAMCDWTHASEADPANGKCVCKSGRSGANCSQPCPIDFYGPNCALQCECNGRGIGCHGFDGKCNCAPGYTGHRCEHHCPALTFGANCEKRCQCPAGVGCNPITGECECPAGRQGLKCDISCPEGSYGPECKLHCKCVNGKCDPETGECSCEPGFGGADCSTSCPKGKYGDACELSCDCSDSYCSRQTGKCICPLGKKGTLCDQPCEANTYGPQCQLTTTPSQCASTDPRNGVCLTCPPGSSGHQCEQNCPQGTYGTDCASKCACADGGHGCDPTTGECICEPGYHGATCSEKCPDGKFGYACAQNCPKCAAGSSCDHISGQCVCPAGLEGATCTRPCGVGFWGNGCRQVCRCTSEFKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATASCNRVTGVCICHPGFTGEFCHALCPESTFGLRCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEALNGGRAKSSGATWLLILFIIGLCGVLGLAALFYRNKYQKEKDPDMPTVSFHKSPNAEDNREFQNPLYNRQSVFPDSGAFSGSSEGGVGAAPDGLLTLEEEDLEDKKIHGGGASRNMRNHDYASLDEVAGGEGGPATSSSSGVQNRRGQNSGDVRRPLLNSEDVDDDDEDEDFEEIPHENRNSTQKLSLERNSKFSEKNFKKKFLSENPYAHIPSPDPNIQNSTNSRRAQENLYT

ced-1

Cell death abnormality protein 1

1111 amino acids

Involved in programmed cell death, also called apoptosis, in both somatic and germ cells (PubMed:11163239, PubMed:6857247, PubMed:1936965, PubMed:15744306, PubMed:16740477, PubMed:18351800, PubMed:26598553, PubMed:27650246). Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse (PubMed:15744306). Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation (PubMed:16740477, PubMed:18351800). Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (PubMed:18606143).

118.804 kDa

MRLILLVLLATWQVVVDTRAPTFPDKLTQQLQQQGTTEPQGDHVCTVKTIVDDYELKKVIHTVVYNDTEQCLNPLTGFQCTVEKRGQKASYQRQLVKKEKYVKQCCDGYYQTKDHFCLPDCNPPCKKGKCIEPGKCECDPGYGGKYCASSCSVGTWGLGCSKSCDCENGANCDPELGTCICTSGFQGERCEKPCPDNKWGPNCVKSCPCQNGGKCNKEGKCVCSDGWGGEFCLNKCEEGKFGAECKFECNCQNGATCDNTNGKCICKSGYHGALCENECSVGFFGSGCTQKCDCLNNQNCDSSSGECKCIGWTGKHCDIGCSRGRFGLQCKQNCTCPGLEFSDSNASCDAKTGQCQCESGYKGPKCDERKCDAEQYGADCSKTCTCVRENTLMCAPNTGFCRCKPGFYGDNCELACSKDSYGPNCEKQAMCDWNHASECNPETGSCVCKPGRTGKNCSEPCPLDFYGPNCAHQCQCNQRGVGCDGADGKCQCDRGWTGHRCEHHCPADTFGANCEKRCKCPKGIGCDPITGECTCPAGLQGANCDIGCPEGSYGPGCKLHCKCVNGKCDKETGECTCQPGFFGSDCSTTCSKGKYGESCELSCPCSDASCSKQTGKCLCPLGTKGVSCDQKCDPNTFGFLCQETVTPSPCASTDPKNGVCLSCPPGSSGIHCEHNCPAGSYGDGCQQVCSCADGHGCDPTTGECICEPGYHGKTCSEKCPDGKYGYGCALDCPKCASGSTCDHINGLCICPAGLEGALCTRPCSAGFWGNGCRQVCRCTSEYKQCNAQTGECSCPAGFQGDRCDKPCEDGYYGPDCIKKCKCQGTATSSCNRVSGACHCHPGFTGEFCHALCPESTFGLKCSKECPKDGCGDGYECDAAIGCCHVDQMSCGKAKQEFEALNGAGRSTGLTWFFVLLIVALCGGLGLIALFYRNKYQKEKDPDMPTVSFHKAPNNDEGREFQNPLYSRQSVFPDSDAFSSENNGNHQGGPPNGLLTLEEEELENKKIHGRSAAGRGNNDYASLDEVAGEGSSSSASASASRRGLNSSEQSRRPLLEEHDEEEFDEPHENSISPAHAVTTSNHNENPYADISSPDPVTQNSANKKRAQDNLYT