ccl2

Cytochrome c-type biogenesis protein Ccl2

149 amino acids

Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.

Belongs to the CcmH/CycL/Ccl2/NrfF family.

16.738 kDa

MLKRLLLLLVLATPVHAVQPDEVLSDPGLEARARQISQVLRCPVCQGENIDESNAGVSRDLRLAVRERLVAGDSDAQVIDYIKDRFGEYVLFEPERRGANLILYWIGPAVLVVALGGIFLWLRGRRREEEPVPVLSAEEEARLKDLLKD

CCL2

C-C motif chemokine 2

120 amino acids

Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).

Belongs to the intercrine beta (chemokine CC) family.

13.741 kDa

MQRSSVLLCLLVIEATFCSLLMAQPDGVNTPTCCYTFNKQIPLKRVKGYERITSSRCPQEAVIFRTLKNKEVCADPTQKWVQDYIAKLDQRTQQKQNSTAPQTSKPLNIRFTTQDPKNRS

CCL2

C-C motif chemokine 2

101 amino acids

Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). May play a significant role in monocyte trafficking into the reperfused myocardium (PubMed:9024159).

Belongs to the intercrine beta (chemokine CC) family.

11.121 kDa

MKVSAALLCLLLIAAALTTQVLTQPDAIISPVTCCYTLTNKKISIQRLASYKRVTSSKCPKEAVIFKTVLNKEICADPKQKWVQDSMAHLDKKSQTQTAKP

CCL2

C-C motif chemokine 2

99 amino acids

Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).

Belongs to the intercrine beta (chemokine CC) family.

11.114 kDa

MKVSAALLCLLLTVAAFSTEVLAQPDAINSQVACCYTFNSKKISMQRLMNYRRVTSSKCPKEAVIFKTILGKELCADPKQKWVQDSINYLNKKNQTPKP