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bzaA

Gene
bzaA
Protein
5-hydroxybenzimidazole synthase BzaA
Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Length
432 amino acids
Function
Together with BzaB, probably catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by M.thermoacetica (PubMed:26246619). Requires BzaB for catalytic activity, as BzaA alone displays no activity (By similarity).
Similarity
Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.
Mass
46.398 kDa
Sequence
MNLIESARAGLITPEMEQVAVQEGVTPEFVRQGVADGTIVILRNARRQNVTPVGVGKGLRTKVSASVGLYGETGGIDVEVAKIKAAVEAGTDAIMDLSVSGDIEAMLAETLAVSPKPVGTLPLYQAMAEAGRKYGSSVNMRDEDLFDVIERHAAAGVDFLALHCGTTMNIVERARNEGRIDPLVSYGGSHLIGWMLANRRENPLYEHFDRVLAIARKYDVTISFADGMRPGCLADSLDGPQVEELVVLGELVRRAREAGVQVMVKGPGHVPLQQLKATVVLEKSLCHGAPYFVFGPLVTDIAIGYDHINAAIGGALSAWAGAEFLCYVTAAEHVGIPDIDQVREGVIAARIAAHAADLANGLTCAREWDRELSRARKELDWKRQIALAIDPERAGRLREERSDAAAAGCAMCGKYCAMEIVSRYLGTARHTC

Gene
bzaA
Protein
5-hydroxybenzimidazole synthase BzaA
Organism
Eubacterium limosum
Length
427 amino acids
Function
Together with BzaB, catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of dimethylbenzimidazole (DMB), the lower axial ligand of vitamin B12 (cobalamin). Requires BzaB for catalytic activity, as BzaA alone displays no activity.
Similarity
Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.
Mass
46.636 kDa
Sequence
MTLLEKAKCGEITAEMQYVAEKEGVRPEFICEGVANGDIVILYSSRENIHPVAVGKGLLTKVSASVGMYEEADTVDGEMAKIDAAVKAHADTIMDLSVRGPIEEMREKVLSTVDRPVGTLPMYETLSVAEAKYGTALDMTPDDMFDMIEKQASQGVAFIAVHPGTTLSVIHRAKDEGRIDPLVSYGGSHLIGWMLYNNTENPLYTEFDRLIEICKKYDVVLSFADGMRPGCIADSLDHAQVEELVILGGLVRRAREAGVQVMVKGPGHVPLDEIATTVQLEKKLCYGAPYFVFGCLPTDAAAGYDHITSAIGGAVAAYAGADFLCYVTPAEHIGMPNVDDVYQGVMASRIAAHAGDVAKGHPQAVKWDLDMSVARRAMNWKEQFKLSIDPETAERVWRERSTSFTSECTMCGKYCAMKIVEKYLRAE