Together with BzaB, catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of dimethylbenzimidazole (DMB), the lower axial ligand of vitamin B12 (cobalamin). Requires BzaB for catalytic activity, as BzaA alone displays no activity.

Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.

427 amino acids

MTLLEKAKCGEITAEMQYVAEKEGVRPEFICEGVANGDIVILYSSRENIHPVAVGKGLLTKVSASVGMYEEADTVDGEMAKIDAAVKAHADTIMDLSVRGPIEEMREKVLSTVDRPVGTLPMYETLSVAEAKYGTALDMTPDDMFDMIEKQASQGVAFIAVHPGTTLSVIHRAKDEGRIDPLVSYGGSHLIGWMLYNNTENPLYTEFDRLIEICKKYDVVLSFADGMRPGCIADSLDHAQVEELVILGGLVRRAREAGVQVMVKGPGHVPLDEIATTVQLEKKLCYGAPYFVFGCLPTDAAAGYDHITSAIGGAVAAYAGADFLCYVTPAEHIGMPNVDDVYQGVMASRIAAHAGDVAKGHPQAVKWDLDMSVARRAMNWKEQFKLSIDPETAERVWRERSTSFTSECTMCGKYCAMKIVEKYLRAE

46.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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