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aksA

Gene
aksA
Protein
Probable homocitrate synthase AksA
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
406 amino acids
Function
Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate.
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
45.365 kDa
Sequence
MTKVLVMFMDFLFENSWKAVCPYNPKLDLKDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKTIANEGLNADILALCRALKKDIDKAIECDVDGIITFIATSPLHLKYKFNNKSLDEILEMGVEAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADTTGCATPQSMEFICKTLKENLKKAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGNAALEELIMALTVLYDVDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGIHVDAVIENPLTYEPFLPEKIGLKRNILLGKHSGCRAVAYKLKLMGIDYDREMLCEIVKKVKEIREEGKFITDEVFKEIVEEVLRKRNKN
Protein
Probable homocitrate synthase AksA: aksA

Gene
aksA
Protein
Putative homocitrate synthase AksA
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
405 amino acids
Function
Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate (By similarity).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
45.021 kDa
Sequence
MSESEQYSRNTLMDFIEYRPLDIEICDVTLRDGEQTPGVVFTKEQKLAVASELDSMGIEVIEAGFPVVSAYEKEIVKEIANQGYDSRICCLSRAVKGDVDAALDCDVDIVSIFIAMSDMHLKYKYHRTLEDMLGCAKEAIEYATDHGLNVRFAAEDASRTPIDRLKQAFKEVENEYKVQYVSLADTIGILNPTTTHYLVSEIFKCVNTSICIHCHDDLGMATANTLAAAEAGAKQLHTTVNGIGERAGNASLEEMLVALRVQYGIERYDTTKLTALSRMISEYSNITPSVNKAVVGQNAFTHESGIHVAAILEEPRTYELFLPEMVGGKRNLVVGKHTGTKALKGIINSIGFCLEREELCALIEKVKVCTDEKRRSISREQLEKLIAQVRQEQKPSASEKEKFSI
Protein
Putative homocitrate synthase AksA: aksA

Gene
aksA
Protein
Putative homocitrate synthase AksA
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
405 amino acids
Function
Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate (By similarity).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
44.782 kDa
Sequence
MSESEQYSRNTLMDFIDYRPLDIEICDVTLRDGEQTPGVVFSKEQKLAVASELDSMGIEVIEAGFPVVSADEKEIVKEIANQGFNSRICCLSRAVKGDVDAALECDVDIVSIFIAMSDMHLKYKYHRSLEDMLGCAKEAIEYATDHGLKVRFAAEDASRTPVERLKQAFKEVENEYKVQYVSLADTVGILNPTTTNYLVSEIFKSVNTAICIHCHDDLGMATANTLAAAEAGAKQLHTTVNAIGERAGNASLEEVLVALRVQYGIERYDTTKLNSLSEMVSEYSGITPSVNKAVVGKNAFTHESGIHVAAILEEPRTYELFLPEMVGGKRNLVVGKHTGKKALKGIINSIGFCLEREELCALIEKVKVCTEEKHKSISRDQLERLITQVKQEQKPSGSEKEKFSI
Protein
Putative homocitrate synthase AksA: aksA

Gene
aksA
Protein
Putative homocitrate synthase AksA
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
397 amino acids
Function
Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate (By similarity).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
43.75 kDa
Sequence
MQSPYVREAVREMDLPDEVIVYDTTLRDGEQTPGVSFTPEQKLEIAHLLDELGVQQIEAGFPVVSEGERDAVRRIAHEGLNADILCLARTLRGDVDAALDCDVDGVITFIATSELHLKHKLRMSREEVLERIADTVEYAKDHGLWVAFSAEDGTRTEFEFLERVYRTAEECGADRVHATDTVGVMIPAAMRLFVAKIREVVDLPIGVHCHDDFGMAVANSLAAVEAGAQAISTTVNGIGERAGNAALEEVIMALKELYGIDPGFNTEVLAELSRKVSEYSGIDVPPNKAVVGENAFRHESGIHVAAVLEEPRTYEPIDPKEVGMNRKIVLGKHTGRKAVVAKLEELGVEPEEEIVEEVLKRIKALGDRRVRVTDSKLEEIVRNVLESRGDRDDPGSR
Protein
Putative homocitrate synthase AksA: aksA

Gene
aksA
Protein
Putative homocitrate synthase AksA
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
391 amino acids
Function
Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate (By similarity).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
43.966 kDa
Sequence
MRYFVSPFNKEAELKFPDRITIYDTTLRDGEQTPGVCLGTEEKLEIARKLDELGIHQIESGFPVVSEQERVSVKSIANEGLNAEILALCRTKKDDIDAAIDCDVDGVITFMATSDLHLKHKLKLTREEALNVCMNSIEYAKDHGLFLAFSAEDATRTDLDFLKQIYRKAENYGADRVHIADTVGAISPQGMDYLVRELRRDIKVDIALHCHNDFGMALSNSIAGLLAGGTAVSTTVNGIGERAGNTSLEELIMALRIIYEVDLGFNIGVLYELSRLVEKHTRMKVPENKPIVGRNVFRHESGIHVDAVIEEPLTYEPFLPEMIGHQRKIVLGKHSGCRAVKAKLEEYGIDVTRDELCRIVEEVKKNREKGKYINDELFYRIVKSVRGPVDF
Protein
Putative homocitrate synthase AksA: aksA