Protein
UDP-sulfoquinovose synthase
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Function
Catalyzes the biosynthesis of UDP-sulfoquinovose by the transfer of sulfite to UDP-glucose (PubMed:22059775, PubMed:25605538). Important for the assembly of the S-layer N-glycans (PubMed:22059775). The reaction probably occurs through an NAD(+)-dependent oxidation/dehydration/enolization/sulfite addition process (PubMed:25605538). In vitro, in the absence of sulfite, UDP-D-glucose is converted via UDP-4-keto-D-glucose to UDP-D-glucose-5,6-ene (PubMed:25605538).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Sequence
MRILVLGIDGHLGWPLALRLAKRGHEVIGIDNLSTRRFSEEVGSDSAFPLPQPQERVSEAKKHLGVDITFYVGDITNYGFFKDIVQRYKPDAIVHFAEQRSAPYSMIDMDHAVYTVINNEVSTLRVIQAVLEVDPTIHILKMGTMGEYGTPAFDIPESIYVEAIVNGKKDKIIVPRKAGSVYHWTKVHDTDFLLHFQELYGLTVTDIMQGPVYGTRTEEIVEETLRTRFDFDEVWGTVVNRYCVEAILGLPLTVYGKGGQTRGFISLEDSIQALTLLLENPPKQGEYRVANQFAEIYSVKKIAEFVKKAGEELGLNVEIGSYENPRVEAEEHYYNPERKVLPSLGFYPKKRLPEDVKIMIKDLLPYKTRLERFKHVILPKTKWRKPQYVKRVR