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abo

Gene
abo
Protein
4-methylaminobutanoate oxidase (formaldehyde-forming)
Organism
Paenarthrobacter nicotinovorans
Length
824 amino acids
Function
Catalyzes the oxidative demethylation of 4-methylaminobutanoate produced from the pyrrolidine ring of nicotine. To a much lesser extent, can also use sarcosine as substrate, but is not active against dimethylglycine, methylaminopropionitrile, methylaminopropylamine, and alpha-methylaminobutanoate.
Similarity
Belongs to the GcvT family.
Mass
89.418 kDa
Sequence
MDRLVDRDISASMFTATSHDPLPTHVRTVVVGGGIIGASIAYHLSAAGENDTLLLESNVLGSGTSWHAAGLVTGARGTTTMTKLAKYGLDFYSRLEQMSGLDVSFQRCGSLSVARTAGRVDELLYAKDVADQQGVRTEWLTEDRYKELWPLATYSGVAGALLLPDDGHINPGHATVALAKLAHSLGTQIRENVAVHKVLRQGDLVVGVLTDQGIVHCDRVILACGLWTRDLAATAGVKVPLYAAEHIHVRSAEIDGAVPELPVYRDLDNSYYIRHEAGRLLVGAFEPDGLPRPVEEIPSNGFAEFGPEWEHFAPIRAKAEGVVPALASAGFDRFLNAPESFTPDANFAVGETSELSNLFVAAGFNSQGIIFAPGIGKELAEWVISGTPGFDSSAVDVQRFSGHQNNRNYLKARTKEGLGRLYAMHWPNLQMETGRNVRRTPLHARLAELGACFGEVNGGERANWYGAPGTSPTYDYSYGRPNWFDRVAEEHKAAREGVVLFDLSPFAKFEVAGPDALEVCQMAATADIDVETDKAVYTLFLNDRAGIELDGTITRLGLDRFLVVTPSFTQQKTAAYLKRIARGKAAAVFDCTAALATIGVMGPKSRELLSRISPEDWSDEAQRYTHGRMVEIADGYAYSLRVSFVGELGYELYPSADMAVNVLDALWEAGQDLGLKLAGYHALDSLRSEKGFRHLGHDIGPIDDPYSAGLRFTISMDKPGGFLGKDALLKLDPTAPDHRTVYVALEDPDPVFVHDETVYCNGLPVGRMTSGSYGHTLGRAVGIAALEPDADLSGDFEVQCKGRLYPAKVSRRPFYDPKGERLRG
Protein
4-methylaminobutanoate oxidase (formaldehyde-forming): abo

Gene
abo
Protein
4-methylaminobutanoate oxidase (formaldehyde-forming)
Organism
Paenarthrobacter nicotinovorans
Length
824 amino acids
Function
Catalyzes the oxidative demethylation of 4-methylaminobutanoate produced from the pyrrolidine ring of nicotine. To a much lesser extent, can also use sarcosine as substrate, but is not active against dimethylglycine, methylaminopropionitrile, methylaminopropylamine, and alpha-methylaminobutanoate.
Similarity
Belongs to the GcvT family.
Mass
89.418 kDa
Sequence
MDRLVDRDISASMFTATSHDPLPTHVRTVVVGGGIIGASIAYHLSAAGENDTLLLESNVLGSGTSWHAAGLVTGARGTTTMTKLAKYGLDFYSRLEQMSGLDVSFQRCGSLSVARTAGRVDELLYAKDVADQQGVRTEWLTEDRYKELWPLATYSGVAGALLLPDDGHINPGHATVALAKLAHSLGTQIRENVAVHKVLRQGDLVVGVLTDQGIVHCDRVILACGLWTRDLAATAGVKVPLYAAEHIHVRSAEIDGAVPELPVYRDLDNSYYIRHEAGRLLVGAFEPDGLPRPVEEIPSNGFAEFGPEWEHFAPIRAKAEGVVPALASAGFDRFLNAPESFTPDANFAVGETSELSNLFVAAGFNSQGIIFAPGIGKELAEWVISGTPGFDSSAVDVQRFSGHQNNRNYLKARTKEGLGRLYAMHWPNLQMETGRNVRRTPLHARLAELGACFGEVNGGERANWYGAPGTSPTYDYSYGRPNWFDRVAEEHKAAREGVVLFDLSPFAKFEVAGPDALEVCQMAATADIDVETDKAVYTLFLNDRAGIELDGTITRLGLDRFLVVTPSFTQQKTAAYLKRIARGKAAAVFDCTAALATIGVMGPKSRELLSRISPEDWSDEAQRYTHGRMVEIADGYAYSLRVSFVGELGYELYPSADMAVNVLDALWEAGQDLGLKLAGYHALDSLRSEKGFRHLGHDIGPIDDPYSAGLRFTISMDKPGGFLGKDALLKLDPTAPDHRTVYVALEDPDPVFVHDETVYCNGLPVGRMTSGSYGHTLGRAVGIAALEPDADLSGDFEVQCKGRLYPAKVSRRPFYDPKGERLRG
Protein
4-methylaminobutanoate oxidase (formaldehyde-forming): abo

Gene
ABO
Protein
Histo-blood group ABO system transferase
Organism
Homo sapiens
Length
354 amino acids
Function
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Similarity
Belongs to the glycosyltransferase 6 family.
Mass
40.934 kDa
Sequence
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
Protein
Histo-blood group ABO system transferase: ABO

Gene
Abo
Protein
Histo-blood group ABO system transferase 1
Organism
Rattus norvegicus
Length
348 amino acids
Function
Posseses strong A transferase activity and a weak B transferase activity.
Similarity
Belongs to the glycosyltransferase 6 family.
Mass
40.375 kDa
Sequence
MDLRGRPKCYSLHLGILPFIVLVLVFFGYGFLSHKIQEFRNPGGETCMATRQTDVQKVVSVPRMAYPQPNVLTPIRNDVLVFTPWLAPIIWEGTFNIDILNEQFKLQNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPSDVPQVPLGAGRKLVVLTVRNYTRWQDVSMHRMEMISHFSEQRFQHEVDYLVCGDVDMKFSDHVGVEILSALFGTLHPGFYRSRRESFTYERRPKSQAYIPRDEGDFYYAGGFFGGSVVEVHHLTKACHQAMVEDQANGIEAVWHDESHLNKYLLYHKPTKVLSPEYVWDQKLLGWPSIMKKLRYVAVPKNHQAIRN
Protein
Histo-blood group ABO system transferase 1: Abo

Gene
Abo
Protein
Histo-blood group ABO system transferase
Organism
Mus musculus
Length
332 amino acids
Similarity
Belongs to the glycosyltransferase 6 family.
Mass
38.777 kDa
Sequence
MNLRGRPKCNFLHLGILPFAVFVLVFFGYLFLSFRSQNLGHPGAVTRNAYLQPRVLKPTRKDVLVLTPWLAPIIWEGTFNIDILNEQFRIRNTTIGLTVFAIKKYVVFLKLFLETAEQHFMVGHKVIYYVFTDRPADVPQVILGAGRQLVVLTVRNYTRWQDVSMHRMEMISHFSERRFLREVDYLVCADADMKFSDHVGVEILSTFFGTLHPGFYSSSREAFTYERRPQSQAYIPWDRGDFYYGGAFFGGSVLEVYHLTKACHEAMMEDKANGIEPVWHDESYLNKYLLYHKPTKVLSPEYLWDQQLLGWPSIMKKLRYVAVPKDHQAIRN
Protein
Histo-blood group ABO system transferase: Abo