Catalyzes the oxidative demethylation of 4-methylaminobutanoate produced from the pyrrolidine ring of nicotine. To a much lesser extent, can also use sarcosine as substrate, but is not active against dimethylglycine, methylaminopropionitrile, methylaminopropylamine, and alpha-methylaminobutanoate.

Belongs to the GcvT family.

824 amino acids

MDRLVDRDISASMFTATSHDPLPTHVRTVVVGGGIIGASIAYHLSAAGENDTLLLESNVLGSGTSWHAAGLVTGARGTTTMTKLAKYGLDFYSRLEQMSGLDVSFQRCGSLSVARTAGRVDELLYAKDVADQQGVRTEWLTEDRYKELWPLATYSGVAGALLLPDDGHINPGHATVALAKLAHSLGTQIRENVAVHKVLRQGDLVVGVLTDQGIVHCDRVILACGLWTRDLAATAGVKVPLYAAEHIHVRSAEIDGAVPELPVYRDLDNSYYIRHEAGRLLVGAFEPDGLPRPVEEIPSNGFAEFGPEWEHFAPIRAKAEGVVPALASAGFDRFLNAPESFTPDANFAVGETSELSNLFVAAGFNSQGIIFAPGIGKELAEWVISGTPGFDSSAVDVQRFSGHQNNRNYLKARTKEGLGRLYAMHWPNLQMETGRNVRRTPLHARLAELGACFGEVNGGERANWYGAPGTSPTYDYSYGRPNWFDRVAEEHKAAREGVVLFDLSPFAKFEVAGPDALEVCQMAATADIDVETDKAVYTLFLNDRAGIELDGTITRLGLDRFLVVTPSFTQQKTAAYLKRIARGKAAAVFDCTAALATIGVMGPKSRELLSRISPEDWSDEAQRYTHGRMVEIADGYAYSLRVSFVGELGYELYPSADMAVNVLDALWEAGQDLGLKLAGYHALDSLRSEKGFRHLGHDIGPIDDPYSAGLRFTISMDKPGGFLGKDALLKLDPTAPDHRTVYVALEDPDPVFVHDETVYCNGLPVGRMTSGSYGHTLGRAVGIAALEPDADLSGDFEVQCKGRLYPAKVSRRPFYDPKGERLRG

89.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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