Zc3h8

Zinc finger CCCH domain-containing protein 8

305 amino acids

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene.

34.913 kDa

MDFENLFSKPPNPALGKKPAADPEERIDEIDGTEVEETQTEKVKWKVKRDREQIPKKFKHLGNAATSPKSLLRKKSRSKDYDPYSDGETCSQGSEDNFDKELQQYIQAKEMANAAQPSLLPEESVKKAGAEGTQQTAKQKNKKSKAGHKKVKQKKMKRKWPGTGDKGSRALLKNSGSREQTDEPEEKQPRVRMSQGFINQHTVERKGKQVCKYFLERKCIKGDQCKFDHDAEIEKKKEMCKYYVQGYCTKGENCLYLHSEYPCKFYHTGTKCYQGDHCNFSHAPLTAETQELLAKVLDTDKKSCK

ZC3H8

Zinc finger CCCH domain-containing protein 8

291 amino acids

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

33.576 kDa

MDFENLFSKPPNPALGKTATDSDERIDDEIDTEVEETQEEKIKLECEQIPKKFRHSAISPKSSLHRKSRSKDYDVYSDNDICSQESEDNFAKELQQYIQAREMANAAQPEESTKKEGVKDTPQAAKQKNKNLKAGHKNGKQKKMKRKWPGPGNKGSNALLRNSGSQEEDGKPKEKQQHLSQAFINQHTVERKGKQICKYFLERKCIKGDQCKFDHDAEIEKKKEMCKFYVQGYCTRGENCLYLHNEYPCKFYHTGTKCYQGEYCKFSHAPLTPETQELLAKVLDTEKKSCK