Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene.

305 amino acids

MDFENLFSKPPNPALGKKPAADPEERIDEIDGTEVEETQTEKVKWKVKRDREQIPKKFKHLGNAATSPKSLLRKKSRSKDYDPYSDGETCSQGSEDNFDKELQQYIQAKEMANAAQPSLLPEESVKKAGAEGTQQTAKQKNKKSKAGHKKVKQKKMKRKWPGTGDKGSRALLKNSGSREQTDEPEEKQPRVRMSQGFINQHTVERKGKQVCKYFLERKCIKGDQCKFDHDAEIEKKKEMCKYYVQGYCTKGENCLYLHSEYPCKFYHTGTKCYQGDHCNFSHAPLTAETQELLAKVLDTDKKSCK

34.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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