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XPB

Gene
XPB
Protein
TFIIH basal transcription factor complex helicase XPB subunit
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Length
938 amino acids
Function
ATP-dependent 3'-5' DNA helicase, component of the general transcription factor IIH (TFIIH) core complex, involved in spliced leader RNA (SL RNA) gene transcription by RNA polymerase II (PubMed:17259543). TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB is required for promoter opening and promoter escape (By similarity).
Similarity
Belongs to the helicase family. RAD25/XPB subfamily.
Mass
105.211 kDa
Sequence
MILGPGGRIFINHGHPAYPHLMDFLTACCEPVCRTLYVSEYTISPSSLSAATAEGTYSMEMVRNVIRYFRLDEQQQIPVDVERYAALERRVRDSVQDTSLDLPMEVGEAKVSANGDVKAEEGCEEATDELSPLAGQVKKEETKEVAAEPRRRFLSLSKRISAKSEPLVTRAVVNTGALQPLPADLEQMLREEENSSRVRIVLQPCLRPVKRRAVGGDKQHSDEQQCQRAEETKLAYFLTSPDRNHMEHLVSRLQDFLVPVLLHGTRRWVVSDVDRGVEERSTAESGRAKTLRRLFEAPSSASGRSVASKSLTNEGANGDGLGGGVGRRCTRIVYKSQVMDGKMRNVRERLYKELSVRADLFYDYVQDHSLHVCDLELSENVRLRPYQVASLERFRSGNKAHQGVIVLPCGAGKTLTGIGAAATVKKRTIVMCINVMSVLQWQREFIRWTNLSEDQVTVCIADKKQMPGDVFITTYSMLIARRSNVPEMEQSADAKLTAKILASVGEQPWGLLLLDEVHTALAHNFQEVLNKVKYKCVIGLSATLLREDDKIGDLRHLVGPKLYEANWLDLTRAGFLARVECAEIQCPLPKAFLTEYLESQSDGDPFARRGTTRMAHSVVCLNPYKLWCTQALLEFHRNRSPPDKVIIFCDQIDGIQYYAQHLHVPFMDGKTSDMERENLLQYFQHSDNINAIILSRVGDVALDIPCASVVIQISGLGASRRQEAQRLGRILRPKPASLDNVCSYFYTLVSQDTHEISQSYERQSWLRDQGFSYRVLQSDMVLQHFLRTGGKLCCVGPPRWWYECAGPSCDSAVAAKGTYWIPFSQEAALRMQSRFVAGVRGCDLTATVLRDTPRPPELKNMGVEEKWTVCFSDSCAPETFGTVQLVEGNPLLVRRICCGPLAVEHDCLHGGEECLQYAVQQMKVMVAKNSKNRIPLTT