ATP-dependent 3'-5' DNA helicase, component of the general transcription factor IIH (TFIIH) core complex, involved in spliced leader RNA (SL RNA) gene transcription by RNA polymerase II (PubMed:17259543). TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB is required for promoter opening and promoter escape (By similarity).

Belongs to the helicase family. RAD25/XPB subfamily.

938 amino acids

MILGPGGRIFINHGHPAYPHLMDFLTACCEPVCRTLYVSEYTISPSSLSAATAEGTYSMEMVRNVIRYFRLDEQQQIPVDVERYAALERRVRDSVQDTSLDLPMEVGEAKVSANGDVKAEEGCEEATDELSPLAGQVKKEETKEVAAEPRRRFLSLSKRISAKSEPLVTRAVVNTGALQPLPADLEQMLREEENSSRVRIVLQPCLRPVKRRAVGGDKQHSDEQQCQRAEETKLAYFLTSPDRNHMEHLVSRLQDFLVPVLLHGTRRWVVSDVDRGVEERSTAESGRAKTLRRLFEAPSSASGRSVASKSLTNEGANGDGLGGGVGRRCTRIVYKSQVMDGKMRNVRERLYKELSVRADLFYDYVQDHSLHVCDLELSENVRLRPYQVASLERFRSGNKAHQGVIVLPCGAGKTLTGIGAAATVKKRTIVMCINVMSVLQWQREFIRWTNLSEDQVTVCIADKKQMPGDVFITTYSMLIARRSNVPEMEQSADAKLTAKILASVGEQPWGLLLLDEVHTALAHNFQEVLNKVKYKCVIGLSATLLREDDKIGDLRHLVGPKLYEANWLDLTRAGFLARVECAEIQCPLPKAFLTEYLESQSDGDPFARRGTTRMAHSVVCLNPYKLWCTQALLEFHRNRSPPDKVIIFCDQIDGIQYYAQHLHVPFMDGKTSDMERENLLQYFQHSDNINAIILSRVGDVALDIPCASVVIQISGLGASRRQEAQRLGRILRPKPASLDNVCSYFYTLVSQDTHEISQSYERQSWLRDQGFSYRVLQSDMVLQHFLRTGGKLCCVGPPRWWYECAGPSCDSAVAAKGTYWIPFSQEAALRMQSRFVAGVRGCDLTATVLRDTPRPPELKNMGVEEKWTVCFSDSCAPETFGTVQLVEGNPLLVRRICCGPLAVEHDCLHGGEECLQYAVQQMKVMVAKNSKNRIPLTT

105.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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