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WDPCP

Gene
WDPCP
Protein
WD repeat-containing and planar cell polarity effector protein fritz homolog
Organism
Homo sapiens
Length
746 amino acids
Function
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
Similarity
Belongs to the WD repeat fritz family.
Mass
85.084 kDa
Sequence
MRREFCWDAYSKAAGSRASSPLPRQDRDSFCHQMSFCLTELHLWSLKNTLHIADRDIGIYQYYDKKDPPATEHGNLEKKQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRVVCWWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVARKRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMTNTCNAEDGELREDGREQEIRDGGSLKMIHFGLV

Gene
Wdpcp
Protein
WD repeat-containing and planar cell polarity effector protein fritz homolog
Organism
Rattus norvegicus
Length
726 amino acids
Function
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
Similarity
Belongs to the WD repeat fritz family.
Mass
81.91 kDa
Sequence
MSFCLTELHLWSLKSTLHIADRDIGVYQYYDKKDLPVSAAEHGNLEEKQRLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSQCVLCQWKSKHICQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFAKKMDSLDVNKRLEKLSALDYKISYHDIPGPATRTVDRHLAINSTQDLAVCWWPLLSDDAWPWTPIASEKDRANMLLLGFTQGGLEVLSSVRTEWNPLDVHFGTRQPYQVFTVECSFSVDQEPMADSCIYESVRNKLHCVSVTRIPLRSKAISCCKNSTEDKLIVGCEDSSVILYEAHRGVTLLAQAELMPSLISCHPSGAILLVGSNQGELQVFDIALSPINIQLLAEDCLPKETLQFNKFFDFSSSLVHMQWIAPPIVFQKPKRGEICDLLFLRFNRGPLGVLLFKLGVLRRGQLGLVDLIFQYIHCDEVYEAVSVLSSMNWDTLGQQCFISMSTIVNHLLRQRLTPEREAQLEASLGTFYAPARPLLDTTVLAYRDPVGTYARRLFHHLLRYQRFEKAFLLAVDIGARDLFMDIHYLALDMGELALAEVARRRADDIDVESVCSGVELLGPLDRRDMLNEGFAGSALTPEGGNPFPDLLPSSGSTPKHTIQQKIPNGPSNRRAIERKNEVMEETEEEEEEEEEAAACTDSSVATTWDAEGELREDHRRQDTEDVGSLRMVHFGLV

Gene
Wdpcp
Protein
WD repeat-containing and planar cell polarity effector protein fritz homolog
Organism
Mus musculus
Length
722 amino acids
Function
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).
Similarity
Belongs to the WD repeat fritz family.
Mass
81.731 kDa
Sequence
MSFCLTELHLWSLKSTLHIADRDIGVYQYYDKKDPSVSATEHGNLEEKQRLAESRDYPWTLKNRRPEKLRDSLKELEELMQSSPCVLSKWKSKYICQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMDSLDGNKRLEKLSALDLKISYYDIPGPANRTIDRHLAVNSTQDLVVCWWPLVSDDVWPWTPVSSEKDRANMLLLGFTQGGLEVLSFVRTEWSPLDVHFGTKQPYQVFTVECSVSVDKEPMADSCIYESVRNKLHCVSVTRIPLRSKAISCCRNSTEDKLIVGCEDSSVILYEAHRGVTLLAQAELRPSLISCHPSGAILLVGSNQGELQIFDIALSPINIQLLAEDYSPKETLQFKKFFDVSSSLVQMQWMAPPVVFQKPKRGEICDLLFLRFNKGPLGVLLFKLGILTRGQLGLVDLILQYIHYSEVYEAISILRSMDWDTLGQQCLIGMGTIVNHLLRQRLTPEREAQLEASLGTFYAPTRPLLDTTILEYREPVSKYARRLFHHLLRYKRFEKAFLLAVDIGARDLFMDIHYLALDMGELALAEVARRRAHDIDVESVSSGVELLGPLDRRDMLNEGFASSALMPEGENKFPGLLPSIGSTHMQTLQQKIPNGPSSRWAIERRTEEEEEEEEEEEEELCTDSSGATTWNAEGELKEDQRKQDIGDVGSLRMVHFGLV

Gene
wdpcp
Protein
WD repeat-containing and planar cell polarity effector protein fritz homolog
Organism
Xenopus laevis
Length
708 amino acids
Function
Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements including covergent extension during gastrulation. Controls cell shape but not polarization during convergent extension (PubMed:20671153). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies.
Similarity
Belongs to the WD repeat fritz family.
Mass
80.249 kDa
Sequence
MSFCLTELYLWSLKNNLHIGDEDVGVHQYHEKKEAALHPDYGFLEEKQQWMESRGFPWILKNKRPEKLRDNLTELEELMQSSECVLSKWKNKYVCQLLFGSGVLVSISLSGPQLEKVVIDRSLVGKLISNPISDAIFTDSFIILSFLKENKLCLIQFTKKINSPDINRQLDKLSLLDLKISYTDIPGPKGRHLVRHLAINSMQDLALCWWPVPVDDVKPWSPVSSEKDRANLVLLSNSSCKLEVLSYIRTEGDLLNACFSINQPYQICTVEHSLNSNKEPMADRFIYECVRNKIQCVSVTRVPLRSRVISCAVNTSEDKLVLGCEDSSLILYESDCKVTLLAQADLLPDLIRWHPNGTIFVVASSQGELQIFDMALSPIRAQILAEEIEPNSTIQVCKQFNVSSTLVEMHWAAPHTLLQNMDMTDIYNLLYLRFDGGPIGVLQLKLGAICRGQLGAMEIISQYIRHDEVDEAVGLLSSMNWNTMGHQCFTSMTAIVNHLLRQRLTPDREAQLEASLGTFYSPTRPLLDTIVLQYRDPISRYARRFFHHLLRYQRFEKAFLLAVDIGARDLFMDIHYLALDKGELALAKVARKKAEEIDAESINSGVEPLLPTDTLADVNEAFVDLSLIPQVEDRILGSFPSTDLGAHNSIQRNANRQLVHIENEIGIEVYAESLDKSLPWNQECFEEDFAEENPEGIGSLKVVHFGLV