About Products Protein Database Contact

UROS

Gene
UROS
Protein
Uroporphyrinogen-III synthase, chloroplastic
Organism
Arabidopsis thaliana
Length
321 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
34.225 kDa
Sequence
MALLLLSHCSILSFQPPLSSSSSFHSSHIQSLSKPVFASPSPIRNSISSSVSSSSSSVSSSNSIPQVVVTRERGKNNQIIKALEKNGISSLELPLIQHARGPDFDRLASVLNDKSFDWIIITSPEAGSVFLEAWKTASSPEVQIGVVGAGTARVFEEAMKSADGLLHVAFTPSKATGKVLASELPEKVGKRSSVLYPASLKAGNDIVEGLSKRGFEVVRLNTYTTVPVQSVDTVLLQQALSAPVLSVASPSAVRAWLHLIQNEEQWSNYVACIGETTASAARRLGLKNVYYPEKPGLEGWVESIMEALGAHADSSNPSSRN

Gene
UROS
Protein
Uroporphyrinogen-III synthase, chloroplastic
Organism
Oryza sativa subsp. japonica
Length
302 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins.
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
32.123 kDa
Sequence
MALSSSSHLLPFSRPPATFPRARHAGGGRGRAGATGRFIACSSPPPPDVVVTRERGKNAKLIAALEKHNVQSLELPLIKHVEGPDTDRLSAVLRDEKFDWITITSPEAAAVFLEGWKAAGNPKVRIAVVGAGTERVFDEVIQYNDGSLEVAFSPSKAMGKFLASELPRTTETTCKVLYPASAKAGHEIQNGLSNRGFEVTRLNTYTTVSVQDVDPLILKPALSAPVVAVASPSALRAWLNLASQVDNWGNAIACIGETTASAAKKFGLKSIYYPTTPGLDGWVESILEALRAHGQSKEAPGC

Gene
UROS
Protein
Uroporphyrinogen-III synthase
Organism
Homo sapiens
Length
265 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
28.628 kDa
Sequence
MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC

Gene
Uros
Protein
Uroporphyrinogen-III synthase
Organism
Mus musculus
Length
265 amino acids
Function
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity).
Similarity
Belongs to the uroporphyrinogen-III synthase family.
Mass
28.504 kDa
Sequence
MKVLLLKDAKEDDSGLDPYIQELRLCGLEATLIPVLSFEFMSLPSLSEKLSHPEGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLDAEGAGSGNAEKLAEYICSKPSSELPLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTVPHPGIQGSLKSYYEDQGIPASITFFSPSGLKYSLEYIQALSGSSFDQIKFIAIGPSTTRAMAAKGLPVSCTAESPTPQALAAGIRNVLKPNHCC