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Tmem97

Gene
Tmem97
Protein
Sigma intracellular receptor 2
Organism
Rattus norvegicus
Length
176 amino acids
Function
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
Similarity
Belongs to the TMEM97/sigma-2 receptor family.
Mass
20.946 kDa
Sequence
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK

Gene
TMEM97
Protein
Sigma intracellular receptor 2
Organism
Bos taurus
Length
176 amino acids
Function
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
Similarity
Belongs to the TMEM97/sigma-2 receptor family.
Mass
20.784 kDa
Sequence
MGTLGARRGLEWFLGFYFLSHIPITLLMDLQGVLPRDLYPVELRNLQQWYIEEFKDPLLQTPPAWFKSFLFCELVFQLPFFPIAAYAFFKGGCKWIRTPAIIYSVHTMTTLIPILSTLLLDDFSKASHFRGQGPKTFQERLFLISVYIPYFLIPLILLLFMVRNPYYKSEEKRKKK

Gene
TMEM97
Protein
Sigma intracellular receptor 2
Organism
Homo sapiens
Length
176 amino acids
Function
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).
Similarity
Belongs to the TMEM97/sigma-2 receptor family.
Mass
20.848 kDa
Sequence
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK

Gene
Tmem97
Protein
Sigma intracellular receptor 2
Organism
Macaca fascicularis
Length
176 amino acids
Function
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
Similarity
Belongs to the TMEM97/sigma-2 receptor family.
Mass
20.89 kDa
Sequence
MGVPATRRCVEWLLGIYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLISVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK

Gene
Tmem97
Protein
Sigma intracellular receptor 2
Organism
Mus musculus
Length
176 amino acids
Function
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
Similarity
Belongs to the TMEM97/sigma-2 receptor family.
Mass
20.811 kDa
Sequence
MGALAARRCVEWLLGLYFVSHIPITLFIDLQAVLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLLCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAAHTITTLIPILYTLLFEDFSKAVAFKGQRPESFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKYEEKRKKK

Gene
tmem97
Protein
Sigma intracellular receptor 2
Organism
Xenopus tropicalis
Length
171 amino acids
Function
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
Similarity
Belongs to the TMEM97/sigma-2 receptor family.
Mass
19.846 kDa
Sequence
MAVCARLLEWIFFFYFFSHIPITLLVDLQAVLPPSLYPQELLDLMKWYTVAFKDHLMANPPPWFKSFVYCEAILQLPFFPVAAYAFFKGGCKWIRIPAIVYSAHVATTVIAIIGHILFGEFPKSDVIAPLTQKDRLTLVSIYAPYLLVPVLLLLTMLFSPRYRQEEKRKRK