Tti2

TELO2-interacting protein 2

512 amino acids

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity).

Belongs to the TTI2 family.

56.702 kDa

MKLDSAEEKSGVGCSLPAEGSPPALEPAFSKILNRLSRPKSSGQGGARNAALKDLGALIEAAEGDRFFEGSGSGGSLRGMPEILGQVVRALEKFAAPEEKADGVEEHPEVPEKATEVGSLFLKLLGKVEAAKSSPDCPAWKTGLRHMSGPVYIFAITHRLKQPWTSPASQHVAGEVLSLLLRVTECSSVAGFLCGENEDDRGRFAVVLGLLKPHLNKETWKKNPAVKHVFSWTLQQVTQPWLNQHLEKILPPSLLISDDYQTENKILGVQCLHHIVVTVPAADLLQYNRAQVLYHALFNHLYMPEHHLIQAVLLCLLDLFPVLEKALHWKGDTARVTTHCHEVLQLILTHMEPEHRLLLRRTYARHLPAFVKRLGILTVRHLKRLEQVILGYLEVYDEPEDETRLKILETLKLVMQYTWPRIPCRVVVLLKALLKLICDISRDTIPTTEAAKSTMLQEATDCLILLDHCSQGQVKGLLAKIAVSCEDSTVVSCIRKVQQGSADSPGDDTEGD

Tti2

TELO2-interacting protein 2

511 amino acids

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity).

Belongs to the TTI2 family.

56.436 kDa

MKLGSTEEKSGGGCSLPTEVSPPALQQAFSKILHGLSRQESSGQGNAGNAALRDLGALIEATECDKLFEGTGGGGSPREMPEILGQVAKALEKFAAPKEKADGSEEHPEVPEKATEVGLLFLKLLGKVETAKSSPVCPAWKTGLRHLSGPTYIFAITHRLKQPWTSPKSQHVAGEVLSLLFRVTECSSVAEFLCGENKDDRGRFAVVLGLLKPHLNKETWKKNPAVKHVFSWTLQQVTQPWLSQHLEKILPPSLLISDDYQTDNKVLGVQCLHHIVINVPAADLLQYNRAQVLYHALFNHLYMPEHRLIQAVLLCLLDLFPVLEKALHWQGEAARASTHCHEVLQLVLTHMESEHRLLLRRTYARNLPAFVKKLGILTARHLKRLEQVILGYLEVYDEPEDESRLKILETLKLVMQYTWPRIPCRVVVLLKALLKLICDIARDTIPTTEAAKSAVLQEATDCLILLDHCSQGQVKGLLANIALSCDDSTVVSCIRKVQGSAEAPGEDPGDD

TTI2

TELO2-interacting protein 2

508 amino acids

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.

Belongs to the TTI2 family.

56.915 kDa

MELDSALEAPSQEDSNLSEELSHSAFGQAFSKILHCLARPEARRGNVKDAVLKDLGDLIEATEFDRLFEGTGARLRGMPETLGQVAKALEKYAAPSKEEEGGGDGHSEAAEKAAQVGLLFLKLLGKVETAKNSLVGPAWQTGLHHLAGPVYIFAITHSLEQPWTTPRSREVAREVLTSLLQVTECGSVAGFLHGENEDEKGRLSVILGLLKPDLYKESWKNNPAIKHVFSWTLQQVTRPWLSQHLERVLPASLVISDDYQTENKILGVHCLHHIVLNVPAADLLQYNRAQVLYHAISNHLYTPEHHLIQAVLLCLLDLFPILEKTLHWKGDGARPTTHCDEVLRLILTHMEPEHRLLLRRTYARNLPAFVNRLGILTVRHLKRLERVIIGYLEVYDGPEEEARLKILETLKLLMQHTWPRVSCRLVVLLKALLKLICDVARDPNLTPESVKSALLQEATDCLILLDRCSQGRVKGLLAKIPQSCEDRKVVNYIRKVQQVSEGAPYNGT

TTI2

TEL2-interacting protein 2

421 amino acids

Component of the ASTRA complex probably in chromatin remodeling.

Belongs to the TTI2 family.

48.649 kDa

MTAVTDIIDELNDSSLSSTRLRELCLQLRKKTDTGCAITVSDEVNLIESLSYHSISPGVDIQINTDVLQTIDYYFQRNKSEHDEIMCVLISKLQPLLLKRKSNFELKEQRNLGLKPTLGMSLKEDNLMQAWVSQGGLKGIPLFYVILLHLKRRDISTNLSWIIPGILNILDDTTDIRRIKLRGVLLLQTLLNHTFMNETNDSKWIQFSSTGLFPLFEKTLINMCYFLPPSYNADETIAIWRVVFPTIQSLYKVEFLDNYTKYQYHLEKFMSEIILQNIIPRASLAYENLTLYALECTMNILRLQREGSVVHLQRLIFVLGEYIVRNPFYTTFPKLISKTLSVVSTLIKVCPNERIVAHRFDILSLILVTYDKCSQEDALNESILQQCKETISWLLNCDCAMGEQLSTLSKQPRFQLLFEFS