Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity).

Belongs to the TTI2 family.

511 amino acids

MKLGSTEEKSGGGCSLPTEVSPPALQQAFSKILHGLSRQESSGQGNAGNAALRDLGALIEATECDKLFEGTGGGGSPREMPEILGQVAKALEKFAAPKEKADGSEEHPEVPEKATEVGLLFLKLLGKVETAKSSPVCPAWKTGLRHLSGPTYIFAITHRLKQPWTSPKSQHVAGEVLSLLFRVTECSSVAEFLCGENKDDRGRFAVVLGLLKPHLNKETWKKNPAVKHVFSWTLQQVTQPWLSQHLEKILPPSLLISDDYQTDNKVLGVQCLHHIVINVPAADLLQYNRAQVLYHALFNHLYMPEHRLIQAVLLCLLDLFPVLEKALHWQGEAARASTHCHEVLQLVLTHMESEHRLLLRRTYARNLPAFVKKLGILTARHLKRLEQVILGYLEVYDEPEDESRLKILETLKLVMQYTWPRIPCRVVVLLKALLKLICDIARDTIPTTEAAKSAVLQEATDCLILLDHCSQGQVKGLLANIALSCDDSTVVSCIRKVQGSAEAPGEDPGDD

56.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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