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TNFAIP8

Gene
TNFAIP8
Protein
Tumor necrosis factor alpha-induced protein 8
Organism
Bos taurus
Length
198 amino acids
Function
Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).
Similarity
Belongs to the TNFAIP8 family.
Mass
22.995 kDa
Sequence
MHFEAEESKEVATDVFNSKNLAVQAQKKILGKMASKSIATTLIDDTSSEVLDELYRVTKEYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDFTFDRNVLSKLLNECREMLHQIIQRHLTTKSHGRVNNVFDHFSDCDFLAALYNPFGNYKPHLQKLCDGINKMLDEENI

Gene
TNFAIP8
Protein
Tumor necrosis factor alpha-induced protein 8
Organism
Homo sapiens
Length
198 amino acids
Function
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Similarity
Belongs to the TNFAIP8 family.
Mass
23.003 kDa
Sequence
MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI

Gene
Tnfaip8
Protein
Tumor necrosis factor alpha-induced protein 8
Organism
Mus musculus
Length
198 amino acids
Function
Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).
Similarity
Belongs to the TNFAIP8 family.
Mass
22.96 kDa
Sequence
MLSEAEEPREVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTKEYTQNKKEAERVIKNLIKTVIKLAVLHRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVEYTFDRNVLSRLLNECRELLHEIIQRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGKFKPHLQKLCDGINKMLDEENI

Gene
TNFAIP8
Protein
Tumor necrosis factor alpha-induced protein 8
Organism
Pongo abelii
Length
198 amino acids
Function
Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).
Similarity
Belongs to the TNFAIP8 family.
Mass
23.017 kDa
Sequence
MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIRRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGNFKPHLQKLCDGINKMLDEENI

Gene
tnfaip8
Protein
Tumor necrosis factor alpha-induced protein 8
Organism
Xenopus laevis
Length
189 amino acids
Function
Acts as a negative mediator of apoptosis.
Similarity
Belongs to the TNFAIP8 family.
Mass
21.951 kDa
Sequence
MATDIFNSKNLAVQAQKKILGKMASSKYIATSLIDDTSGEVLDELYQVTREYTQNKKDAEKITKNLIKTVIKLAVLYRNNQFNEEEIGLMEKFKRKVHQLAMTVVSFYQVEYTFDRNVLSKLLNECRELLHQVIQRHLTAKSHGRVNNVFDHFSNCEFLAALYNPFGPYKKHLQRLCNGVNKMLDEDNI

Gene
tnfaip8
Protein
Tumor necrosis factor alpha-induced protein 8
Organism
Xenopus tropicalis
Length
189 amino acids
Function
Acts as a negative mediator of apoptosis.
Similarity
Belongs to the TNFAIP8 family.
Mass
21.938 kDa
Sequence
MATDVFSSKNLAVQAQKKILGKMASSKYIATSLIDDTSGEVLDELYQLTREYTQSKKESEKVIKNLIKTVIKLAVLYRNNQFNEEEIALMEKFKRKVHQLAMTVVSFYQVEYTFDRNVLSKLLNECRELLHQVIQRHLTAKSHGRVNNVFDHFSNCEFLAALYNPFGPFKQHLQRLCEGVNKMLDEDNI

Gene
TNFAIP8
Protein
Tumor necrosis factor alpha-induced protein 8
Organism
Gallus gallus
Length
188 amino acids
Function
Acts as a negative mediator of apoptosis.
Similarity
Belongs to the TNFAIP8 family.
Mass
21.776 kDa
Sequence
MATDVFNSKSLAIQAQKKILGKMVSKSIATTLIDDTSSDVLDELYRVTKEYTQNKKEAEKIIKNLIKIVLKLAILYRNNQFNQDEIALMEKFKKKVHQLAKTVVSFHQVDYTFDRNFLSKLLNDCRELLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGPYKLHLQKLCDGVNRMLDEGNI