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SSL7

Gene
SSL7
Protein
Protein STRICTOSIDINE SYNTHASE-LIKE 7
Organism
Arabidopsis thaliana
Length
371 amino acids
Similarity
Belongs to the strictosidine synthase family.
Mass
41.124 kDa
Sequence
MPVLFSSRSLILSIIVPLLISIALYKLDTFDPAIVPSDAFTSSATSLPPLINDEFLTGAEFIGVGLLNIPEDIAYHKESNLIYTGCVDGWVKRVKVADSVNDSVVEDWVNTGGRPLGIAFGIHGEVIVADVHKGLLNISGDGKKTELLTDEADGVKFKLTDAVTVADNGVLYFTDASYKYTLNQLSLDMLEGKPFGRLLSFDPTTRVTKVLLKDLYFANGITISPDQTHLIFCETPMKRCSKYYISEERVEVFTQSLPGYPDNIRYDGDGHYWIALPSGVTTLWNISLKYPFLRKLTAMVAKYGVDLMFMENAGVLQVDLDGNPIAYYHDPKLSHIATCDKIGKYLYCGSLSQSHILRLDLLKYPAQNKKL

Gene
ssl7
Protein
Staphylococcal superantigen-like 7
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
231 amino acids
Function
Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5 (PubMed:15728504). Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration (PubMed:20545943).
Similarity
Belongs to the staphylococcal/streptococcal toxin family.
Mass
26.168 kDa
Sequence
MKLKTLAKATLALGLLTTGVITSEGQAVQAKEKQERVQHLYDIKDLHRYYSSESFEFSNISGKVENYNGSNVVRFNQENQNHQLFLLGKDKEKYKEGIEGKDVFVVKELIDPNGRLSTVGGVTKKNNKSSETNTHLFVNKVYGGNLDASIDSFSINKEEVSLKELDFKIRQHLVKNYGLYKGTTKYGKITINLKDGEKQEIDLGDKLQFERMGDVLNSKDINKIEVTLKQI

Gene
ssl7
Protein
Staphylococcal superantigen-like 7
Organism
Staphylococcus aureus (strain Newman)
Length
231 amino acids
Function
Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5 (PubMed:23797068). Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration (By similarity).
Similarity
Belongs to the staphylococcal/streptococcal toxin family.
Mass
26.168 kDa
Sequence
MKLKTLAKATLALGLLTTGVITSEGQAVQAKEKQERVQHLYDIKDLHRYYSSESFEFSNISGKVENYNGSNVVRFNQENQNHQLFLLGKDKEKYKEGIEGKDVFVVKELIDPNGRLSTVGGVTKKNNKSSETNTHLFVNKVYGGNLDASIDSFSINKEEVSLKELDFKIRQHLVKNYGLYKGTTKYGKITINLKDGEKQEIDLGDKLQFERMGDVLNSKDINKIEVTLKQI