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SPT4

Gene
spt4
Protein
Transcription elongation factor spt4
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
156 amino acids
Function
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
17.463 kDa
Sequence
MSSSYYVTPSQQRTLRACMVCSLVQLHSKFMRDGCPNCDNVLGLRGNNDAIQECTSQVFEGLITLRDPSTSWVARWQRLEGYVAGTYAVKVTGSLPDDVITNLEDSGVRYIPYVYLPGSCVSGDTDRLVGGMAVRWRRRPEVLELSSEVEVQFAWI

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
123 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
13.919 kDa
Sequence
MSSSNYVTTGQARNLRACMICSIVMTSQRFQNEGCPNCEEFLHLQHSPDQIESCTSQVFEGVITLANPTKSWIAKYQRLDSYVPGMYAIKVSGQLPDDVRSTLEDEYRIQYIPRDGTEVENDA

Gene
spt4
Protein
Transcription elongation factor SPT4
Organism
Drosophila melanogaster
Length
116 amino acids
Function
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF may also promote transcriptional elongation within coding regions. DSIF is required for the transcriptional induction of heat shock response genes and regulation of genes which control anterior-posterior patterning during embryonic development (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
13.332 kDa
Sequence
MAFDAIPKDLRGLRACLVCSLVKSFDQFETDGCENCEEFLRMKNNKDNVYDHTSNNFDGIIALTTPTDSWVAKWQRLSRFTRGIYAISVSGTLPQSTLRDMKNRGIVYKSRDRSQR

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
113 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
12.634 kDa
Sequence
MPPKSGRAELRACLVCSILQSTNDFLTQGCPNCEDILEMRGSAERVAECTSLLYDGMIAMIEPSESWVARWQRIDKRMRGIYAVRVTGRAPQDVIDAIEARGGVYRPRDAVED

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
113 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
12.634 kDa
Sequence
MPPKSGRAELRACLVCSILQSTNDFLTQGCPNCEDILEMRGSAERVAECTSLLYDGMIAMIEPSESWVARWQRIDKRMRGIYAVRVTGRAPQDVIDAIEARGGVYRPRDAVED

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
112 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
12.538 kDa
Sequence
MSSRSERACMLCGIIQPMKSFIDYGCPNCESLLHYQYNDNKQVQDCTSPSFEGLVALGEDNKGSWVARWLRIDSFTAGLYAVKVNGKLPPSIIAELEEQNVIYRPRDGSAED

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
111 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
12.178 kDa
Sequence
MSARSERACMLCGIIQPFRKFVDFGCPNCESVLHFQDNEDNQVQDCTSPSFEGLVALGDETKSPGGERLRIDSFVAGLYAVKINGKLPPHIIGDLADQNISYRPRDGSAED

Gene
spt4
Protein
Transcription elongation factor spt4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
105 amino acids
Function
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
11.879 kDa
Sequence
MDKLNRTRSRACLICGIVLPHSVFANKGCPNDGVDDVETFTSPVFEGIMAMMSPTESWVARWQRIDTFTPGIYATRVQGVLNEDVVESLRRRGINYRPRNGTSWD

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
102 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
11.224 kDa
Sequence
MSTDRACMLCGLVQSTAEFNRNGCPNCQSIFEEAGVSAVECTSPSFEGLVGMCKPSRSWVARWMSIDSYIPGMYAVKIDGRLPIEVTELLPHYKPRDGSQVD

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
102 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. The complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. Structural and functional component of the centromeric and heterochromatic loci linking chromatin structure with kinetochore function and gene silencing.
Similarity
Belongs to the SPT4 family.
Mass
11.158 kDa
Sequence
MSSERACMLCGIVQTTNEFNRDGCPNCQGIFEEAGVSTMECTSPSFEGLVGMCKPTKSWVAKWLSVDHSIAGMYAIKVDGRLPAEVVELLPHYKPRDGSQVE

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
102 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
11.206 kDa
Sequence
MSSDRACMLCGIVQTTNEFTRDGCPNCQGIFEEASVSAIECTSPSFEGLVGMCKPTKSWVAKWISVEQYVPGMYAIKVDGRLPVEVVDLLPHYKPRDGSQVD

Gene
SPT4
Protein
Transcription elongation factor SPT4
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
102 amino acids
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT4 family.
Mass
11.084 kDa
Sequence
MSSERACMLCGIVQTTNEFGRVGCPNCQGIFEEAGVSTMECTSPSFEGLVGMCKPTKSWVAKWLSVDANIPGMYAVKVDGRLPPEVVELLPHYKPRDGSQVE

Gene
spt4
Protein
Transcription elongation factor Spt4
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
61 amino acids
Function
Stimulates transcription elongation.
Similarity
Belongs to the archaeal Spt4 family.
Mass
6.953 kDa
Sequence
MSEKACRHCHYITSEDRCPVCGSRDLSEEWFDLVIIVDVENSEIAKKIGAKVPGKYAIRVR

Gene
spt4
Protein
Transcription elongation factor Spt4
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
59 amino acids
Function
Stimulates transcription elongation.
Similarity
Belongs to the archaeal Spt4 family.
Mass
6.578 kDa
Sequence
MRACLKCKYLTNDEICPICHSPTSENWIGLLIVINPEKSEIAKKAGIDIKGKYALSVKE