Sorl1

Sortilin-related receptor

2215 amino acids

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. Involved in APP trafficking to and from the Golgi apparatus (By similarity). It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta (By similarity). Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

Belongs to the VPS10-related sortilin family. SORL1 subfamily.

247.086 kDa

MATRSSRRESRLPFLFALVALLPRGALGGGWTQRLHGGPAPLPQDRGFFVVQGDPRDLRLGTHGDAPGASPAARKPLRTRRSAALQPQPIQVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFSKISEKLNFGVGNNSEAVISQFYHSPADNKRYIFVDAYAQYLWITFDFCSTIHGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNAIYIERHEPFGFSTVLRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLPGSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADAAEDQVFVCVSHSNNSTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAMRKSIYRYDLASGATEQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVDSQWIYWTDAYLDCIERITFSGQQRSVILDSLPHPYAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILASQLTGLMDMKVFYKGKNAGSNACVPQPCSLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDCPQGYQRKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTVCDADTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCHNGHCIPQRWACDGDADCQDGSDEDPVSCEKKCNGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIVQCRDGSDEDAAFAGCSQDPEFHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFHCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHVLPSPTPGPSTCLPNYFHCSSGACVMGTWVCDGYRDCADGSDEEACPSLANSTAASTPTQFGQCDRFEFECHQPKKCIPNWKRCDGHQDCQDGQDEANCPTHSTLTCTSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQVHCLNKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEGVILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTIKGKVIQAPNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHKQEKKTLSFRGGSALSHRVSNLTAHTSYEISAWAKTDLGDSPLAFEHILTRGSSPPAPSLKAKAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSVTTSLHNKTVIVSKDEQYLFLVRVLIPYQGPSSDYVVVKMIPDSRLPPRHLHAVHIGKTSALIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKQFNETRGYEIHMSDSAVNLTAYLGNTTDNFFKVSNLKMGHNYTFTVQARCLFGSQICGEPAVLLYDELSSGADAAVIQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFSAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA

SORL1

Sortilin-related receptor

2214 amino acids

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

Belongs to the VPS10-related sortilin family. SORL1 subfamily.

248.426 kDa

MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA

SORL1

Sortilin-related receptor

2213 amino acids

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction (By similarity). Involved in APP trafficking to and from the Golgi apparatus (By similarity). It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta (By similarity). Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

Belongs to the VPS10-related sortilin family. SORL1 subfamily.

247.766 kDa

MATRSSRRESRLPFLFTLVALLPPGALCEVWTRTLHGGRAPLPQERGFRVVQGDPRELRLWERGDARGASRADEKPLRRRRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPRSSDVYVSYDYGKSFNKISEKLNFGAGNNTEAVVAQFYHSPADNKRYIFADAYAQYLWITFDFCNTIHGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSPLQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYTPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSEGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKAFTFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFRMSEDLALEVCVPDPGFSGKSSPPVPCPVGSTYRRSRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYATRKSIHRYDLASGTTEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSDLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTVVNSSVLDRPRALVLVPQEGIMFWTDWGDLKPGIYRSNMDGSAAYRLVSEDVKWPNGISVDDQWIYWTDAYLDCIERITFSGQQRSVILDRLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILASQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPRANNSKSCRCPDGVASSVLPSGDLMCDCPKGYELKNNTCVKEEDTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDEKNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDERHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDADCQDGSDEDPANCEKKCNGFRCPNGTCIPSTKHCDGLHDCSDGSDEQHCEPLCTRFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDPAFAGCSRDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCDNGHCIPNRWKCDRENDCGDWSDEKDCGDSHVLPSTTPAPSTCLPNYYRCGGGACVIDTWVCDGYRDCADGSDEEACPSLPNVTATSSPSQPGRCDRFEFECHQPKKCIPNWRRCDGHQDCQDGQDEANCPTHSTLTCMSWEFKCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGNVTLTWMRPKKMPSAACVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKVHNTNDFVTLRTPEGLPDAPQNLQLSLHGEEEGVIVGHWSPPTHTHGLIREYIVEYSRSGSKVWTSERAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTVKGKAIPPPNIHIDNYDENSLSFTLTVDGNIKVNGYVVNLFWAFDTHKQEKKTMNFQGSSVSHKVGNLTAQTAYEISAWAKTDLGDSPLSFEHVTTRGVRPPAPSLKARAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPSSLTTPLHNATVLVGKDEQYLFLVRVVMPYQGPSSDYVVVKMIPDSRLPPRHLHAVHTGKTSAVIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVKSRNSTVEYTLSKLEPGGKYHVIVQLGNMSKDASVKITTVSLSAPDALKIITENDHVLLFWKSLALKEKYFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLLGSQICGEPAVLLYDELGSGGDASAMQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA

SORL1

Sortilin-related receptor

1592 amino acids

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Both estrogen status and cholesterol levels lack regulatory effects on this receptor.

Belongs to the VPS10-related sortilin family. SORL1 subfamily.

178.411 kDa

single

GWVSLNDSHNQMVVHWAGEKSNVIVALARDSLSLLGPKNSDVYISYDYGKSFKKISERFSFGDGNSSAVAIAQFYHSPANNQRYIFVDAFVPYLWITTDFCKSIQGFSIPFRAADLLLHSRNPNLVLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGVEPYDKPNTVYIERHEPSGTSTVIRSTDFFQSRENKEVILEDVDDFQLRDKYLFATKAVRLLGSLQPSSVQLWVSFNRKPMRVAQFVTKHPIKEYYIADASEDQVFVCVSHDDNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGVRGVYIATLLNGSFSEENMRSVITFDKGGTWEPLQPPAETRYGEKTHCELSQGCSLHLAQRLSQLLNFQLRRMPILSKESAPGLIIATGSIGKSMAKKTNVYISSSAGARWREALSGPHYYTWGDHGGILVAIAQGTETDQLKYSTNEGETWKSFTFSEKPVFVYGLLTEPGEKSTIFTIFGSYKENGHSWLILQVNTSDVLGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVMVSNCSCTREDFECDFGFKLSEDLSLEVCVPDPEFAGKPYDPPVPCPVGSTYRRTRGYRKISGDTCMGGDIESRLEGEMLPCPLAEENEFILYATRYSIHRYDLASGLSQELPLAGLRGAVALDFDYEHNCLYWADVTLDIIQRLCLNGSSGQEIIISTGLETVEALAFEPLSQLLYWVNAGIPKIEVANPDGDLRLTVLNSSVLERPRALALVPREGLMFWTDWGDSRPGIYRSDMDGSLAACIVSEGVRWPNGISVDDHWIYWTEAYMDRIERVDFNGLQRSVILDSLPHPYAIAVFKNEIYWNDWSQLSIFRASKNSGSRMETLVGRLYGIMDMKIFYRGKTTGQNACIAHPCSLLCLPKSNNGRSCKCPEGVSSTVLPSGEVKCDCPHGYSMKNNTCVKEENTCLPNQYRCFNGNCINSIWQCDNNNDCGDMSDEKNCPTTVCDAETQFRCRESGTCIPLSYKCDLEDDCGDNSDESHCEAHQCRKDEFSCSSGMCIRLSWRCDDDNDCRDWSDEANCTMFRTCEASSFQCLNGHCIPQRWACDGDADCQDGSDEDPTICEKKCNGFQCPNGTCISTSKHCNGITDCADASDEQDCEIPLCTRYMDFVCKNRQQCLSHSMVCDGDIQCEDGSDEDANYAGCAQEPEFHRTCDQFSFQCANGVCISLVWKCDGMDDCGDYSDEASCENPTDAPTCSRYYQFQCGNGHCIPNQWKCDGENDCGDWSDEKECEGSPLLPITTAVPPTCLPNHFRCGSGACITNSWVCDGYRDCADGSDEDACPTSHPNVTSSPPAPRGRCSRTEFECQQLHKCIPNWKRCDGRRDCQDGTDERSCPTHSSLSCPQGYRCEDGEACLLATERCDGYLDCSDGSDERNCTDDTIVYKVQNLQWTADFSGAITLTWARPKRMSSTSCVYNVYYRMVGESIWKVLETHSNKTSSVLKVLKPDCTYQVKVQVQCLSRVYNTNDFITLRVPEGLPDAPFNLQLALKKEAEGVVLCSWSAPVNAHGLIREP