Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Both estrogen status and cholesterol levels lack regulatory effects on this receptor.

Belongs to the VPS10-related sortilin family. SORL1 subfamily.

single

1592 amino acids

GWVSLNDSHNQMVVHWAGEKSNVIVALARDSLSLLGPKNSDVYISYDYGKSFKKISERFSFGDGNSSAVAIAQFYHSPANNQRYIFVDAFVPYLWITTDFCKSIQGFSIPFRAADLLLHSRNPNLVLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGVEPYDKPNTVYIERHEPSGTSTVIRSTDFFQSRENKEVILEDVDDFQLRDKYLFATKAVRLLGSLQPSSVQLWVSFNRKPMRVAQFVTKHPIKEYYIADASEDQVFVCVSHDDNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGVRGVYIATLLNGSFSEENMRSVITFDKGGTWEPLQPPAETRYGEKTHCELSQGCSLHLAQRLSQLLNFQLRRMPILSKESAPGLIIATGSIGKSMAKKTNVYISSSAGARWREALSGPHYYTWGDHGGILVAIAQGTETDQLKYSTNEGETWKSFTFSEKPVFVYGLLTEPGEKSTIFTIFGSYKENGHSWLILQVNTSDVLGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVMVSNCSCTREDFECDFGFKLSEDLSLEVCVPDPEFAGKPYDPPVPCPVGSTYRRTRGYRKISGDTCMGGDIESRLEGEMLPCPLAEENEFILYATRYSIHRYDLASGLSQELPLAGLRGAVALDFDYEHNCLYWADVTLDIIQRLCLNGSSGQEIIISTGLETVEALAFEPLSQLLYWVNAGIPKIEVANPDGDLRLTVLNSSVLERPRALALVPREGLMFWTDWGDSRPGIYRSDMDGSLAACIVSEGVRWPNGISVDDHWIYWTEAYMDRIERVDFNGLQRSVILDSLPHPYAIAVFKNEIYWNDWSQLSIFRASKNSGSRMETLVGRLYGIMDMKIFYRGKTTGQNACIAHPCSLLCLPKSNNGRSCKCPEGVSSTVLPSGEVKCDCPHGYSMKNNTCVKEENTCLPNQYRCFNGNCINSIWQCDNNNDCGDMSDEKNCPTTVCDAETQFRCRESGTCIPLSYKCDLEDDCGDNSDESHCEAHQCRKDEFSCSSGMCIRLSWRCDDDNDCRDWSDEANCTMFRTCEASSFQCLNGHCIPQRWACDGDADCQDGSDEDPTICEKKCNGFQCPNGTCISTSKHCNGITDCADASDEQDCEIPLCTRYMDFVCKNRQQCLSHSMVCDGDIQCEDGSDEDANYAGCAQEPEFHRTCDQFSFQCANGVCISLVWKCDGMDDCGDYSDEASCENPTDAPTCSRYYQFQCGNGHCIPNQWKCDGENDCGDWSDEKECEGSPLLPITTAVPPTCLPNHFRCGSGACITNSWVCDGYRDCADGSDEDACPTSHPNVTSSPPAPRGRCSRTEFECQQLHKCIPNWKRCDGRRDCQDGTDERSCPTHSSLSCPQGYRCEDGEACLLATERCDGYLDCSDGSDERNCTDDTIVYKVQNLQWTADFSGAITLTWARPKRMSSTSCVYNVYYRMVGESIWKVLETHSNKTSSVLKVLKPDCTYQVKVQVQCLSRVYNTNDFITLRVPEGLPDAPFNLQLALKKEAEGVVLCSWSAPVNAHGLIREP

178.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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