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SNX33

Gene
SNX33
Protein
Sorting nexin-33
Organism
Homo sapiens
Length
574 amino acids
Function
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.
Similarity
Belongs to the sorting nexin family.
Mass
65.265 kDa
Sequence
MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVRSGISTNHADYSSSPAGSPGAQVSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDWDDGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVGRNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQTKFKGIKSYISYKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSAFQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEKTLRMYDNL

Gene
Snx33
Protein
Sorting nexin-33
Organism
Mus musculus
Length
574 amino acids
Function
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
65.315 kDa
Sequence
MALKGRALYDFHSENKEEISIQQDEELVIFSETSLDGWLQGQNSRGETGLFPASYVEIVRPGISTNHVDYSNSPAGSLGTQGSLYSSPSMASPARSGGGSGFLSNPGSFEDDDDDDWDDWDDGCTVVEEPLAGGLGTNGHPPLNLSYPGAYPNQHMAFRPKAPLERQDSLASAKRGSVVGRNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSIEDPTKQTKFKGIKSYISYKLTPTHAGSPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSNVAAELVRKHVGGFRKEFQKLGSAFQAISHAFQMDPPFRSDALNNAISHTGRTYETVGEMFAEQPKHDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMAQEEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQSYLRQQILFYQRVGQQLEKTLHMYDHL

Gene
snx33
Protein
Sorting nexin-33
Organism
Xenopus laevis
Length
550 amino acids
Function
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking, both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
63.323 kDa
Sequence
MALKARALYSFQGENKEEINLMENEELQLLSDVSLDGWLQGTNSRGQTGLFPASYVEIQSSRSGSVQVDYSGNAREYTDPPHQGSYDDDDEEDDDDWDDWDDGQTVVDEPSGSNGVSRSELQHHHHYSRPEYSHRPRPALERQDSIASGKRGSVVGRNLNRFSSFVRSGVEAFVLGDVPQFGGVAESHAIEMAPKGPQWKANPRPFNCSVEEPTKQTKFKGIKSYISYRLTPDHSNSPVYRRYKHFDWLYNRLLHKFTVISLPHLPEKQATGRFEEDFIQKRKRRLVLWMDHMTSHPVLSQYDGFQHFLGCQDEKQWKAGKRRAERDELVGASFLLTLQLPTEHQDLQDVEERVDVFKAFSKKMDESVLQLSSVVSELARKHLGGFRKEFQKLGAAFQGLSHSFQLDPPYSSEPLVGAISHTGRTYEAVGEMFAEQPKNDQFRFLDTLSLYQGLLSNFPDIIHLQKGAFAKVKDSQRMSDEGRMEQDEADGVRKRCRVVGFALQAEINHFHQRRLLDFKQAIQHYLKEQIIFYRRVSQELEKTLHLYDEL

Gene
snx33
Protein
Sorting nexin-33
Organism
Xenopus tropicalis
Length
549 amino acids
Function
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking, both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
63.298 kDa
Sequence
MALKARALYSFQGENKEEINILENEELHLFSDVSLDGWLQGTNSRGQTGLFPASYVEILRPRSGSVQVDYSGHTQGYTDSPHQGSYDDDEEDDDDWDDWDDGQTVVDEPSGSNGVSRSQLQHHHHYPRPEYTHRPRPALERQDSIASGKRGSVVGRNLNRFSSFVRSGVEAFVLGDVPQFGGVSESHAIEMGPKGPQWKANPRPFSCSVEEPTKQTKFKGIKSYISYRLTPDPCNSPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIQKRKRRLVLWMDHMTSHPVLSQYDGFQHFLSCQDEKQWKAGKRRAERDELVGASFLLTLQLPTEHQDLQDVEERVDVFKAFSKKMDENVLQLSSVVSELARKHLGGFRKEFQRLGAALQGLSHSFQLDPPYSSEPLVGAISHTGRTYEAVGEMFAEQPKNDQFRFLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMEQDEADGIRKRCRVVGFALQAEINHFHQRRLQDFKQAIQHYLKEQILFYRRVSQELEKTLHMYDDL