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RNF152

Gene
RNF152
Protein
E3 ubiquitin-protein ligase RNF152
Organism
Ailuropoda melanoleuca
Length
203 amino acids
Function
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.
Similarity
Belongs to the RNF152 family.
Mass
22.28 kDa
Sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVAQLPDDPEVLAVIAIPHASEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTVPAEQRPLQGGAPQEAVEEEPDRRGVAKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG

Gene
RNF152
Protein
E3 ubiquitin-protein ligase RNF152
Organism
Gallus gallus
Length
203 amino acids
Function
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.
Similarity
Belongs to the RNF152 family.
Mass
22.239 kDa
Sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDLRCPWCRGITKLPPGYSVSQLPDDPEVIAVIAIPHTSEHTPVFIKLPSNGCYMLPLPLSKERAMLPGDIGCRLLPGSQQKSLAVVTIPAEQQPLQGGLPAEAGAEEPDRRGVVKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG

Gene
RNF152
Protein
E3 ubiquitin-protein ligase RNF152
Organism
Homo sapiens
Length
203 amino acids
Function
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).
Similarity
Belongs to the RNF152 family.
Mass
22.357 kDa
Sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG

Gene
Rnf152
Protein
E3 ubiquitin-protein ligase RNF152
Organism
Mus musculus
Length
203 amino acids
Function
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (By similarity).
Similarity
Belongs to the RNF152 family.
Mass
22.353 kDa
Sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERTLLPGDMGCRLLPGSQQKSLTVVTIPAEQQPLQGGAPPEAVEEEPDRRGVVKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG

Gene
Rnf152
Protein
E3 ubiquitin-protein ligase RNF152
Organism
Rattus norvegicus
Length
203 amino acids
Function
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.
Similarity
Belongs to the RNF152 family.
Mass
22.356 kDa
Sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERTLLPGDMGCRLLPGSQQKSLTVVTIPAEQQPLQGGAPQEAVEEEPDRRGVAKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG

Gene
rnf152
Protein
E3 ubiquitin-protein ligase rnf152
Organism
Danio rerio
Length
198 amino acids
Function
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.
Similarity
Belongs to the RNF152 family.
Mass
21.736 kDa
Sequence
MDSLSQSSRLECQICFNYFSQRRLPKLLHCQHTCCSVCLSQMRLSQREIRCPWCRCVTQIPIGLSVSHLPDDPEVLSVISVSQSSEHTPIFIHLPNNGCYLLPVSLDTDGTPLPGQPTCHVGPKSIGVFDVSDGQNHVLGHDGLGDGMEEEEVVVVKTTAWTGVCTVLLVAFILIFLLGIVLHNMSCVSKRFTIISCG