Description
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.
Family
Belongs to the RNF152 family.
Sequence
MDSLSQSSRLECQICFNYFSQRRLPKLLHCQHTCCSVCLSQMRLSQREIRCPWCRCVTQIPIGLSVSHLPDDPEVLSVISVSQSSEHTPIFIHLPNNGCYLLPVSLDTDGTPLPGQPTCHVGPKSIGVFDVSDGQNHVLGHDGLGDGMEEEEVVVVKTTAWTGVCTVLLVAFILIFLLGIVLHNMSCVSKRFTIISCG
Simulated SDS-PAGE

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
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Protein synthesis service