RIR1

Ribonucleoside-diphosphate reductase large subunit-like protein

1174 amino acids

Provides optimal viral replication conditions by promoting host cell survival and avoiding the host inflammatory response linked to NF-kappa-B activation. Blocks RIPK1 ubiquitination, thereby preventing NF-kappa-B activation and virally induced inflammatory response. Targets host RIPK3 to prevent the formation of necroptotic RIPK1-RIPK3 complexes leading to induced cell necroptosis. Also inhibits ZBP1-induced NF-kappa-B activation. Does not have ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

Belongs to the ribonucleoside diphosphate reductase large chain family.

125.215 kDa

MDRQPKVYSDPDNGFFFLDVPMPDDGQGGQQTATTAAGGAFGVGGGHSVPYVRIMNGVSGIQIGNHNAMSIASCWSPSYTDRRRRSYPKTATNAAADRVAAAVSAANAAVNAAAAAAAAGGGGGANLLAAAVTCANQRGCCGGNGGHSLPPTRMPKTNATAAAAPAVAGASNAKSDNNHANATSGAGSAAATPAATTPAATAVENRRPSPSPSTASTAPCDEGSSPRHHRPSHVSVGTQATPSTPIPIPAPRCSTGQQQQQPQAKKLKPAKADPLLYAATMPPPASVTTAAAAAVAPESESSPAASAPPAAAAMATGGDDEDQSSFSFVSDDVLGEFEDLRIAGLPVRDEMRPPTPTMTVIPVSRPFRAGRDSGRDALFDDAVESVRCYCHGILGNSRFCALVNEKCSEPAKERMARIRRYAADVTRCGPLALYTAIVSSANRLIQTDPSCDLDLAECYVETASKRNAVPLSAFYRDCDRLRDAVAAFFKTYGMVVDAMAQRITERVGPALGRGLYSTVVMMDRCGNSFQGREETPISVFARVAAALAVECEVDGGVSYKILSSKPVDAAQAFDAFLSALCSFAIIPSPRVLAYAGFGGSNPIFDAVSYRAQFYSAESTINGTLHDICDMVTNGLSVSVSAADLGGDIVASLHILGQQCKALRPYARFKTVLRIYFDIWSVDALKIFSFILDVGREYEGLMAFAVNTPRIFWDRYLDSSGDKMWLMFARREAAALCGLDLKSFRNVYEKMERDGRSAITVSPWWAVCQLDACVARGNTAVVFPHNVKSMIPENIGRPAVCGPGVSVVSGGFVGCTPIHELCINLENCVLEGAAVESSVDVVLGLGCRFSFKALESLVRDAVVLGNLLIDMTVRTNAYGAGKLLTLYRDLHIGVVGFHAVMNRLGQKFADMESYDLNQRIAEFIYYTAVRASVDLCMAGADPFPKFPKSLYAAGRFYPDLFDDDERGPRRMTKEFLEKLREDVVKHGIRNASFITGCSADEAANLAGTTPGFWPRRDNVFLEQTPLMMTPTKDQMLDECVRSVKIEPHRLHEEDLSCLGENRPVELPVLNSRLRQISKESATVAVRRGRSAPFYDDSDDEDEVACSETGWTVSTDAVIKMCVDRQPFVDHAQSLPVAIGFGGSSVELARHLRRGNALGLSVGVYKCSMPPSVNYR

RIR1

Ribonucleoside-diphosphate reductase large subunit

1144 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

125.093 kDa

MANRPAASALAGARSPSERQEPREPEVAPPGGDHVFCRKVSGVMVLSSDPPGPAAYRISDSSFVQCGSNCSMIIDGDVARGHLRDLEGATSTGAFVAISNVAAGGDGRTAVVALGGTSGPSATTSVGTQTSGEFLHGNPRTPEPQGPQAVPPPPPPPFPWGHECCARRDARGGAEKDVGAAESWSDGPSSDSETEDSDSSDEDTGSGSETLSRSSSIWAAGATDDDDSDSDSRSDDSVQPDVVVRRRWSDGPAPVAFPKPRRPGDSPGNPGLGAGTGPGSATDPRASADSDSAAHAAAPQADVAPVLDSQPTVGTDPGYPVPLELTPENAEAVARFLGDAVDREPALMLEYFCRCAREESKRVPPRTFGSAPRLTEDDFGLLNYALAEMRRLCLDLPPVPPNAYTPYHLREYATRLVNGFKPLVRRSARLYRILGILVHLRIRTREASFEEWMRSKEVDLDFGLTERLREHEAQLMILAQALNPYDCLIHSTPNTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGRQGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNQATLRAITGNVSAILARNGGIGLCMQAFNDASPGTASIMPALKVLDSLVAAHNKQSTRPTGACVYLEPWHSDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWSLFDRDTSMSLADFHGEEFEKLYEHLEAMGFGETIPIQDLAYAIVRSAATTGSPFIMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPSSKRSSGVCNLGSVNLARCVSRRTFDFGMLRDAVQACVLMVNIMIDSTLQPTPQCARGHDNLRSMGIGMQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLAAMKTSNALCVRGARPFSHFKRSMYRAGRFHWERFSNASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFGGKRLLDAMDGLEAKQWSVAQALPCLDPAHPLRRFKTAFDYDQELLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFAGDDNIVCTSCAL

RIR1

Ribonucleoside-diphosphate reductase large subunit

1142 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). The N-terminal region confers antiapoptotic activity in differentiated cells such as neurons and is important for viral reactivation to increase neural survivability.

Belongs to the ribonucleoside diphosphate reductase large chain family.

124.923 kDa

MANRPAASALAGARSPSERQEPREPEVAPPGGDHVFCRKVSGVMVLSSDPPGPAAYRISDSSFVQCGSNCSMIIDGDVARGHLRDLEGATSTGAFVAISNVAAGGDGRTAVVALGGTSGPSATTSVGTQTSGEFLHGNPRTPEPQGPQAVPPPPPPPFPWGHECCARRDARGGAEKDVGAAESWSDGPSSDSETEDSDSSDEDTGSETLSRSSSIWAAGATDDDDSDSDSRSDDSVQPDVVVRRRWSDGPAPVAFPKPRRPGDSPGNPGLGAGTGPGSATDPRASADSDSAAHAAAPQADVAPVLDSQPTVGTDPGYPVPLELTPENAEAVARFLGDAVDREPALMLEYFCRCAREESKRVPPRTFGSAPRLTEDDFGLLNYALAEMRRLCLDLPPVPPNAYTPYHLREYATRLVNGFKPLVRRSARLYRILGVLVHLRIRTREASFEEWMRSKEVDLDFGLTERLREHEAQLMILAQALNPYDCLIHSTPNTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGRQGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNQATLRAITGNVSAILARNGGIGLCMQAFNDASPGTASIMPALKVLDSLVAAHNKQSTRPTGACVYLEPWHSDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWSLFDRDTSMSLADFHGEEFEKLYEHLEAMGFGETIPIQDLAYAIVRSAATTGSPFIMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLAAMKTSNALCVRGARPFSHFKRSMYRAGRFHWERFSNASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFGGKRLLDAMDGLEAKQWSVAQALPCLDPAHPLRRFKTAFDYDQELLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFAGDDNIVCTSCAL

RIR1

Ribonucleoside-diphosphate reductase large subunit

1137 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

124.051 kDa

MASRPAASSPVEARAPVGGQEAGGPSAATQGEAAGAPLAHGHHVYCQRVNGVMVLSDKTPGSASYRISDNNFVQCGSNCTMIIDGDVVRGRPQDPGAAASPAPFVAVTNIGAGSDGGTAVVAFGGTPRRSAGTSTGTQTADVPTEALGGPPPPPRFTLGGGCCSCRDTRRRSAVFGGEGDPVGPAEFVSDDRSSDSDSDDSEDTDSETLSHASSDVSGGATYDDALDSDSSSDDSLQIDGPVCRPWSNDTAPLDVCPGTPGPGADAGGPSAVDPHAPTPEAGAGLAADPAVARDDAEGLSDPRPRLGTGTAYPVPLELTPENAEAVARFLGDAVNREPALMLEYFCRCAREETKRVPPRTFGSPPRLTEDDFGLLNYALVEMQRLCLDVPPVPPNAYMPYYLREYVTRLVNGFKPLVSRSARLYRILGVLVHLRIRTREASFEEWLRSKEVALDFGLTERLREHEAQLVILAQALDHYDCLIHSTPHTLVERGLQSALKYEEFYLKRFGGHYMESVFQMYTRIAGFLACRATRGMRHIALGREGSWWEMFKFFFHRLYDHQIVPSTPAMLNLGTRNYYTSSCYLVNPQATTNKATLRAITSNVSAILARNGGIGLCVQAFNDSGPGTASVMPALKVLDSLVAAHNKESARPTGACVYLEPWHTDVRAVLRMKGVLAGEEAQRCDNIFSALWMPDLFFKRLIRHLDGEKNVTWTLFDRDTSMSLADFHGEEFEKLYQHLEVMGFGEQIPIQELAYGIVRSAATTGSPFVMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVSRQTFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDLESAEFQDLNKHIAEVMLLSAMKTSNALCVRGARPFNHFKRSMYRAGRFHWERFPDARPRYEGEWEMLRQSMMKHGLRNSQFVALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLRPNTLLLKELERTFSGKRLLEVMDSLDAKQWSVAQALPCLEPTHPLRRFKTAFDYDQKLLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVHAYKRGLKTGMYYCKVRKATNSGVFGGDDNIVCMSCAL

RIR1

Ribonucleoside-diphosphate reductase large subunit-like protein

906 amino acids

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

Belongs to the ribonucleoside diphosphate reductase large chain family.

101.668 kDa

MNPADADEEQRVSSVPAHRCRPGRIPSRSAETETEESSAEVAADTIGGDDSELEEGPLPGGDKEASAGNTNVSSGVACVAGFTSGGGVVSWRPESPSPDGTPSVLSLTRDSGPAVPSRGGRVSSGLSTFNPAGATRMELDSVEEEDDFGASLCKVSPPIQATRMLMGKKCHCHGYWGKFRFCGVQEPARELPSDRNALWREMDTVSRHSAGLGSFRLFQLIMRHGPCLIRHSPRCDLLLGRFYFKANWARESRTPLCYASELCDESVRRFVLRHMEDLPKLAEETARFVELAGCWGLYAAILCLDKVCRQLHGQDESPGGVFLRIAVALTAAIENSRHSRIYRFHLDARFEGEVLESVLKRCRDGQLSLSTFTMSTVGFDRVPQYDFLISADPFSRDASWAAMCKWMSTLSCGVSVSVNVTRLNADVNSVIRCLGGYCDLIREKEVHRPVVRVFVDMWDVAAIRVINFILKESTSELTGVCYAFNVPSVLMKRYRAREQRYSLFGRPVSRRLSDLGQESAFEKEYSRCEQSCPKVVVNTDDFLKKMLLCALKGRASVVFVHHVVKYSIMADSVCLPPCLSPDMASCHFGECDMPVQRLTVNVARCVFARSDEQKLHLPDVVLGNTRRYFDLSVLRELVTEAVVWGNARLDALMSASEWWVESALEKLRPLHIGVAGLHTALMRLGFTYFASWDLIERIFEHMYFAAVRASVDLCKSGLPRCEWFERTIYQEGKFIFELYRLPRLSIASARWEALRADMLEFGLRNCQFLAVGPDDEVAHLWGVTPSVWASRGTVFEEETVWSLCPPNRECYFPTVVRRPLRVPVVNYAWLEQHQEEGKATQCLFQAAPAIQNDVEMAAVNLSVFVDQCVALVFYYDSGMTPDVLLARMLKWYHWRFKVGVYKYCAS

RIR1

Ribonucleoside-diphosphate reductase large subunit-like protein

906 amino acids

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

Belongs to the ribonucleoside diphosphate reductase large chain family.

101.698 kDa

MNPADADEEQRVSSVPAHRCRPGRIPSRSAETETEESSAEVAADTIGGDDSELEEGPLPGGDKEASAGNTNVSSGVACVAGFTSGGGVVSWRPESPSPDGTPSVLSLTRDSGPAVPSRGGRVSSGLSTFNPAGATRMELDSVEEEDDFGASLCKVSPPIQAMRMLMGKKCHCHGYWGKFRFCGVQEPARELPSDRNALWREMDTVSRHSAGLGSFRLFQLIMRHGPCLIRHSPRCDLLLGRFYFKANWARESRTPLCYASELCDESVRRFVLRHMEDLPKLAEETARFVELAGCWGLYAAILCLDKVCRQLHGQDESPGGVFLRIAVALTAAIENSRHSRIYRFHLDARFEGEVLESVLKRCRDGQLSLSTFTMSTVGFDRVPQYDFLISADPFSRDASWAAMCKWMSTLSCGVSVSVNVTRLNADVNSVIRCLGGYCDLIREKEVHRPVVRVFVDMWDVAAIRVINFILKESTSELTGVCYAFNVPSVLMKRYRAREQRYSLFGRPVSRRLSDLGQESAFEKEYSRCEQSCPKVVVNTDDFLKKMLLCALKGRASVVFVHHVVKYSIMADSVCLPPCLSPDMASCHFGECDMPVQRLTVNVARCVFARSDEQKLHLPDVVLGNTRRYFDLSVLRELVTEAVVWGNARLDALMSASEWWVESALEKLRPLHIGVAGLHTALMRLGFTYFASWDLIERIFEHMYFAAVRASVDLCKSGLPRCEWFERTIYQEGKFIFELYRLPRLSIASARWEALRADMLEFGLRNCQFLAVGPDDEVAHLWGVTPSVWASRGTVFEEETVWSLCPPNRECYFPTVVRRPLRVPVVNYAWLEQHQEEGKATQCLFQAAPAIQNDVEMAAVNLSVFVDQCVALVFYYDSGMTPDVLLARMLKWYHWRFKVGVYKYCAS

RIR1

Ribonucleoside-diphosphate reductase large subunit

835 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

91.06 kDa

MPPRAPRPAGAVSPPFPPLAGPPLKARAPRARDSPLTSPCRAHAAMASVVAPAASSSAAAPGADAFLDAACPEDVARALAAELEALRALGHDVGAPAPGASRREAALFITRAVDGLKAFSRVDERVYVACGKLVHLRVRSREADLDAWLASPELALIPAVAAAVRRHRARVEAALRWFWREAYPALYARGLQSALKYEEMYLARLEHGRCEAMDQFFVRLAAAAATATRRPMALVLCGSDAWPEVFDAYFRALATQAIVPATPLMLFAGRARGSLASCYLLNPLPRTTEEAVRAITDEVAPILLRRGGVGLSLQSFNRTPSGDCTRGIMAVLKALDSMTAAINSDSERPTGVCVYVEPWHADVRAVLNMRGMLAADESLRCDNIFSCLWTPDLFFQRYQRHLDGERAVKWTLFDDRASHLASLHGPDFAREYERLERLGLGVESLPIQDMAFLIVRSAVMTGSPFLMMKDACNRHFHTDTRGAALATSNLCTEIVQRATPGENGVCNLASVNLPACLAGGAFDFAALRRAARVAAVFVNAMMRIGNYPTGASVEGVRRSRSLGIGLQGLHTTVLALDMDMADPAARRLNAAIAEELLYGVMDASVELCERGLRPFDGFEHSRYARGVMPFDAYERVSLREPMRWDALRVRIAEHGVYNAQFVALMPTVSSSQVTESSEGFSPTFTNMFSKVTISGELLRPNLPLMETLRRLFPRECARRDAVARLERAQWSVAAAFGELPAGHPLAKFKTAFEYDQELLIDMCADRAPFVDHSQSMSLFLTEPADGKLHASRVMGLLMRAYNLGLKTGMYYCKIRKATNNGVFTGGDLVCTSCHL

RIR1

Ribonucleoside-diphosphate reductase large subunit

826 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

93.031 kDa

MATTSHVEHELLSKLIDELKVKANSDPEADVLAGRLLHRLKAESVTHTVAEYLEVFSDKFYDEEFFQMHRDELETRVSAFAQSPAYERIVSSGYLSALRYYDTYLYVGRSGKQESVQHFYMRLAGFCASTTCLYAGLRAALQRARPEIESDMEVFDYYFEHLTSQTVCCSTPFMRFAGVENSTLASCILTTPDLSSEWDVTQALYRHLGRYLFQRAGVGVGVTGAGQDGKHISLLMRMINSHVEYHNYGCKRPVSVAAYMEPWHSQIFKFLETKLPENHERCPGIFTGLFVPELFFKLFRDTPWSDWYLFDPKDAGDLERLYGEEFEREYYRLVTAGKFCGRVSIKSLMFSIVNCAVKAGSPFILLKEACNAHFWRDLQGEAMNAANLCAEVLQPSRKSVATCNLANICLPRCLVNAPLAVRAQRADTQGDELLLALPRLSVTLPGEGAVGDGFSLARLRDATQCATFVVACSILQGSPTYDSRDMASMGLGVQGLADVFADLGWQYTDPPSRSLNKEIFEHMYFTALCTSSLIGLHTRKIFPGFKQSKYAGGWFHWHDWAGTDLSIPREIWSRLSERIVRDGLFNSQFIALMPTSGCAQVTGCSDAFYPFYANASTKVTNKEEALRPNRSFWRHVRLDDREALNLVGGRVSCLPEALRQRYLRFQTAFDYNQEDLIQMSRDRAPFVDQSQSHSLFLREEDAARASTLANLLVRSYELGLKTIMYYCRIEKAADLGVMECKASAALSVPREEQNERSPAEQMPPRPMEPAQVAGPVDIMSKGPGEGPGGWCVPGGLEVCYKYRQLFSEDDLLETDGFTERACESCQ

RIR1

Ribonucleoside-diphosphate reductase large subunit

826 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

93.031 kDa

MATTSHVEHELLSKLIDELKVKANSDPEADVLAGRLLHRLKAESVTHTVAEYLEVFSDKFYDEEFFQMHRDELETRVSAFAQSPAYERIVSSGYLSALRYYDTYLYVGRSGKQESVQHFYMRLAGFCASTTCLYAGLRAALQRARPEIESDMEVFDYYFEHLTSQTVCCSTPFMRFAGVENSTLASCILTTPDLSSEWDVTQALYRHLGRYLFQRAGVGVGVTGAGQDGKHISLLMRMINSHVEYHNYGCKRPVSVAAYMEPWHSQIFKFLETKLPENHERCPGIFTGLFVPELFFKLFRDTPWSDWYLFDPKDAGDLERLYGEEFEREYYRLVTAGKFCGRVSIKSLMFSIVNCAVKAGSPFILLKEACNAHFWRDLQGEAMNAANLCAEVLQPSRKSVATCNLANICLPRCLVNAPLAVRAQRADTQGDELLLALPRLSVTLPGEGAVGDGFSLARLRDATQCATFVVACSILQGSPTYDSRDMASMGLGVQGLADVFADLGWQYTDPPSRSLNKEIFEHMYFTALCTSSLIGLHTRKIFPGFKQSKYAGGWFHWHDWAGTDLSIPREIWSRLSERIVRDGLFNSQFIALMPTSGCAQVTGCSDAFYPFYANASTKVTNKEEALRPNRSFWRHVRLDDREALNLVGGRVSCLPEALRQRYLRFQTAFDYNQEDLIQMSRDRAPFVDQSQSHSLFLREEDAARASTLANLLVRSYELGLKTIMYYCRIEKAADLGVMECKASAALSVPREEQNERSPAEQMPPRPMEPAQVAGPVDIMSKGPGEGPGGWCVPGGLEVCYKYRQLFSEDDLLETDGFTERACESCQ

RIR1

Ribonucleoside-diphosphate reductase large subunit

826 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

93.102 kDa

MATTNHVEHELLSKLIDELKVKANADPEADVLAGRLLHRLKAESVTHTVAEYLEVFSDKFYDEEFFQMHRDELETRVSAFAQSPAYERIVSSGYLSALRYYDTYLYVGRSGKQESVQHFYMRLAGFCASTTCLYAGLRAALQRARPEIESDMEVFDYYFEHLTSQTVCCSTPFMRFAGVENSTLASCILTTPDLSSEWDVTQALYRHLGRYLFQRAGVGVGVTGAGQDGKHISLLMRMINSHVEYHNYGCKRPVSVAAYMEPWHSQIFKFLETKLPENHERCPGIFTGLFVPELFFKLFRDTPWSDWYLFDPKDAGDLERLYGEEFEREYYRLVTAGKFCGRVSIKSLMFSIVNCAVKAGSPFILLKEACNAHFWRDLQGEAMNAANLCAEVLQPSRKSVATCNLANICLPRCLVNAPLAVRAQRADTQGDELLLALPRLSVTLPGEGAIGDGFSLARLRDATQCATFVVACSILQGSPTYDSRDMASMGLGVQGLADVFADLGWQYTDPPSRSLNKEIFEHMYFTALCTSSLIGLHTRKIFPGFKQSKYAGGWFHWHDWAGTDLSIPREIWSRLSERIVRDGLFNSQFIALMPTSGCAQVTGCSDAFYPFYANASTKVTNKEEALRPNRSFWRHVRLDDREALNLVGGRVSCLPEALRQRYLRFQTAFDYNQEDLIQMSRDRAPFVDQSQSHSLFLREEDAARASTLANLLVRSYELGLKTIMYYCRIEKAADLGVMECKASAALSVPREEQNERSPAEQMLPRPMEPAQVTGPVDIMSKGPGEGPGGWCVPGGLEVCYKYRQLFSEDDLLETDGFTERACESCQ

RIR1

Ribonucleoside-diphosphate reductase large subunit

822 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

92.821 kDa

MDHSDVYEPYTFSGKHHVRMYDFSKLTPMWNKDASTPPRKFADMHIASTVAMELYNIERELLNMGHLSGMETMMVDVRKSPEMIPSTINMRDHITRLVNKMKPICRFDERLYSLCGELVHLRIELREVPLDTWLLSKKLNLKYEVVDNIRRYRAHIEMDMLRFYGSIHPWLKRLGLQSALKYEEYLVELEDGKKESLCQFFVRLAAAAATEASMKKPFMTTLTTGVANWRTTFTTFFLALANQLFVPSTPCMLFLGREGTSTASCYLMDPRTNNTQDTLKAITEDVVPHLLARGGIGISLQHLNGKFGLMHVMKVLDSLVMAANVNESRPTGICVYLEPWHADIMSALNMRGMVAAEESRRCDNVFLALWSCDLLFKRYLRHVNGEKNVIWTLFDSRASILTKLHSEEFEKEYERLESEGLGVASIPIRDMMFAIIKSAASTGSPFILFKDACNRHYITNTQGDAIAGSNLCTEIIQKTDANTNGVCSLASINLARCVRNIDGNRQFDFDALRYAVRLATVFVNAIMEGSDVPTEKSHSGRERNRSMGIGVQGFHTAFLSMGLDLCDERARSLNKLIFEFMLLEAMTVSCEFCERGLPPFADFSNSYYARGRLHFDGWANVELAAVEEWNMLRDRIVSAGLYNAQFIALMPTAASAQVTEVSEGFSPLFSNMFSKVTSTGELLRPNIQLMEELRTIYLDNENQRLATIAALESANWNIQTALGNKPECHSLLKYKTAFDYDQALLIDLCSDRAPFVDQSQSMTLFITETADGTLLASRVMNLLLHAYKAGLKTGMYYCKIRKATNAGVFCGDGELTCSSCVL

RIR1

Ribonucleoside-diphosphate reductase large subunit

811 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

90.42 kDa

MSSATSLVPPAAPDMREHELGECAAFYAAETPQRLFENLLHLENALKARGYDTDSAGAPALGPTTLTMEAIADRITLIINRFKAAVRLDLELYRLLAELVHIRIRTKTVSMQAWIELRGLSRECAEFILERKNFVCELMERFGEVYPTLSRVGLQSARKFESMYLGKLKNGRLESVGQFFLRIAAEAARGVANNDAFAAAVFRDGTRAPDANTVFCLFFMALCRQEIVPPTPVMLFAGTESRSYASCFLLDVRGRHTRDVLTSIAEEIIPVMHSHGGIGLYMDCDSNWDDNSSGMMLALKALDSIIAASNAVSARPSGLCVYVEPWHRDIMKILRCRGVLAGNEETRCDNTFFALWMPDLFMKRFEANGTWTLFDGRAAHLSDLYGEEFEKEYELLERKNVGIATYPARDVMFALIKSAVSTGTPFVMFKHAVNRNYFFDMAGRAMKCSNLCTEIVHMTDDESVGVCNLTSLNLAAFVTRRNALPGTPPIGTFDYSSFRDACAVATVFINALMSLSNLPIKRATTGNERLRSIGIGVQGFHTACLLQGFGLDSVEACRFNGKLFEALALTTFQTSCRICELGMNPFRGFSESKYAKGWLHMDGWPARHLYFDGWDRLRENIKAYGLYNCQLVALMPTASSSQLTEVSEGIHPVFGNIFSKITTTGEDIQLNVALMETIECLYPNKAERRDILERLHKNKWSTRGAFGAALPSQHPLTKFDTAFEADQEHLLRLSADRAPFVDHSQSTTLYVVEEDDGAVRASRVAHLLTTAFKYGLKTGMYYCKVRKATDNGVFLGTDTCRRDDPTCLACQ

RIR1

Ribonucleoside-diphosphate reductase large subunit-like protein

806 amino acids

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

Belongs to the ribonucleoside diphosphate reductase large chain family.

93.07 kDa

MDPNNKVSINKNMGLLRKCLCHDEYNKKRFCYSRFHHKTLLYKQLYEISKILRRLNSGLDMWCLRDAIISALGAMHDAPHVDRLLGQFYLKTNSASEFDSISLILESENILQKELIEFVRDSKVELEKILQAAIHVWRAKFSPGVLAASRFLDEISNSFNGIEENIPTIFLRISVTLASQIKKIEYLQKSFVSHKCPLVEEILILLYKRVCMLPFPCMSNLGLVSEKKSVFDTVFHNVSNFSLEDFLDINSGFFLPAMLNGSYVSVNLTRYHYEAESLMELLLSQLQIVEKDTNKTTGLTIYLEIWHLSLLMWLDFCEILPTTVQVKFCLILPEIFMERLKTENSYWSVFHKALAINLGLYDESDFTSKYLECERTAEHARIKTETLLDNICRCLRRGQMGFIFRKNIHKYSMLPQIASYCLGNSMDVIPFEYGLNTAFRIALNLSYFVENVSEEQKSHTNIDMFHYRDKIFNLKKMRKTVTELVLIGNAVIDYALENRDFLMDGIVNARSLAICVTGLHSALMSMNLPFNSQLGCQLYRIVCENIYYSSVRTSMNCCKKGAEPCSFFQRSKYAQGILHCDLYDNVEYTLPNVLWTNLRSDIKKYGLRNLTFVSGSAMSKEFDLLNCSQSFCPIEGNKILKRSSIKVLHPNPVFHSDLSVYSTELQTLYIPVYNGLFLNRFKNHLEYLSSVNYDVSKVNKNLFSEEEMQEMTIFLNAFDYSVNEMLNMYVGALPFTDHGQANVFFINKTENMRDILVCLYQNGFKTGIYQAVYKNQKCDGVNPSKKFDLLSGFSDGVVMSTMHVFQ

RIR1

Ribonucleoside-diphosphate reductase large subunit-like protein

804 amino acids

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

Belongs to the ribonucleoside diphosphate reductase large chain family.

93.353 kDa

MKRKERRINKDYGYNRKCVCHYEASQKRFCYSQYSCASVLYERVRDIAKIIDRLDSGLDAWCLRDAIISVLRATHCVPRVDRMLGRWYLKTSVFYDFCPDDLILSCPNVIMPNVLNFVKKYRDFIRSVLYKVSVSWKNQYMPGVLAASRFLEEISNSLNGVEESIPCIYLRMCATLTEIVLRIGYLREIYQENPYVMFEELAFSLFTQKWVLPFSCMTNLGLVEKANSTVFDVAIYNTCLYSLVDFTIVNGEHLFPALLNGSNISMNLTRYQQEAKNIFEILLSQIRVVERDTDKTVQLTVYVEVWHVSALMWLDLYEALPQTSRVTFCLIIPGIFMDRYELKRAQWSLFHKNIAFELGKCDEITFSTKYLEFERTTDHAKITMSSFIEKICLCLKGGRMGLIFRKNVYQYSMIPHVPLYCGGDFLDVLPVRDGINTCMRMLLNVVHFLGDEVSDELTEEIDFVRLQCKFFMFNELRRVVRKMVLVANAVIDYAVENKDFLCEGIEDGRSLGICVTGLHSVFMTVGLSYAHPDARRLYRMICEHIYYTCVRTSVDCCMKGAEPCNLFDRSKYALGMLYFDHFDNVECTLPEELWTTLRKDVLMHGVRNIHFTAGTAMQKEFDIINSSESFWPMEDNKILRRSNIKVVIGKDGLNDVTSVYSSELKSLYIPVYNNLLLNRFNKHQQYLKTVGYRVLNVDTNLFTDKELDDLAVFKDGFSYHLNDLIEMYKSGLPFLDQGQANVFYFNDTVSLRLLLPLLYKAGFKVAMYKVLCNSEMYKHLDLSNPLPLIGKCSDGVVMHVKNIL

RIR1

Ribonucleoside-diphosphate reductase large subunit-like protein

804 amino acids

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.

Belongs to the ribonucleoside diphosphate reductase large chain family.

93.283 kDa

MKRKERRINKDFGYNRKCVCHYEASQKRFCYSQYSCASVLYERVRDIAKIMDRLDSGLDAWCLRDAIISVLRATHCVPRVDRMLGRWYLKTSIFYDFCPDDLILSCPNVIMPNVLNFVKKYRDFIRSVLYKVSVSWKNQYMPGVLGASRFLEEISNSLNGVEESIPCIYLRMCATLTEIVLRNGYLREIYQENPYVIFEELAFSLFTQKWVLPFSCMTNLGLVEKANSTVFDVAIYNTCLYSLADFITVNGEHLFPALLNGSNISMNVTRYQQEAKNIFEILLSQIQVVERDTDKTVQLTVYVEVWHVSALTWLDLYQVLPETSRVTFCLIIPGIFMDRYELKRAQWSLFHKNIAFELGKCDEVTFSTKYLEFERTTDHAKITMASFVEKICRCLKRGRMGLIFRKNVYQYSMIPHVPLYCGGDFLDVLPVRDGINTCLRMLLNVVHFLGDEVSDELTEEIDFVRLQCKFFMFNELRRVVRKMVLVANAVIDYAVDNKDFLREGIVDGRSLGICITGLHSVFMTVGLSYAHPDACRLYRMMCEHIYYTCVRTSVDCCMKGAEPCNLFDRSKYALGMLYFDQFDNVECTLPEELWTTLRKDVLMHGVRNIHFTAGTAMQKEFDIINSSESFWPMEDNKILRRSNIKVVIGKDGLNDVTSVYSSELKSLYIPVYNNLLLNRFNKHQQYLKTVGYRVLNVDTNLFTDKELDDLAVFKDGFSYPLNDLIEMYKSGLPFLDQGQANVFYFNDTVSLKHLLPLLYKTGFKVAMYKVLCSSEMYKHLDLSNPLPLIGKCSDGVVMHVKNIL

RIR1

Ribonucleoside-diphosphate reductase large subunit

799 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

88.581 kDa

MAAAHLGMPVPVYMAEREEDLALRKLIDTLKISAGWDLEANRMAGRLYHFVMGRRAPVDTRAYVTTFGDKLEKGVHRFLWDNARDIDDLCKDFQNGPEYERLISRGMLSAKRMYDTYVLRTEEGGGEGAVYESALQMYARMAAFFTCQCFAYPSLRKTVSEVEGGSGRMESGLDFFAYFFKILASQLVSCATPVMRSAGLRQSYLASCFIMNPDMSTEDKTLSAVFRDLSPLLCSKSGVGMNLTNFSSGGKNVQSCLRLINSQVEFCNDKNLRPVSVAAYMELWHEQIEEFLAAKLPENPERCQSIFQGVCVPGLFFRLYEQNPDSQWHLFSPKVGGHLAGLYGDKFDEEYARLVRHGLYSSSLPAKSLMFALISAIIKTGSPYILSKDAINRHHWFETQGNAISYANLCAEVVQQPHEFTSTCNLANVCLPACLRARGEGEGAGAAGEGEGADRLSPLTPDLEFCFDTLRAAVRAAVYMINASILGGVCPTPGVRVMQAERSAGIGVQGLADVFAKLGRGYMDAESALLDARIFEVMYYQAVRASNQLVTVGGAPPHANWKNSKLSRGEFHWESWGVQYDSLFIERQLWEELRESVTKHGTFNSQFIALMPTAGTSQLTGLSESFYPFYANVSSKVSNKEEVMKPNITFLERVSPSDVPLLKYHGGDVSKLPPPLAAKYRNFLTAFDYSPEDQIRRAAARSPFVDQSQSFSFFLKEANVKSASYVKNLILLGHGLGLKTIMYYCRIQKQTSLTALECLQCTESPDSGDGVGGYKGGDEEPRSPEHAQCESPDRCLSCQ

RIR1

Ribonucleoside-diphosphate reductase large subunit

792 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

88.806 kDa

MSVRTFCQVHLGAVPPERRGSQVSAGQLSDFDMCAQSLIDFLKVRVGWDVRANAMAGRLWHQIMEARCPATLKQYLGIFRGVLGHRVESFIQKNIDALEDMLCAYRRSKAYEDTLNCGYLSAVRLYDTYVLRTMGTEPVYESVAQMFMRVSVFVACQCLEHECLYWLARDLIEDAKSVSEMAIVEYVFGYLAAQHVCCATPILRSAGVEGGQLASCFILQPSMMNEPGTLDALYHDMSPLLASKSGVGLDVTSFSHQKNIASCLKLVDAQVHYFNDNNIRPVGASAYMELWHSQICDFLNAKLPENPDRCHSLFQGVCIPTLFFRMYEKDPSKLWYLFDPATAPNLIKLYGAAFDNEYERLVRAGKYVSCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMAINCSNLCAEIVQLPGRNTSVCNLANICLPKCLRTVESARVGTTDANRPFFCFEALGDAVRVAVLVINACILGGSHPTPGVERGQKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQGVPFHGWEVSNFAKGRFHWQTWEGEDASFVPRHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVLRPNVTFFKKVLPDDLRVVRQYGGDVSTFPKHHRERYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDRVRNASYLRDLLLHGYRLGLKTLMYYCRVQKQSSLTALQCLADPGSPPHSGMKQDGAWLPGPKNPEEESCAADPECLVCQ

RIR1

Ribonucleoside-diphosphate reductase large subunit

790 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

88.399 kDa

MALNFLQSDCPLAIIQDVISRVDAISDYGYANELSTTLPPRPSRSQVLEYITRVVDTLKPRCRVDERLYVVCGELVHLRIRTRNVEDLKYWLNSTEIALNEIVEKDILDHLDFIQRTLHAFESSEYRELCALGLQSALKYEEMYLAKMRGGRIESMGQFFLRLATTATHYTMEEPAMARVLVSGEVGWTYIFKAYFTALAGQVLIPATPIMLFGGRDCGSLASCYLLNPRVTDMNSAMLALMEEAGPILCNRGGIGLSLQRFNTPPKEGCSRGVMALLKLIDSMTMAINSDGERPTGVCVYFEPWHADIRAILNMRGMLARDETVRCDNIFACMWTPDLFFDRYQRYLDGESGVMWTLFDDTASHLCHMYGKEFEEEYERLEQCGFGVDSIPIQDMAFIIVRSAVMTGSPFLMFKDACNKHYHFDLRRKGAIMGSNLCTEIIQHADETQNGVCNLASINLPKCLAIPPPHTAGVPYFDFAALGRAAATATIFVNSMMRAGTYPTVKSQRGVDENRSLGLGIQGLHTAFLMLDLDMASPEARQLNKQIAERLLLNSMKASATLCRLGMKPFKGFEDSKYSLGELPFDSYPGVTLANRNAWRRLRTEIKQHGLYNSQFVAYMPTVSSSQVTESSEGFSPVYTNLFSKVTATGEVLRPNLLLMRTIRSIFPRECARLQALSTLEMAQWSVVGAFGDLPVGHPLSKFKTAFEYDQRTLIDMCADRAPFVDQSQSMSLFITEPADGKLPASKIMSLLVHAYKRGLKTGMYYCKIKKATNNGVFVGGDLVCTSCSL

RIR1

Ribonucleoside-diphosphate reductase large subunit

789 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

88.047 kDa

MALDFLSTDCPLGIVSDIISNVNTIKEYGYSSELSTTLAPRPSREQVLEYITRVVDKLKPLCRVDERLYIACGELVHLRIKARNTDLKYWLKSSEIDLSDVVEQAILEHIDFVQKTLNSFETSEYRDLCSLGLQSALKYEEMYLAKMRGGRLESMGQFFLRLATTATHYTMEQPAMARVLVSGEVGWTYIFRAFFTALAGQVVIPATPIMLFGGRDCGSMASCYLLNPRVTDMNSAIPALMEEVGPILCNRGGIGLSLQRFNTPPTEGCSRGVMALLKLLDSMTMAINSDGERPTGVCVYFEPWHADIRAILNMRGMLARDETVRCDNIFACMWTPDLFFDRYQRYVDGESGIMWTLFDDTASHLCHMYGNDFTREYERLERCGFGIDAIPIQDMAFIIVRSAVMTGSPFLMFKDACNRHYHFDMRQRGAIMGSNLCTEIIQHADETQNGVCNLASINLPKCLALPPPNIAGVPYFDFAALGRAAATATIFVNAMMCASTYPTVKSQKGVEENRSLGLGIQGLHTTFLMLDLDMASPEAHQLNKQIAERLLLNSMKASATLCKLGMQPFKGFEDSKYSRGELPFDAYPNVTLTNRNAWRRLRTDIKQYGLYNSQFVAYMPTVSSSQVTESSEGFSPVYTNLFSKVTATGEVLRPNVLLMRTIRSIFPQECARLQALSTLEAAKWSVVGAFGDLPVGHPLSKFKTAFEYDQTMLINMCADRAAFVDQSQSMSLFITEPADGKLPASRIMNLLVHAYKRGLKTGMYYCKIKKATNNGVFVGGDLVCTSCSL

RIR1

Ribonucleoside-diphosphate reductase large subunit

787 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

86.01 kDa

MASDAFMQTACPADAAEQLEAEHAEWAQLGCGAVPPPPAAASRPSRAAVAAYVGEVVDRMRAQSRADERVYVKCGQLVHLRVRARSVPLDDWLTSAELALVSEVAEPVRANRAFVEVSLRYFELTEYATLRALGLQSALKYEEMYLAKLEGGAIESMGQFFVRIAATAATWTMREPAFGRALVGEGATWCAVFNAYLTALYRQLVVPATPIMLFAGRARGSLASCYLLNPQVSSSTEAVEAITTEVARILLNRGGIGISFQSFDRAVSRDCKRGIMGALKLLDSMAMAINSDSERPTGICVYLEPWHCDVRAVLNMRGLLARDESTRCDNLFSCLWVPDLLFDRYLAHLEGREGVVWTLFDDRASHLSRLHGPAFTAEYERLEREGLGVETVPVQDLAFLIVRSIVMTGSPFVMFKDACNRHYHMDTAGDALTGSNLCTEIVQRASPDAHGVCNLASVNLPRCVREGEGGALAFDFAALSTAAATAAIFVNAMMLGGQYPTEKAARGVARHRSLGIGFQGLHTLLLELGMDMLSPAARRLNVEIAERLLLAVMATSATLCEYGCAPFEDFARSKFARGLMPFDGYEGVVLSLPRAWARLREKVARHGLYNAQFVALMPTVSSSQVTEGSEGFSPVFTNMFSKVTMSGELLRPNLPLMRALRKHFTREASRLGAVRALDREQWSVAAALGDLAPGHPLAKFKTAFEYDQERLIDLCADRAPFVDQSQSMSLFVTEPMDGKVPASQIMNLLVYAYKKGLKTGLYYCKIRKATNNGVFTGGDLVCSGCHL

RIR1

Ribonucleoside-diphosphate reductase large subunit

780 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

87.362 kDa

MASAEATPQQQIDQLKVNAGWDMKSNIKAGLLHHEEMEKKATKTVTEYIEKFADVLEENVLRFLQDNAEMLELCIYMYEQLPAYKAVKSRGILSAKRFYDTYVLRTADGSCYESVSHCFMRIAAFCTVQVLTNSALKITILYLGRDKLFKDLPCSPTMDLFIYFFSPLSHQLVCCATPIMRSAGLRDANLASCFLINPDLSTEKSTTTALLQELTMLLSAKSGVGCNVTSFGVDEKCIQSCVGLINSQVEFFNDQNPRPVSVAAYMEVWHSQIQEFLAVKLPENPSRCASIYQGLCIPKLFFEKFIEDPGQNWYLFKPEKSGNLANLYGDEFRSEYERLVGIGCYADAIPIKSLMFLIINTIIKTGSPYIIYKEACNEHHWKNMEGCAIASANLCAEVIQYPGADVSTCNLANVCLPMCLVTVSNDSHSPLEKTYCGNVIESQAVSGVGFSMPILHAAVEVAVFLVNCAIAGGKCVTPGMERGQRERSMGIGVHGLADVFAEMGYSYLDERAARLDVEIFENMYFRAVKTSNNICRLGGGRPFEGWGESKLRHGFFHWQGWEDVNLSIPITEWEKLSRRCISSGVYNSQFIALMPTVGSSLLTGFSESYYPYFANISSKVSSKEEVMKPNMTFWNRVSKEDLDTVRFFSGDVALFPEPLKEKYSLFLSAFDYCAEKQLARARLRAPFVDQSQSHSFHLKEENVVSARFLKDLILSGYTLGLKTIMYYCKVKKQSTMSSFQCLRDQNKSEMTGNDQGVEPESYIKCTAAGGETSEACLHCQ

RIR1

Ribonucleoside-diphosphate reductase large subunit

775 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

86.828 kDa

MEFKRIFNTVHDIINRLCQHGYKEYIIPPESTTPVELMEYISTIVSKLKAVTRQDERVYRCCGELIHCRINLRSVSMETWLTSPILCLTPRVRQAIEGRRDEIRRAILEPFLKDQYPALATLGLQSALKYEDFYLTKLEEGKLESLCQFFLRLAATVTTEIVNLPKIATLIPGINDGYTWTDVCRVFFTALACQKIVPATPVMMFLGRETGATASCYLMDPESITVGRAVRAITGDVGTVLQSRGGVGISLQSLNLIPTENQTKGLLAVLKLLDCMVMAINSDCERPTGVCVYIEPWHVDLQTVLATRGMLVRDEIFRCDNIFCCLWTPDLFFERYLSYLKGASNVQWTLFDNRADILRTLHGEAFTSTYLRLEREGLGVSSVPIQDIAFTIIRSAAVTGSPFLMFKDACNRNYHMNTQGNAITGSNLCTEIVQKADAHQHGVCNLASINLTTCLSKGPVSFNLNDLQLTARTTVIFLNGVLAAGNFPCKKSCKGVKNNRSLGIGIQGLHTTCLRLGFDLTSQPARRLNVQIAELMLYETMKTSMEMCKIGGLAPFKGFTESKYAKGWLHQDGFSTISYLDLPWCTLRDDICAYGLYNSQFLALMPTVSSAQVTECSEGFSPIYNNMFSKVTTSGELLRPNLDLMDELRDMYSCEEKRLEVINILEKNQWSVIRSFGCLSNSHPLLKYKTAFEYEQEDLVDMCAERAPFIDQSQSMTLFIEERPDGTIPASKIMNLLIRAYKAGLKTGMYYCKIRKATNSGLFAGGELTCTSCAL

RIR1

Ribonucleoside-diphosphate reductase large subunit

775 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

86.828 kDa

MEFKRIFNTVHDIINRLCQHGYKEYIIPPESTTPVELMEYISTIVSKLKAVTRQDERVYRCCGELIHCRINLRSVSMETWLTSPILCLTPRVRQAIEGRRDEIRRAILEPFLKDQYPALATLGLQSALKYEDFYLTKLEEGKLESLCQFFLRLAATVTTEIVNLPKIATLIPGINDGYTWTDVCRVFFTALACQKIVPATPVMMFLGRETGATASCYLMDPESITVGRAVRAITGDVGTVLQSRGGVGISLQSLNLIPTENQTKGLLAVLKLLDCMVMAINSDCERPTGVCVYIEPWHVDLQTVLATRGMLVRDEIFRCDNIFCCLWTPDLFFERYLSYLKGASNVQWTLFDNRADILRTLHGEAFTSTYLRLEREGLGVSSVPIQDIAFTIIRSAAVTGSPFLMFKDACNRNYHMNTQGNAITGSNLCTEIVQKADAHQHGVCNLASINLTTCLSKGPVSFNLNDLQLTARTTVIFLNGVLAAGNFPCKKSCKGVKNNRSLGIGIQGLHTTCLRLGFDLTSQPARRLNVQIAELMLYETMKTSMEMCKIGGLAPFKGFTESKYAKGWLHQDGFSTISYLDLPWCTLRDDICAYGLYNSQFLALMPTVSSAQVTECSEGFSPIYNNMFSKVTTSGELLRPNLDLMDELRDMYSCEEKRLEVINILEKNQWSVIRSFGCLSNSHPLLKYKTAFEYEQEDLVDMCAERAPFIDQSQSMTLFIEERPDGTIPASKIMNLLIRAYKAGLKTGMYYCKIRKATNSGLFAGGELTCTSCAL

RIR1

Ribonucleoside-diphosphate reductase large subunit

767 amino acids

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Belongs to the ribonucleoside diphosphate reductase large chain family.

87.216 kDa

MSQETIISNLIDMLKVSAGWDREANEISGRLFHKLMDMSSTETISQYMSLFGPLLEPHILEFIQNYEQEIDEVCLEYRASYDFMCLRNCGILPAKRFYDTYVLPPRTEMNGKYESIPHFFARIAAYCAWNCIMCEPLKDTLVYVQKRDWNVEIKTDMQIFKYFYKVISSQLVCCATPVMRSAGVAGENLSSCFIIAPTLDTEKSTISSIFGELAPLLASRSGVGVDVTKFSFGGKNIHSCLKLINAQVEFFNDKSVRPVSVATYIEVWHCQIHEFLSAKLPENPDRCNSIFQGVCVPSLFFKMYESDPNGLWYLFDPQDAPNLTRLYGLEFEEEYLRLVSEKKYKQSVTLKSLMFSLINTIIKTGSPYVISKEAMNKHHWYETQGEAINCSNLCAEIVQQPKQFTSTCNLANVCLPKCLNSSNFPYTCSNTAQFDFSKLEYAVQAAVFIINACILSPSPTSSATVGQRERSMGIGCHGLADVFSEMGYGYLDLESECLDRDIFETMYYTAVKTSSEICSVGKGQPFAGFRKSKLAHGVFHWATWDAMPQRVPMKQWIHLQDNIKKFGVFNSQFIALMPTAGTSQLTGYTDSFYPYFANMSSKVSNKEEIMKPNITFLKNVKPQDLCTVRFYGGDVSMMPEDVSTRYKHFLTAFDYCPEAQMRRASIRAPYVDQSQSLTLFLTEENVQSAKYLKDLLLLGFRLGLKTIMYYCRVKKTTKLLQLECLKLDEHTKKDAQIVLADLARELPDSHKTEDACPLDQSECIACQ