PSD2

Phosphatidylserine decarboxylase proenzyme 2

1138 amino acids

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (PubMed:7890740, PubMed:7890739, PubMed:24366873). Phosphatidylethanolamine produced by PSD2 is insufficient to completely provide the PtdEtn pool required by mitochondria under respiratory conditions (PubMed:11294902). PSD2 is also involved in the PtdSer transport step to the site of PtdEtn synthesis on the Golgi/endosome membranes (PubMed:24366873). Required for normal heavy metal resistance (PubMed:20016005).

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.

130.065 kDa

MRIIKGRKRGKNKKPTLILKIHVIQAENIEALKTFNCNPVCFVTTNTFYSQKTNKLKNSNTHWNQTLRIKLPRNPTSEWLRIIVYDALPTGAPPTTPSRPRTTTANTSSSTLSNSGLSSHSHSSRNLNVTSKGNQTSTSINSVSSSATPAPSHSSSSLSTTGPGSTHKNRINSYLYLGEAKISLLDLFKRKDTTTSYKFSIEAQRYHLYDMKGGKDQDSLNCNFLVGDILLGFKLECNVKRTPTFQAFNAWRNELNTYLGRIDRNKARMRSSSSLPPPLEDMLSNSSAVSGNEIRREKPYSDTDLAHDEEVNAEDEIDAEESIEDMNSSGSICTERRYDIDNDTIFDSISEVVSLNDEELDILNDFEEADHPNVPDINVHDIDEDTRISLSSMITALDEYDIVEPEDVAKLPAVSENDITSVDDEESENQQESDEEFDIYNEDEREDSDFQSKEYIGSRLLHLQRGKHNKSYANYLYRRAKSNFFISKKEHAMGVVFMHIGAIKNLPALRNRLSKTNYEMDPFIVISFGRRVFKTSWRKHTLNPEFNEYAAFEVFPHETNFAFSIKVVDKDSFSFNDDVAKCELAWFDMLQQQQHENEWIPYEIPLDLTVEPAHAPKQPVLYSSFKYVSYPFLKKSFWKEAVDTSVNLERLDIIQVMLYLERLGSFTMADSFELFQHFNKSAWAGQSITRSQLVEGLQSWRKSTNFKRIWTCPRCMRSCKPTRNARRSKLVLENDLITHFAICTFSKEHKTLKPSYVSSAFASKRWFSKVLIKLTYGKYALGSNNANILVQDRDTGIIIEEKISAHVKLGMRIIYNGKSPESKKFRSLLKTLSIRQGKKFDSTASAKQIEPFIKFHSLDLSQCRDKDFKTFNEFFYRKLKPGSRLPESNNKEILFSPADSRCTVFPTIQESKEIWVKGRKFSIKKLANNYNPETFNDNNCSIGIFRLAPQDYHRFHSPCNGTIGKPVYVDGEYYTVNPMAVRSELDVFGENIRVIIPIDSPQFGKLLYIPIGAMMVGSILLTCKENDVVESGQELGYFKFGGSTIIIIIPHNNFMFDSDLVKNSSERIETLVKVGMSIGHTSNVNELKRIRIKVDDPKKIERIKRTISVSDENAKSTGNVTWEYHTLREMMNKDFAGL

PSD2

Phosphatidylserine decarboxylase proenzyme 2

1070 amino acids

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Important for virulence (PubMed:20132453).

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.

121.666 kDa

MRSSGYLNSNNGSSSSLESTNVNKSTDKNQLYLKVVCNCATDLVPQDTTGTGSESKKAYSSSKSINPVLVVQLNNTIKSTSKKLNTNQPSWNDELYMPLKNQDDSSLLIFSVWDKHTRYKNYLGELRLNVKDIFVDNGNFVDKTELKWYHLNSNTKYHSFVTGSILAGFELVIKNKKKRFHSSYNDKFQQLSIDSDVESAFKKWLSSLTKPTIYSVNNKINPNDQGFYDDELVNEFELESVLTERSKKSHLNVPGGNGLLSVPGDDCHDAGSFSDASFLSDGGYASDASANLFDQKETSSDSKKSRIKSKMRLRRSKQEYENFELASRQVLGVVFIEIVSCEDLPPYKNFTRTSFDMDPFVVVSFGKKTFRTGWKRHTLNPVFNERLAFELLPHESNFSIQFLVLDKDHFSFHDNVAHISLPLRTLTEYATAKPTEGDSSDVNTSDSTSFSQTGNGFTTEDTEFPENDSVQIIENETPSNKQSRKRYLSRKKVVGTQLDLKKFKAMSLSLQLHDQKYIGKYAPKLKIRVRFETYTELRKKFWRVLLEESNSTPENRDSCDYIELISLLDTLGCVNSDELVELFYSNLGKSSWGGDLLTFDEIIDQMETYVNQNVESGKVKIFEFEKCPICNEKRVSKKQDLDIITHFAICASKDWSVVGKLLSSSYVTPTQATKKWFTKALIKLTYGKYKLGGNSANILVQDRMTGIIVEEKMSVYVRLGIRLLYKGLDKARSKRVRILLKNMSIKQGKKFDAPQSKSDIASFIKFHKLDLDECEIDDPSQFATFNDFFYRKLKPGAREIEDEKNSKIVTSPADCRSVVFESIDKATQLWIKGAGFTIPKLIHNDHSMRVSSYTLGIFRLAPQDYHRFHSPVDGVIESIKHIDGEYYTVNPMAIRSELDVFGENVRTIVTIKTKDFGNIYFIAVGAMMVGSIVLTKDTGYEISKGEELGYFKFGGSTVLLLIESDKFKFDTDLVKNSSSGLETLLRVGQSIGHSPDVEEYKRDHISFDKLDKSKQLRLIRVLTGGDLKDKHKLSNWEATKIDMEDFQEIEDEEVFDKDMPDEDASIKSED

PSD2

Phosphatidylserine decarboxylase proenzyme 2

1010 amino acids

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.

116.241 kDa

MSQAFNLVLFTEIKQAQNVKTGNDKEPNSKLRAIVRISERSSKKTPRATPRDDFVYTWNSTISLKLRSQLKLPLIQISVWDKQAHRSVYVGEVRFFLIGLLKSLAYNEHTSSWESTPQWYQLYSSEDKKSFSSGTILVQFRVQQHLSKKNLFFNAKSDVTLSDQTGSSDLLNQYIQAIETSTPRSLQKKAFDLSNPNEQRFYPDIETNALASSILDCEIDSMLEDFTYRKPNITESSLHDDTLTDTDFESIHSDPTIPSSALVPKRILFIEILSVTDLPPYKSFTRATFDMDPFVVISFGKRTYRTSWRKHTLTPVFNERLAFEVCDYEKNYDLQFSVLDKDKFSFHDQVATGFVSVSELLEEKTTDKPCTDFKPTSSNLILLDKPMNANESADNLLDTKKKKYKRNVNTDATLQGGLLRKYELVMSLDGKKNWSRKTKDEYIPILKFNTRFERYEILRRQLWMHLLQGNDTQMKGTLDLIELNYFVDCLGSNLSDKTLASFFEYYDKNPWVGETLTIEQVIDSLERLVFKRQCANTHENYIINIDTCPLCGQGRLSLRQDLDILKHLSICASRDWSTVNKVLKPSFVSSKAATRRWYSRLLIKLTFGQYTLGGNSANILIQDRDTGYILEEKMNIHVRLGIKLLYKSFDKANSRKIKTLLRKLSIRQGIKFDSPSSVSQIPSFIKFHKLDVDDCLLQLDEYKTFNEFFYRKLKPGSRPQEDENNSNIATSPADCRCTVFESITFAKTFWIKGRNFTTKKLFGSFYSREMADLYDECSIGIFRLAPQDYHRFHSPVTGTVGKVQSISGEYFTVNPMAIRSDLDVFGENVRCLLPIQTKEFGRVLVVPVGAMMVGSIILSVKENQEVKKGDELGYFKFGGSTLLVLFPNKRFKFDSDLLANSNNKIETLIKVGMSIGHTPEEPQFERHYRSFEEEPVDQQLRIIRCITGGSTFEESKQATQRRNELLGNEGSPQEKDLQVENLSWEAKNMNLEELEENESLLLYDLVNDGT

PSD2

PH and SEC7 domain-containing protein 2

771 amino acids

Belongs to the PSD family.

84.66 kDa

MEEDKLLSAVPEEGDATRDPGPEPEEEPGVRNGMASEGLNSSLCSPGHERRGTPADTEEPTKDPDVAFHGLSLGLSLTNGLALGPDLNILEDSAESRPWRAGVLAEGDNASRSLYPDAEDPQLGLDGPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDGLSLTDESDSCVSFEAPLTPLIQQRARDSPEPGAGLGIGDMAFEGDMGAAGGDGELGSPLRRSISSSRSENVLSRLSLMAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSDSDSELSSSEGLEPGSADPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQLTAELAEHRCHPVERGIKSKEAEEYRLKEHYLTFEKSRYETYIHLLAMKIKVGSDDLERIEARLATLEGDDPSLRKTHSSPALSQGHVTGSKTTKDATGPDT

Psd2

PH and SEC7 domain-containing protein 2

770 amino acids

Belongs to the PSD family.

84.299 kDa

MDEEKLPCELHKEGSATQEDHGLEPEEEPGLQNGTAASEGLSSHISGPGGEKTLEGTMEPVRGPDVALPGLNLSLTNGLALGQDGNILEDSIEFKTWRSGPAEEEDVPGSPCPDAGDPQLGLDCPGEPDVRDGFSATFEKILESELLRGTQYSSLDSLDVLSLTDESDSCVSFEAPLTPLIQQRARDSPEAGAGLGNGDMGPEGDLGATGGCDGELGSPLRRSISSSRSENVLSHLSLTSVPNGFHEDGPGGSGGDDEDDEDTDKLLNSASDTSLKDGLSDSDSELSSSEGLEPGSTDPLANGCQGVSEAARRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDRALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALNATTYKHGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRLDKALSEGDLKNAIRVHHALATRASDYSKKSNVLKLKTADWRVFLFQAPSKEEMLSWILRINLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKLRQVTAELAEHRCHPLERGLKSKEAEEYRLKEHYLTFEKSRYETYIHLLAVKIKVGSDDLERIEARLATIEGDDPALRKTHSSPALSLGHGPVTGSKATKDTSASDT

PSD2

Phosphatidylserine decarboxylase proenzyme 2

635 amino acids

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Contributes only to a minor proportion of PtdEtn production.

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.

71 kDa

MGNGNSREAKESRRSRLRHKLQKFRIHRRHLRSSRNSAGMVIQRTVSAEDFSGIALLTLIGAEMKFKDKWLACVSFGEQTFRTEISDTTQKPIWNSEKKLLLEKNGPSLARVSVFETNRVARNKIIGYCELDIFDFVVQEPESTCKSFNLLDPTSSNVVGSIFLSCAIEDPVETERRFAKRILSIVDYNEDGQLSFSEFSDLIKAFGNLVAANKKEELFKAADLNGDGVVTIDELAALLALQQEQEPIINNCPVCGEALQVSDKLNAMIHMTLCFDEGTGNQVMTGGFLTDRQASYGWMFKLSEWTHLSTYDVGLNTGSSASYIVVIDRKSKRLVEELIDSKIVLSMRAIYQSKIGLRLMDQGAKEILQRLSEKQGKKMSSVESAQKIPRFLEFFKDQINMAEVKYPLQHFKTFNEFFIRELKPGARPIACMNRNDVAVCAADCRLMAFQSVEDSTRFWIKGKKFSIRGLLGKNVNPNAFLDGSLVIFRLAPQDYHRFHVPVSGVIEQFVDVSGSLYTVNPIAVNSKYCNVFTENKRTVAIISTAEFGKVAFVAIGATMVGSINFVRKEGEHVKKGDELGYFSFGGSTVICVFEKDAIGIDNDLLVNSGRSLETLVSVGMQLGVSTRTFARSTLI

PSD2

Phosphatidylserine decarboxylase proenzyme 2

624 amino acids

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.

69.055 kDa

MGHSPSRHNACGGGGGDGESPPSPLPSRFERFRRRLRLRHRDRAGRPGGDAHASESGTGRAIAVDEFAGIARIRIVKEKKVVVETNGPHIARISVFETNRFSKNTLVGYCEVDLFELLTKDLDEHSEVLSLLDPSSSATIVGSISISCYIEDPVETEQSFARRVLAIVDYNEDGELSLSEFSDLMKAFGNKLAVAKIEELFRQADKNGDGIVDMDELAALLANQQEKEPLISNCPVCGEILGKHDKINDMIHMTLCFDEGTGNQIMTGGFLTDKQASYGWMFKLSEWAHFSSYDVGLHSGSTASHILVFDRRTKRLVEEVIDGKIVLSMRALYQSKVGLTLIDTGVKDLLKNLSEKQGKKMSSPESAKDIPKFLELFKDQINLDEVKDPLESFKTFNEFFVRQLKPGARPIACYEQDTIATCAADSRLMTFSSVDESTRLWIKGRKFSIEGLLGKDVHSDALCNGSLVIFRLAPQDYHRFHVPVSGTLEKFVEIPGCLYTVNPIAVNSKYCNVFTENKRVVSIISTSEFGKVAFVAIGATMVGSIEFLKEEGDYVHKGDEFGYFAFGGSTVICVFEKDAIEFDADLLANSARSLETLVSVGMRLGVSTRNRDLQPQELEKCSLE

psd2

Phosphatidylserine decarboxylase proenzyme 2, mitochondrial

516 amino acids

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Together with psd1 and psd3, responsible for the majority of phosphatidylethanolamine synthesis (PubMed:19286980).

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.

58.464 kDa

MRPRQRFRRFHPRWSKVNLRGFGGVGALKGVKALNGMNVRVSMRLKWISNRIHRIRRSRRLGRLSISVRPNGSWQVYLLSSLPLRSLSRVWGQFNRAHLPTFLRTPGFKLYAWVFGCNLSELKDPDLTHYRNFQDFFCRELRPETRPVDPVSPVVSPVDGRIVCQGVVDNNRIQHVKGLSYSLEALLGGISSSNPLVVNFEDEITPDLIQKHEQFAEQHSISLNSNNRYRKADASAAVVDEHSDEEALLCAFTDHPHFYLNDSRNSLNYFCPFSAFEDISNSVRSSCGKRLSPSSNFDLNNLGGDDDLRSESSSDFESAPASILEHEPTNWDDWVQEADVTDIDSLPWHNIRPGNKLFYSVIYLAPGDYHRFHSPADWVIESRRHFSGELFSVSPFLARRLHNLFVLNERVALLGRYEHGFMSMIPVGATNVGSIVINCDPTLSTNRLVLRKKSLGTFQEAVYKNASPVLDGMPVSRGEQVGGFQLGSTVVLVFEAPADFEFSTYQGQYVRVGEAL

psd2

Phosphatidylserine decarboxylase proenzyme 2

291 amino acids

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).

Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.

34.07 kDa

MSITIFNRDLKEIYYEKQYKNGQLKFLYNTILGRMLLKLFISTRLFSKINAIFNNNKGSIKKIEPFINEYKIDMSEYEKKEYTSFDDFFTRKILEGKRSFSKEKSHLISPADSKLMVYEIDDDLKMNIKNSIYTVGELLNDEKLSREYKNGTCLIFRLTVDDYHRYCFIDDGSLKYRKVINGRLHTVGPISSKRYKVYSENNREYSVLKTRNFGKVIQIEVGALLVGKIKNHSIKVFKKGDEKGYFCFGGSTIVLLFKEKVIKMDEDILEYSKAGIETKIKMGEKIGETND