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PIH1D1

Gene
pih1d1
Protein
PIH1 domain-containing protein 1
Organism
Xenopus laevis
Length
297 amino acids
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Similarity
Belongs to the PIH1 family.
Mass
33.656 kDa
Sequence
MESDKSLLSAELNSEFEQALYEQMLLKAKQEMQNRLPNTPESKQIRPQPGFCIKTQTSEKAKIFINICKTNDIPAPPDLSEAELVNILESDDPSGYRVPMSIGEPHVEVDNSGNGCTVYDIVINSTFFDKMKSNELFREFFITVAMEGLENKYEMELSRDWRMLKNRKFMGSISDQNIRTKSKPIIQELDTSSSQTLQSKPLISEIQSSPKVPEYTIAAEPSEGHPSFLVAEISLPNVTSVRSLVLDLGEDRIVLWGRPDLYHLDIFLPYNIVQEESGAQFNRDTKVLTITMPVQTI
Protein
PIH1 domain-containing protein 1: pih1d1

Gene
PIH1D1
Protein
PIH1 domain-containing protein 1
Organism
Bos taurus
Length
290 amino acids
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Similarity
Belongs to the PIH1 family.
Mass
32.415 kDa
Sequence
MADSKMLVPELNDAETMGAETSRFEELLLQASKELQQAQTSRPESTQIQPQPGFCIKTNSAEGKVFINICHSPSIPPPADLTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFFRRMQNSDFLRELVITIAREGLEDKYGLQLNPEWRILKNRPFLGSISQQNIRSQQRPRIQELGNLHTPSSPRPEAGPEKPHLSLWLEAPDLLLAEIDLPKLDGALGLSLEVGENRLVMGGPQQLYHLDTYIPLRINCDESKAAFHQKRKQLMVAMPLLSVPS
Protein
PIH1 domain-containing protein 1: PIH1D1

Gene
PIH1D1
Protein
PIH1 domain-containing protein 1
Organism
Homo sapiens
Length
290 amino acids
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).
Similarity
Belongs to the PIH1 family.
Mass
32.363 kDa
Sequence
MANPKLLGMGLSEAEAIGADSARFEELLLQASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS
Protein
PIH1 domain-containing protein 1: PIH1D1

Gene
Pih1d1
Protein
PIH1 domain-containing protein 1
Organism
Mus musculus
Length
290 amino acids
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Similarity
Belongs to the PIH1 family.
Mass
32.209 kDa
Sequence
MADSTFLAPELSDTESMGEETVRFQELLLKASKELQQAQTARPDSTQIQPKPGFCVKTNSSEGKVFINICHSPSIPPPADVTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSNFYLRMQNSDFLRELVVTIAREGLEDKYGLQLNPEWRMLKYRSFLGSISQQNIRSQQRPRIQELGTLDASGSLGTCHGPERPHLNLWLEAPDLLLAEVDLPKLDGAQGLALEIGENRLVIGGPQQLYHLDATVPLRINSEASRAAFHRRRKQLMVSMPLLTASS
Protein
PIH1 domain-containing protein 1: Pih1d1

Gene
Pih1d1
Protein
PIH1 domain-containing protein 1
Organism
Rattus norvegicus
Length
290 amino acids
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Similarity
Belongs to the PIH1 family.
Mass
32.361 kDa
Sequence
MADSKLLAPELSDAESMGEETVRFQELLLKASKELQQAQTARPESTQIQPKPGFCIKTNSSEGKVFINICHSPSIPPPVDVTEDELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSNFYLRMQNSDFLRELVVTIAREGLEDKYGLQLNPEWRMLKYRSFLGSISQQSIRSQQRPRIQELGTLDTHDSLGTRHGPERPHLNLWLEAPDLLLAEVDLPKLDGAQGLALEIGENRLVVGGPQQLYHLDACIPLRINSEASRAAFHHRRKQLMVSMPLLSASS
Protein
PIH1 domain-containing protein 1: Pih1d1

Gene
pih1d1
Protein
PIH1 domain-containing protein 1
Organism
Danio rerio
Length
287 amino acids
Function
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
Similarity
Belongs to the PIH1 family.
Mass
32.03 kDa
Sequence
MDTDASLLLGVEHEQKQQEELYQQLLLQTMGKLQSDSPPSKVIRPQPGLCVKTSSVSDKKKVFLNICQSQTVPPPPHLSQEALVELLESEDPTSYRVPMSLGEPHTEVDNSSQGCTVYDVVINDEFFQKCEKDTLFQQFLIAVSLEGLENKYSLELSRDIKILKNRKFMGSIAEQNIRTKSKPIIQEIDSKESLTLPSAAKRPEFTLLVEPPSGKAEHLIAEILLPGVSSARSLVLDLGEDRLVLIARPSLFHLDIFFPVLIDQENSVAQYNTNTQTLTVTMPVVSL
Protein
PIH1 domain-containing protein 1: pih1d1