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PF08_0084

Gene
PF08_0084
Protein
U1 small nuclear ribonucleoprotein C
Organism
Plasmodium falciparum (isolate 3D7)
Length
235 amino acids
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Similarity
Belongs to the U1 small nuclear ribonucleoprotein C family.
Mass
27.878 kDa
Sequence
MPKYYCEYCDIYLTHSSPVGRRQHIHGRKHISAKIEYFQNLLREEGITPQNFLGFLNNRNINNPLGNPMMNYMNPNMYMKYNPMKSYHSYSMRSSHPYRLNIHNNKYSRAGYVPPSHHKYSVNPMHNNYHQAHNNYSYPNSINPSNQINYSNNYGSNNFNNSNEFNKNMNEKDNINNNDIHDNKVKTDENDPINNDNLNNTRNFSYEENHYSTDHKKPSFLNPENSKEHIESDIS