Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.

Belongs to the U1 small nuclear ribonucleoprotein C family.

235 amino acids

MPKYYCEYCDIYLTHSSPVGRRQHIHGRKHISAKIEYFQNLLREEGITPQNFLGFLNNRNINNPLGNPMMNYMNPNMYMKYNPMKSYHSYSMRSSHPYRLNIHNNKYSRAGYVPPSHHKYSVNPMHNNYHQAHNNYSYPNSINPSNQINYSNNYGSNNFNNSNEFNKNMNEKDNINNNDIHDNKVKTDENDPINNDNLNNTRNFSYEENHYSTDHKKPSFLNPENSKEHIESDIS

27.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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