Protein
7-methylguanosine phosphate-specific 5'-nucleotidase A
Function
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity).
Similarity
Belongs to the pyrimidine 5'-nucleotidase family.
Sequence
MRLPVLGKDTVRMRDPEGLQDKITRIQRGGQEKLQIISDFDMTLSRFSRNGERCPTCYNIIDNSNIISDEGRKKLKCLFDIYYPLEIDPKKSIEEKYPLMVEWWSKAHDLFYEQRIQKDRLAQVVKESQATLRDGYDLFFNSLYQREIPLFIFSAGIGDVLEEIIRQAGVFHPNTKVVSNYMDFDDNGILTGFKGDLIHTYNKNSSVLKDTEYFKEISHRTNILLLGDTLGDLTMADGVSTVENIIKIGFLNDKVEELTEQFLQSYDIVLLRDETLDVVNGILQFVTAKN