nudt18

8-oxo-dGDP phosphatase NUDT18

325 amino acids

Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity).

Belongs to the Nudix hydrolase family.

36.9 kDa

MDSQSSILEENLEKILRGEGLEFDSVAEQVDPVTLRKNVCYIVGAVIFNSKEEVLMVQEAKRECYGRWYLPAGRMEECESILEALQREVREEAGIDCQPITLLLVQEQGPRWVRFIFLAEETGGSLKTTAEADDESLQAHWWDRKSPLPLRAHDILSLIDAGLKYRRNPWFPVTQPVDFPCHVVCQRLFLTFISSRADADDRLWLLMSNNNTSHHPRLPIVVSFRTYISKAVSKLIEDCMPSSYISVHIRGILGVQHNGRIPGKTDGICFNTLVLLENTEEGAEIGSPPSLETDCYRWQEVTNQGLKAKIIERIKDGSVLPFQSL

NUDT18

8-oxo-dGDP phosphatase NUDT18

323 amino acids

Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

Belongs to the Nudix hydrolase family.

35.501 kDa

MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCYVVLAVFLSEQDEVLLIQEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEPETLLSVEERGPSWVRFVFLARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDILHLVELAAQYRQQARHPLILPQELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTACGLDPMEQRGGMKMAVLRLLQECLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTVAFRSPGIQDEPPKVRGENFSWWKVMEEDLQSQLLQRLQGSSVVPVNR

Nudt18

8-oxo-dGDP phosphatase NUDT18

323 amino acids

Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity).

Belongs to the Nudix hydrolase family.

35.694 kDa

MATEGLAGALATVLGGKGLLVQSCDSEPAGKPLFPVRLRKNVCYVVLAVFLNEQDEVLMIQEAKRECRGTWYLPAGRMEPGETIVEAMQREVKEEAGLLCEPVTLLSVEERGASWIRFVFLARPTGGVLKTSKDADSESLQAGWYPRVSLPTPLRAHDVLHLVELGAKFCQQAMHPLILPQELPCSVVCQRLVTTFTTVQSVWVLVGTVGTPHLPITACGFTPMEQRGGIKVAILRLLQECLTLHSLAVETKGLLGLQHLGRDHVDGVCLNVLVTVAFRNPGIQDEPPKIRGENYFWWKVLEEDLQKLLLYRLQESSVIPLSR

Nudt18

8-oxo-dGDP phosphatase NUDT18

323 amino acids

Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity).

Belongs to the Nudix hydrolase family.

35.647 kDa

MATEGLAGALATVLGGKGLLVQSCDSEPAGKPLLPVRLRKNVCYVVLAVFLNEQDEVLMIQEAKRECRGTWYLPAGRMEPGETIVEAMQREVKEEAGLLCEPVTLLSVEERGASWIRFVFLARPTGGVLKTSKNADSESLQAGWYPRVSLPTPLRAHDVVHLVELGAKFCQQATHPLILPQELPCNMVCQRLVATFTTVQSVWVLVGTVGTPHLPITACGFTPMEQRGGIKVAILRLLQECLTLHSLAVETKGLLGLQHLGRDHVDGICLNVLVTVAFRNPGIQDEPPKIRGENYFWWKVLEEDLQKQLLHRLQESSVVPLTR

NUDT18

Nudix hydrolase 18, mitochondrial

176 amino acids

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Belongs to the Nudix hydrolase family.

20.416 kDa

MVCLVSRTGRQSQRYNKGRRQVVGCIPYRLKISSDGTISDEFEVLVISSQKGHALMFPKGGWELDESVEEAASRESLEEAGVVGNVERQLGKWDFLSKSKGTFYEGFMFPMLVKEELELWPEQHLRQRIWMKVDEARDACRDWWMKEALDVLVQRLSLLSLKPMEEDENLPLISIY