nfatc2ip

NFATC2-interacting protein

434 amino acids

Regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes.

47.332 kDa

MGSPTWLQGEKSSPNARGQHSPGFCPSGPQPCPKPRGPQPCPKPRGPQPCPKPRGPQPCTPALLWAPHRLEGLSQSQDGLLPTSPCFVSGTEAPTACGPCIDIESGSPHRYEASEESSDSDVELVRPRQVKRRRLLPGTVPASVSVYSNKVNSSLKLPPDNSKALLQMSELHSIRGSEDVESEIVPPVTQQKPPTKELTDSETDETEPPNTERLRTGSPSPPPTPKTPVRRKGRAYNKIREMDARLRDLGTVLSPGQKVTTEENDVIVVGSSPAPELTVKVRRGGKLFRINLAMWDPLEKLAQSMASQLNVEPSRILLLLGDEELNKSQTPKSMNLTVADIIDCVVLSPPDGQEDSDPNEKICIKVQGKEKQSHLSVMVGKVEPLQSLMDQYQAAMGLTKKHKVSFFFEGQKLKGKNTAEELGLESDDIIEVWA

NFATC2IP

NFATC2-interacting protein

419 amino acids

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

45.817 kDa

MAEPVGKRGRWSGGSGAGRGGRGGWGGRGRRPRAQRSPSRGTLDVVSVDLVTDSDEEILEVATARGAADEVEVEPPEPPGPVASRDNSNSDSEGEDRRPAGPPREPVRRRRRLVLDPGEAPLVPVYSGKVKSSLRLIPDDLSLLKLYPPGDEEEAELADSSGLYHEGSPSPGSPWKTKLRTKDKEEKKKTEFLDLDNSPLSPPSPRTKSRTHTRALKKLSEVNKRLQDLRSCLSPKPPQGQEQQGQEDEVVLVEGPTLPETPRLFPLKIRCRADLVRLPLRMSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQTLEVSLSRDSPLKTLMSHYEEAMGLSGRKLSFFFDGTKLSGRELPADLGMESGDLIEVWG

Nfatc2ip

NFATC2-interacting protein

414 amino acids

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

45.43 kDa

MAEPLRRRGPRSRGGRASRGARRARAARGRCPRAPRSPTRLIPDTVLVDLVSDSDEEVLEVVADPGEVPVARLPAPAAPEQDSDSDSEGAAEGPAGAPRTLVRRRRRLLDPGEAPVVPVYSGKVQSSLNLIPDNSSLLKLCPSEPEDEADLTDSGSPPSEDALPPGSPWKKKLRKKHEKEEKKMEEFPDQDISPLPQPSSRNKSRKHTEALQKLREVNKRLQDLRSCLSPKQHQSPALQNTDDEVVLVEGSVLPQNPRLFTLKIRCRADLVRLPVKTSEPLQNVVDHMASHLGVSPNRILLLFGETELSPTATPRTLKLGVADIIDCVVLASSSEDTETSQELRLRVQGKEKHQMLEISLSPDSPLKVLMSHYEEAMGLSGHKLSFFFDGTKLSGKELPTDLGLESGDLIEVWG

Nfatc2ip

NFATC2-interacting protein

412 amino acids

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.

45.121 kDa

MAEPLRGRGPRSRGGRGARRARGARGRCPRARQSPARLIPDTVLVDLVSDSDEEVLEVADPVEVPVARLPAPAKPEQDSDSDSEGAAEGPAGAPRTLVRRRRRRLLDPGEAPVVPVYSGKVQSSLNLIPDNSSLLKLCPSEPEDEADLTNSGSSPSEDDALPSGSPWRKKLRKKCEKEEKKMEEFPDQDISPLPQPSSRNKSRKHTEALQKLREVNKRLQDLRSCLSPKQHQSPALQSTDDEVVLVEGPVLPQSSRLFTLKIRCRADLVRLPVRMSEPLQNVVDHMANHLGVSPNRILLLFGESELSPTATPSTLKLGVADIIDCVVLASSSEATETSQELRLRVQGKEKHQMLEISLSPDSPLKVLMSHYEEAMGLSGHKLSFFFDGTKLSGKELPADLGLESGDLIEVWG

NFATC2IP

NFATC2-interacting protein

408 amino acids

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

44.581 kDa

MAEPVGKRGRLSRGSGAGRRPRAQRSPSRGTLDVVSVDLVSDSDEEIVEVTSARCAADEVEVAPSEPPGPVASRDDSDSDSEGADARPAGPPREPVRRRRRLVLDPGEAPLVPVYSGKVKSSLCLIPDDLSLLKLYPPGDEEEVELADSSGLYHEGSPSPGSPWKTKLRTKDKEEKKKTEILDLDNSPLSPPSPRTKSRKHTRALKKLSEVNKRLQDLRSCLSPEPPQGQEQQGQEDEVVLVEGPTLPETPRLFPLKIRCRADLVRLPLRMSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLASSPEATETSRQLQLRVQGKEKHQTLEVSLSRDSPLKTLMSHYEEAMGLSGRKLSFFFDGTKLSGRELPADLGMESGDLIEVWG