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NBL1

Gene
nbl1
Protein
Neuroblastoma suppressor of tumorigenicity 1
Organism
Danio rerio
Length
183 amino acids
Function
May act as a tumor suppressor.
Similarity
Belongs to the DAN family.
Mass
20.037 kDa
Sequence
MVMCVRAVLVCVLLELSRAAPHAHINRLALFPDKSAWCEAKNITQIVGHTGCTPRSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQTQWEVVTLDCSGSDEAPRVDKLVERILHCSCQSCSKESSQEGALLQLYPHEGAQDLPSLPDATHTHPQHAHMQADQRDADAHLDMHAPEAG

Gene
NBL1
Protein
Neuroblastoma suppressor of tumorigenicity 1
Organism
Homo sapiens
Length
181 amino acids
Function
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Similarity
Belongs to the DAN family.
Mass
19.408 kDa
Sequence
MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAED

Gene
Nbl1
Protein
Neuroblastoma suppressor of tumorigenicity 1
Organism
Mus musculus
Length
178 amino acids
Function
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Similarity
Belongs to the DAN family.
Mass
19.107 kDa
Sequence
MLWVLVGAVLPVMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKIVHCSCQACGKEPSHEGLNVYVQGEDSPGSQPGPHSHAHPHPGGQTPEPEEPPGAPQVEEEGAED

Gene
Nbl1
Protein
Neuroblastoma suppressor of tumorigenicity 1
Organism
Rattus norvegicus
Length
178 amino acids
Function
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Similarity
Belongs to the DAN family.
Mass
19.191 kDa
Sequence
MLWVLVGTVLPVMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKIVHCSCQACGKEPSHEGLNVYMQGEDGPGSQPGSHSHSHPHPGCQTPEPEEPPGAPQVEEEGAED

Gene
NBL1
Protein
Neuroblastoma suppressor of tumorigenicity 1
Organism
Gallus gallus
Length
177 amino acids
Function
May act as a tumor suppressor.
Similarity
Belongs to the DAN family.
Mass
19.495 kDa
Sequence
MLWFVVGALFPALLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCESKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLDCPGNDEIPRVDKLVEKILHCSCQACGKEPSHEGALFNVYLNAEENMPAEGPGPHHYAHHQQEVEEPPASSHHHHEEEGDE

Gene
nbl1
Protein
Neuroblastoma suppressor of tumorigenicity 1
Organism
Xenopus tropicalis
Length
176 amino acids
Function
May act as a tumor suppressor. Cytokine that has an axial patterning activity. Acts like bone morpho-genetic protein (BMP) antagonist in embryonic explants. Blocks the bmp2 activity (By similarity).
Similarity
Belongs to the DAN family.
Mass
19.449 kDa
Sequence
MTVWLLIGFLLPVAIFAAPPINRLALFPDKSAWCEAKNITQIVGHSGCESKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPIDSVWDVVTLECPGNEEFPRVDKLVEKILQCSCQACGKELSQEGAMFNVYLNTAEETLSPAETLGHHHHRPPAREEDSPAQSQREGESEE

Gene
nbl1
Protein
Neuroblastoma suppressor of tumorigenicity 1
Organism
Xenopus laevis
Length
175 amino acids
Function
May act as a tumor suppressor (By similarity). Cytokine that has an axial patterning activity. Acts like bone morpho-genetic protein (BMP) antagonist in embryonic explants. Blocks the bmp2 activity.
Similarity
Belongs to the DAN family.
Mass
19.338 kDa
Sequence
MTIWFLIGFLLPVAIFAAPPPINRLALFPDKSAWCEAKNITQIVGHSGCESKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPIDSVWDVVTLECPGNEEFPRVDKLVEKILQCSCQACGKELSQEGAMFNVYLNTAEDSPAESLGHHQHRPPAREDDSPAQSHREGESEE

Gene
NBL1
Protein
N-terminal-borealin-like protein
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
73 amino acids
Function
Component of the aurora kinase complex, also called chromosomal passenger complex (CPC), essential for chromosome segregation and metaphase chromosome alignment. Mediates the SLI15-BIR1 interaction within the CPC.
Similarity
Belongs to the borealin family.
Mass
8.547 kDa
Sequence
MIPALTPEERQKLRSAILHRMQLELETTEKLIENIKEETLKKLNLLQQPDATSAPQSKELIREVLEQEGRRIE