MYBL1

Myb-related protein A

757 amino acids

Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.

86.009 kDa

MAKRPRTSEEDDDFQYADHDYEISQQRSLKKICNRVKWTRDEDEKLKKLVEQNGTDDWAFIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEAEDRVIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGTKSSSERTGSSTLAQKPCVTMEHLHTQNQFYIPVQTHIPVYQYASPEDSCIEHASASANLVQQSFIDDDPDKEKKIKELELLLMSTENEIRRKRLSSQAGSLPGWSGSFVMEDCVPNTLNSLGEQTSEFYSMDETQGTSVQQNSPTKYLAVEANAVLSSLQTIPEFAETLELIESDPLAWSDVTSFDLSEAVASPVKPAPLKLMRIQHNERAAECQFNVSVMLDGKKHSSISGEEEAVFPTTPNLTKYSTPPAILRKKKRLRAGQSPVNELNDGLCNDAINVALKHTPVKTLPFSPSQFFNTCSGNEQFNLENPAFTSTPICGQKVLITTPLHKETTPTDQKENAGFRTPTIRRSLLGSTPRTPTPFKNALAAQEKKYGPLKLTSQPLAFLEEDIREVLKEETGTDIFLKEEDDSVYKSCKQEHNSSKKVRKSLVLDAWEKEELGAQLFTEDSGLDVQSENAYTTSLLMIPLLEIHDNRCNLPSENQDTNSSNKANAVIKKKLNACSSKNIKLEKSLQPNYEWEAVVYGKTEDQLIMTEQARRYLNAYTATSNTSRALIL

MYBL1

Myb-related protein A

752 amino acids

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).

85.887 kDa

MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKRIPSQPGSFSSWSGSFLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAETLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNTCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTPLKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISDMQSENRFTTSLLMIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL

Mybl1

Myb-related protein A

751 amino acids

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7813437, PubMed:23523368). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1 (PubMed:21750041, PubMed:23523368). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (PubMed:23523368).

85.728 kDa

MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHLQTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQNSPTKFLAVEANAVLSSLQTIPEFPRTLELIESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNSRNGGDSEAIPLTSPNVVKFSTPPTISRKKKRIRVGQSAGSELGSASLSEVGNRRIKHTPVKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLLTEDISDMQSENILTTSLLMIPLLEIHDNRCNLTPEKQDINSANKTYTLNKKRPNPNPCKAVKLEKSLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL

mybl1

Myb-related protein A

728 amino acids

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity.

83.577 kDa

MAGRARSEDEEEDGQFTEHDYDVSLQKGPKKPWSKLRWTKDEDDKVKKLVEKHGEDWGVVARHFINRSEVQCQHRWHKVLSPELVKGPWTKEEDQRVIELVHKYGPKKWSIIAKHLKGRIGKQCRERWHNHLNPDVKKSSWTEEEDRIIYSAHKRMGNRWAEIAKLLPGRTDNSIKNHWNSTMKRKVEQEGYLQDLMNCDRPSKLQAKSCAAPNHLQAQNQFYIPVQTQIPRYSSLSHDDNCIEIQNSFSFIQQPFVDADDPEKEKRIKELELLLMSAENEVRRKRVPSGSSLTWSESYHMGESMSNTMSHLEEQTHDFYSLDEIPNTSGQQSVEDKILAPEANIVLQPLETIPEFSETLELIDVDTVDWNNIESFELPFTASPAKHTPMKWIHEISPECALNSCLVQADGRGSASRVLSSSPAMPKFYSPPTILRKKKIHPDLSLTPEVRDASNVVLKGTPVKTRQYSPLQLFRSGNVQNHLNLDNLPLTSTPVCGQKISATPLQRQITPKKDKENAGFRTPTIRRSLMAVTPRTPTPFKNALAAQEKKYGPLRTVMQPLIFVEEDIMEVLKKETEKDVFIKEEKESDCKPMKQEHVSTVRKVRKSLILDSCDKEELGADFLAPDEVSQSQNGNTLPTSFLMIPLGERQDQKCDENTDTRKGSVMQRKNYIPATRNVKLQSSVQPLCEWEAVVYGKTEDQLIMTEQARRYLDTYKPTSSSGLRHLIL